Translational Research : the journal of laboratory and clinical medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease
In conclusion, the present findings suggested that upregulated MDM2 expression contributes to the degradation of Integrin β8 and activation of TGF-β1/TGFBR1/Smad3 signaling pathway, which ultimately leads to pericyte transition during DKD progression. These results indicate MDM2/Integrin β8 might be considered as therapeutic targets for DKD.PMID:37931653 | DOI:10.1016/j.trsl.2023.10.007 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - November 6, 2023 Category: Laboratory Medicine Authors: Yiling Cao Hua Su Jieyu Zeng Yaru Xie Zezhou Liu Feng Liu Yang Qiu Fan Yi Jihong Lin Hans-Peter Hammes Chun Zhang Source Type: research

TRPV4 in adipose tissue ameliorates diet-induced obesity by promoting white adipocyte browning
This study revealed the role of TRPV4 in adipose tissue in the development of obesity. Adipose-specific TRPV4 overexpression protected mice against diet-induced obesity (DIO) and promoted white fat browning. TRPV4 overexpression was also associated with decreased adipose inflammation and improved insulin sensitivity. Mechanistically, TRPV4 could directly promote white adipocyte browning via the AKT pathway. Consistently, adipose-specific TRPV4 knockout exacerbated DIO with impaired thermogenesis and activated inflammation. Corroborating our findings in mice, TRPV4 expression was low in the white adipose tissue of obese peo...
Source: Translational Research : the journal of laboratory and clinical medicine - November 5, 2023 Category: Laboratory Medicine Authors: Yan Zhang Jie Xue Wenjuan Zhu Haomin Wang Pengjiao Xi Derun Tian Source Type: research

Novel MSH2 and TSC2 variants in a Chinese family with Lynch syndrome and their synergistic impact in urothelial carcinoma
In this study, we present the case of a young patient diagnosed with upper urinary tract urothelial carcinoma, notable for a familial history of diverse malignancies. By employing genetic analysis, we verified the presence of Lynch syndrome within the family and detected novel variants, MSH2 p.A604D and TSC2 p.C738Y, utilizing NGS technology. Subsequently, we conducted validation experiments to assess the pathogenicity of the MSH2 and TSC2 variants. We illustrated that the MSH2 variant can result in diminished MSH2 expression, compromised mismatch repair function, and induce resistance to cisplatin in urothelial carcinoma....
Source: Translational Research : the journal of laboratory and clinical medicine - November 1, 2023 Category: Laboratory Medicine Authors: Mingyang Li Xingjian Yan He Liu Wenhao Miao Wenbo Wu Yuyang Zhao Chungang Wang Haitao Liu Source Type: research

ASH2L-mediated H3K4me3 drives diabetic nephropathy through HIPK2 and Notch1 pathway
Transl Res. 2023 Oct 23:S1931-5244(23)00160-3. doi: 10.1016/j.trsl.2023.10.002. Online ahead of print.ABSTRACTDiabetic nephropathy (DN) is one of the complications of diabetes. Long-term hyperglycemia in the kidney results in renal insufficiency, and eventually leads to end-stage renal disease. Epigenetic factor ASH2L has long been identified as a transcriptional activator, and we previously indicated that ASH2L aggravated fibrosis and inflammation in high glucose-induced glomerular mesangial cells, but the pathophysiological relevance and the mechanism of ASH2L-mediated H3K4me3 in DN is not well understood. Here we demons...
Source: Translational Research : the journal of laboratory and clinical medicine - October 25, 2023 Category: Laboratory Medicine Authors: Wen Zhong Chen Hong Yuyu Zhang Yuhui Li Chenxi Xiao Xinhua Liu Source Type: research

A diagnostic model based on DNA methylation haplotype block characteristics for identifying papillary thyroid carcinoma from thyroid adenoma
In this study, we aimed to develop and validate a diagnostic model for PTC based on DNA methylation markers. A total of 142 thyroid nodule tissue samples containing 84 cases of PTC and 58 cases of thyroid adenoma (TA) were collected for reduced representation bisulfite sequencing (RRBS) and subsequent analysis. The diagnostic model was constructed by the logistic regression (LR) method followed by 5-cross validation and based on 94 tissue methylation haplotype block (MHB) markers. The model achieved an area under the receiver operating characteristic curve (AUROC) of 0.974 (95% CI, 0.964-0.981) on 108 training samples and ...
Source: Translational Research : the journal of laboratory and clinical medicine - October 20, 2023 Category: Laboratory Medicine Authors: Dong Xu Yi Lai Hongmei Liu He Li Ningning Feng Yiying Liu Chengxiang Gong Yunzhi Zhang Jiaqing Zhou Yuling Shen Source Type: research