Translational Research : the journal of laboratory and clinical medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Inhibition of OAT1/3 and CMPF uptake attenuates myocardial ischemia-induced chronic heart failure via decreasing fatty acid oxidation and the therapeutic effects of ruscogenin
Transl Res. 2023 Jun 12:S1931-5244(23)00103-2. doi: 10.1016/j.trsl.2023.06.001. Online ahead of print.ABSTRACTChronic heart failure (CHF) as a long-term disease is highly prevalent in elder people worldwide. Early diagnosis and treatments are crucial for preventing the development of CHF. Herein, we aimed to identify novel diagnostic biomarker, therapeutic target and drug for CHF. Untargeted metabolomic analysis has been used to characterize the different metabolomic profile between CHF patients and healthy people. Meanwhile, the targeted metabolomic study demonstrated the elevation of 3-carboxy-4-methyl-5-propyl-2-furanpr...
Source: Translational Research : the journal of laboratory and clinical medicine - June 14, 2023 Category: Laboratory Medicine Authors: Qiong Lai Xiaozhou Zhu Lu Zhang Junping Kou Fuming Liu Boyang Yu Fang Li Source Type: research

Polymerized human hemoglobin with low and high oxygen affinity in trauma models
Transl Res. 2023 Jun 1:S1931-5244(23)00091-9. doi: 10.1016/j.trsl.2023.05.006. Online ahead of print.ABSTRACTThe present study aimed to compare the ability of tense (T) and relaxed (R) quaternary state polymerized human hemoglobin (PolyhHb) to restore hemodynamics after severe trauma in a rat model, and to assess their relative toxicity in a guinea pigs (GPs). To assess the efficacy of these PolyhHbs in restoring hemodynamics, Wistar rats were subjected to traumatic brain injury (TBI) followed by hemorrhagic shock (HS). Animals were separated into 3 groups based on the resuscitation solution: Whole blood, T-state or R-stat...
Source: Translational Research : the journal of laboratory and clinical medicine - June 2, 2023 Category: Laboratory Medicine Authors: Cynthia R Muller Vasiliki Courelli Cynthia Walser Clayton T Cuddington Savannah R Wolfe Andre F Palmer Pedro Cabrales Source Type: research

Polymerized human hemoglobin with low and high oxygen affinity in trauma models
Transl Res. 2023 Jun 1:S1931-5244(23)00091-9. doi: 10.1016/j.trsl.2023.05.006. Online ahead of print.ABSTRACTThe present study aimed to compare the ability of tense (T) and relaxed (R) quaternary state polymerized human hemoglobin (PolyhHb) to restore hemodynamics after severe trauma in a rat model, and to assess their relative toxicity in a guinea pigs (GPs). To assess the efficacy of these PolyhHbs in restoring hemodynamics, Wistar rats were subjected to traumatic brain injury (TBI) followed by hemorrhagic shock (HS). Animals were separated into 3 groups based on the resuscitation solution: Whole blood, T-state or R-stat...
Source: Translational Research : the journal of laboratory and clinical medicine - June 2, 2023 Category: Laboratory Medicine Authors: Cynthia R Muller Vasiliki Courelli Cynthia Walser Clayton T Cuddington Savannah R Wolfe Andre F Palmer Pedro Cabrales Source Type: research

Polymerized human hemoglobin with low and high oxygen affinity in trauma models
Transl Res. 2023 Jun 1:S1931-5244(23)00091-9. doi: 10.1016/j.trsl.2023.05.006. Online ahead of print.ABSTRACTThe present study aimed to compare the ability of tense (T) and relaxed (R) quaternary state polymerized human hemoglobin (PolyhHb) to restore hemodynamics after severe trauma in a rat model, and to assess their relative toxicity in a guinea pigs (GPs). To assess the efficacy of these PolyhHbs in restoring hemodynamics, Wistar rats were subjected to traumatic brain injury (TBI) followed by hemorrhagic shock (HS). Animals were separated into 3 groups based on the resuscitation solution: Whole blood, T-state or R-stat...
Source: Translational Research : the journal of laboratory and clinical medicine - June 2, 2023 Category: Laboratory Medicine Authors: Cynthia R Muller Vasiliki Courelli Cynthia Walser Clayton T Cuddington Savannah R Wolfe Andre F Palmer Pedro Cabrales Source Type: research

Polymerized human hemoglobin with low and high oxygen affinity in trauma models
Transl Res. 2023 Jun 1:S1931-5244(23)00091-9. doi: 10.1016/j.trsl.2023.05.006. Online ahead of print.ABSTRACTThe present study aimed to compare the ability of tense (T) and relaxed (R) quaternary state polymerized human hemoglobin (PolyhHb) to restore hemodynamics after severe trauma in a rat model, and to assess their relative toxicity in a guinea pigs (GPs). To assess the efficacy of these PolyhHbs in restoring hemodynamics, Wistar rats were subjected to traumatic brain injury (TBI) followed by hemorrhagic shock (HS). Animals were separated into 3 groups based on the resuscitation solution: Whole blood, T-state or R-stat...
Source: Translational Research : the journal of laboratory and clinical medicine - June 2, 2023 Category: Laboratory Medicine Authors: Cynthia R Muller Vasiliki Courelli Cynthia Walser Clayton T Cuddington Savannah R Wolfe Andre F Palmer Pedro Cabrales Source Type: research