Translational Research : the journal of laboratory and clinical medicine 
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Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multiresolution characterization of cancer cell subgroups to identify pathways and cell states that are heterogen...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heteroge...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heteroge...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heteroge...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heteroge...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heteroge...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
β-catenin/CBP activation of mTORC1 signaling promotes partial epithelial-mesenchymal states in head and neck cancer
Transl Res. 2023 Jun 21:S1931-5244(23)00106-8. doi: 10.1016/j.trsl.2023.05.007. Online ahead of print.ABSTRACTHead and neck cancers, which include oral squamous cell carcinoma (OSCC) as a major subsite, exhibit cellular plasticity that includes features of an epithelial-mesenchymal transition (EMT), referred to as partial-EMT (p-EMT). To identify molecular mechanisms contributing to OSCC plasticity, we performed a multiphase analysis of single cell RNA sequencing (scRNAseq) data from human OSCC. This included a multi-resolution characterization of cancer cell subgroups to identify pathways and cell states that are heteroge...
Source: Translational Research : the journal of laboratory and clinical medicine - June 23, 2023 Category: Laboratory Medicine Authors: Eric R Reed Stacy A Jankowski Anthony J Spinella Vikki Noonan Robert Haddad Kenichi Nomoto Junji Matsui Manish V Bais Xaralabos Varelas Maria A Kukuruzinska Stefano Monti Source Type: research
Topical delivery of MEK inhibitor binimetinib prevents the development of cutaneous neurofibromas in Neurofibromatosis type 1 mutant mice
Transl Res. 2023 Jun 16:S1931-5244(23)00105-6. doi: 10.1016/j.trsl.2023.06.003. Online ahead of print.ABSTRACTCutaneous neurofibromas (cNFs) are a hallmark of patients with the neurofibromatosis type 1 (NF1) genetic disorder. These benign nerve sheath tumors, which can amount to thousands, develop from puberty onward, often cause pain and are considered by patients to be the primary burden of the disease. Mutations of NF1, encoding a negative regulator of the RAS signaling pathway, in the Schwann cell (SCs) lineage are considered to be at the origin of cNFs. The mechanisms governing cNFs development are poorly understood, ...
Source: Translational Research : the journal of laboratory and clinical medicine - June 18, 2023 Category: Laboratory Medicine Authors: F Coulpier P Pulh L Oubrou J Naudet L Fertitta J-M Gregoire A Bocquet A-M Schmitt P Wolkenstein K J Radomska P Topilko Source Type: research
Topical delivery of MEK inhibitor binimetinib prevents the development of cutaneous neurofibromas in Neurofibromatosis type 1 mutant mice
Transl Res. 2023 Jun 16:S1931-5244(23)00105-6. doi: 10.1016/j.trsl.2023.06.003. Online ahead of print.ABSTRACTCutaneous neurofibromas (cNFs) are a hallmark of patients with the neurofibromatosis type 1 (NF1) genetic disorder. These benign nerve sheath tumors, which can amount to thousands, develop from puberty onward, often cause pain and are considered by patients to be the primary burden of the disease. Mutations of NF1, encoding a negative regulator of the RAS signaling pathway, in the Schwann cell (SCs) lineage are considered to be at the origin of cNFs. The mechanisms governing cNFs development are poorly understood, ...
Source: Translational Research : the journal of laboratory and clinical medicine - June 18, 2023 Category: Laboratory Medicine Authors: F Coulpier P Pulh L Oubrou J Naudet L Fertitta J-M Gregoire A Bocquet A-M Schmitt P Wolkenstein K J Radomska P Topilko Source Type: research
Topical delivery of MEK inhibitor binimetinib prevents the development of cutaneous neurofibromas in Neurofibromatosis type 1 mutant mice
Transl Res. 2023 Jun 16:S1931-5244(23)00105-6. doi: 10.1016/j.trsl.2023.06.003. Online ahead of print.ABSTRACTCutaneous neurofibromas (cNFs) are a hallmark of patients with the neurofibromatosis type 1 (NF1) genetic disorder. These benign nerve sheath tumors, which can amount to thousands, develop from puberty onward, often cause pain and are considered by patients to be the primary burden of the disease. Mutations of NF1, encoding a negative regulator of the RAS signaling pathway, in the Schwann cell (SCs) lineage are considered to be at the origin of cNFs. The mechanisms governing cNFs development are poorly understood, ...
