Translational Research : the journal of laboratory and clinical medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

RAS protein activator-like 2 (RASAL2) initiates peritubular capillary rarefaction in hypoxic renal interstitial fibrosis
Transl Res. 2024 Mar 5:S1931-5244(24)00047-1. doi: 10.1016/j.trsl.2024.03.003. Online ahead of print.ABSTRACTThe progression of chronic kidney disease (CKD) often involves renal interstitial fibrosis (RIF) and subsequent loss of peritubular capillaries (PTCs), which enhances disease severity. Despite advancements in our understanding of fibrosis, effective interventions for reversing capillary loss remain elusive. Notably, RIF exhibits reduced capillary density, whereas renal cell carcinoma (RCC) shows robust angiogenesis under hypoxic conditions. Using RNA sequencing and bioinformatics, we identified differentially expres...
Source: Translational Research : the journal of laboratory and clinical medicine - March 7, 2024 Category: Laboratory Medicine Authors: Yu Zhang Yiqiong Yang Xiuxiu Hu Bizhen Wei Qian Shen Chuanbing Shi Pingsheng Chen Source Type: research

Arginine methylation and respiratory disease
Transl Res. 2024 Mar 5:S1931-5244(24)00046-X. doi: 10.1016/j.trsl.2024.03.002. Online ahead of print.ABSTRACTArginine methylation, a vital post-translational modification, plays a pivotal role in numerous cellular functions such as signal transduction, DNA damage response and repair, regulation of gene transcription, mRNA splicing, and protein interactions. Central to this modification is the role of protein arginine methyltransferases (PRMTs), which have been increasingly recognized for their involvement in the pathogenesis of various respiratory diseases. This review begins with an exploration of the biochemical underpin...
Source: Translational Research : the journal of laboratory and clinical medicine - March 7, 2024 Category: Laboratory Medicine Authors: Binbin Zhang Youhong Guan Daxiong Zeng Ran Wang Source Type: research

Inhibition of G protein-coupled receptor 68 using homoharringtonine attenuates chronic kidney disease-associated cardiac impairment
Transl Res. 2024 Feb 22:S1931-5244(24)00032-X. doi: 10.1016/j.trsl.2024.02.004. Online ahead of print.ABSTRACTChronic kidney disease (CKD) induces cardiac inflammation and fibrosis and reduces survival. We previously demonstrated that G protein-coupled receptor 68 (GPR68) promotes cardiac inflammation and fibrosis in mice with 5/6 nephrectomy (5/6Nx) and patients with CKD. However, no method of GPR68 inhibition has been found that has potential for therapeutic application. Here, we report that Cephalotaxus harringtonia var. nana extract and homoharringtonine ameliorate cardiac inflammation and fibrosis under CKD by suppres...
Source: Translational Research : the journal of laboratory and clinical medicine - February 24, 2024 Category: Laboratory Medicine Authors: Yuya Yoshida Kohei Fukuoka Miyu Sakugawa Masayuki Kurogi Kengo Hamamura Keika Hamasaki Fumiaki Tsurusaki Kurumi Sotono Takumi Nishi Taiki Fukuda Taisei Kumamoto Kosuke Oyama Takashi Ogino Akito Tsuruta Kouta Mayanagi Tomohiro Yamashita Hiroyuki Fuchino No Source Type: research