Translational Research : the journal of laboratory and clinical medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Metabolomic and lipidomic landscape of porcine kidney associated with kidney perfusion in heart beating donors and donors after cardiac death
Transl Res. 2023 Dec 3:S1931-5244(23)00202-5. doi: 10.1016/j.trsl.2023.12.001. Online ahead of print.ABSTRACTTransplant centers are currently facing a lack of tools to ensure adequate evaluation of the quality of the available organs, as well as a significant shortage of kidney donors. Therefore, efforts are being made to facilitate the effective use of available organs and expand the donor pool, particularly with expanded criteria donors. Fulfilling a need, we aim to present an innovative analytical method based on solid-phase microextraction (SPME) - chemical biopsy. In order to track changes affecting the organ througho...
Source: Translational Research : the journal of laboratory and clinical medicine - December 5, 2023 Category: Laboratory Medicine Authors: Iga Stryjak Natalia Warmuzi ńska Kamil Łuczykowski Karol Jaroch Peter Urbanellis Markus Selzner Barbara Bojko Source Type: research

Crosstalk between GABA < sub > A < /sub > receptors in astrocytes and neurons triggered by general anesthetic drugs
Transl Res. 2023 Nov 30:S1931-5244(23)00201-3. doi: 10.1016/j.trsl.2023.11.007. Online ahead of print.ABSTRACTGeneral anesthetic drugs cause cognitive deficits that persist after the drugs have been eliminated. Astrocytes may contribute to such cognition-impairing effects through the release of one or more paracrine factors that increase a tonic inhibitory conductance generated by extrasynaptic γ-aminobutyric acid type A (GABAA) receptors in hippocampal neurons. The mechanisms underlying this astrocyte-to-neuron crosstalk remain unknown. Interestingly, astrocytes express anesthetic-sensitive GABAA receptors. Here, we test...
Source: Translational Research : the journal of laboratory and clinical medicine - December 2, 2023 Category: Laboratory Medicine Authors: Dian-Shi Wang Li Ju Ars ène G Pinguelo Kirusanthy Kaneshwaran Sean C Haffey Irene Lecker Himaben Gohil Michael B Wheeler Lilia Kaustov Anthony Ariza MeiFeng Yu Allen Volchuk Benjamin E Steinberg Neil M Goldenberg Beverley A Orser Source Type: research

Efficacy of oral manganese and D-galactose therapy in a patient bearing a novel TMEM165 variant
This study offers exciting therapeutic perspectives for TMEM165-CDG.PMID:38013006 | DOI:10.1016/j.trsl.2023.11.005 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - November 28, 2023 Category: Laboratory Medicine Authors: Zo é Durin Alexandre Raynor Fran çois Fenaille Sophie Cholet Sandrine Vuillaumier-Barrot Jean-Meidi Alili Jo ël Poupon Nouzha Djebrani Oussedik Caroline Tuchmann-Durand Jennifer Attali Romain Touz é Thierry Dupr é Elodie Lebredonchel Marlyse Angah Ak Source Type: research

Metadherin orchestrates PKA and PKM2 to activate β-catenin signaling in podocytes during proteinuric chronic kidney disease
Transl Res. 2023 Nov 22:S1931-5244(23)00186-X. doi: 10.1016/j.trsl.2023.11.006. Online ahead of print.ABSTRACTPodocyte damage is the major cause of glomerular injury and proteinuria in multiple chronic kidney diseases. Metadherin (MTDH) is involved in podocyte apoptosis and promotes renal tubular injury in mouse models of diabetic nephropathy and renal fibrosis; however, its role in podocyte injury and proteinuria needs further exploration. Here, we show that MTDH was induced in the glomerular podocytes of patients with proteinuric chronic kidney disease and correlated with proteinuria. Podocyte-specific knockout of MTDH i...
Source: Translational Research : the journal of laboratory and clinical medicine - November 23, 2023 Category: Laboratory Medicine Authors: Xiaowen Chen Jing Xiao Danping Tao Yunyi Liang Sijia Chen Lingyu Shen Shuting Li Zerong Zheng Yao Zeng Congwei Luo Fenfen Peng Haibo Long Source Type: research