Source: Translational Research : the journal of laboratory and clinical medicine - June 18, 2023 Category: Laboratory Medicine Authors: F Coulpier P Pulh L Oubrou J Naudet L Fertitta J-M Gregoire A Bocquet A-M Schmitt P Wolkenstein K J Radomska P Topilko Source Type: research
Topical delivery of MEK inhibitor binimetinib prevents the development of cutaneous neurofibromas in Neurofibromatosis type 1 mutant mice
Transl Res. 2023 Jun 16:S1931-5244(23)00105-6. doi: 10.1016/j.trsl.2023.06.003. Online ahead of print.ABSTRACTCutaneous neurofibromas (cNFs) are a hallmark of patients with the neurofibromatosis type 1 (NF1) genetic disorder. These benign nerve sheath tumors, which can amount to thousands, develop from puberty onward, often cause pain and are considered by patients to be the primary burden of the disease. Mutations of NF1, encoding a negative regulator of the RAS signaling pathway, in the Schwann cell (SCs) lineage are considered to be at the origin of cNFs. The mechanisms governing cNFs development are poorly understood, ...
Source: Translational Research : the journal of laboratory and clinical medicine - June 18, 2023 Category: Laboratory Medicine Authors: F Coulpier P Pulh L Oubrou J Naudet L Fertitta J-M Gregoire A Bocquet A-M Schmitt P Wolkenstein K J Radomska P Topilko Source Type: research
Topical delivery of MEK inhibitor binimetinib prevents the development of cutaneous neurofibromas in Neurofibromatosis type 1 mutant mice
Transl Res. 2023 Jun 16:S1931-5244(23)00105-6. doi: 10.1016/j.trsl.2023.06.003. Online ahead of print.ABSTRACTCutaneous neurofibromas (cNFs) are a hallmark of patients with the neurofibromatosis type 1 (NF1) genetic disorder. These benign nerve sheath tumors, which can amount to thousands, develop from puberty onward, often cause pain and are considered by patients to be the primary burden of the disease. Mutations of NF1, encoding a negative regulator of the RAS signaling pathway, in the Schwann cell (SCs) lineage are considered to be at the origin of cNFs. The mechanisms governing cNFs development are poorly understood, ...
Source: Translational Research : the journal of laboratory and clinical medicine - June 18, 2023 Category: Laboratory Medicine Authors: F Coulpier P Pulh L Oubrou J Naudet L Fertitta J-M Gregoire A Bocquet A-M Schmitt P Wolkenstein K J Radomska P Topilko Source Type: research
Biotherapy of experimental acute kidney injury: emerging novel therapeutic strategies
This article summarizes the latest progress in AKI biotherapy, focusing on potential clinical targets and novel treatment strategies that merit further investigation in future pre-clinical and clinical studies.PMID:37329950 | DOI:10.1016/j.trsl.2023.06.002 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - June 17, 2023 Category: Laboratory Medicine Authors: Ning Li Lu Han Xinyue Wang Ou Qiao Li Zhang Yanhua Gong Source Type: research
Inhibition of OAT1/3 and CMPF uptake attenuates myocardial ischemia-induced chronic heart failure via decreasing fatty acid oxidation and the therapeutic effects of ruscogenin
Transl Res. 2023 Jun 12:S1931-5244(23)00103-2. doi: 10.1016/j.trsl.2023.06.001. Online ahead of print.ABSTRACTChronic heart failure (CHF) as a long-term disease is highly prevalent in elder people worldwide. Early diagnosis and treatments are crucial for preventing the development of CHF. Herein, we aimed to identify novel diagnostic biomarker, therapeutic target and drug for CHF. Untargeted metabolomic analysis has been used to characterize the different metabolomic profile between CHF patients and healthy people. Meanwhile, the targeted metabolomic study demonstrated the elevation of 3-carboxy-4-methyl-5-propyl-2-furanpr...
Source: Translational Research : the journal of laboratory and clinical medicine - June 14, 2023 Category: Laboratory Medicine Authors: Qiong Lai Xiaozhou Zhu Lu Zhang Junping Kou Fuming Liu Boyang Yu Fang Li Source Type: research
Inhibition of OAT1/3 and CMPF uptake attenuates myocardial ischemia-induced chronic heart failure via decreasing fatty acid oxidation and the therapeutic effects of ruscogenin
Transl Res. 2023 Jun 12:S1931-5244(23)00103-2. doi: 10.1016/j.trsl.2023.06.001. Online ahead of print.ABSTRACTChronic heart failure (CHF) as a long-term disease is highly prevalent in elder people worldwide. Early diagnosis and treatments are crucial for preventing the development of CHF. Herein, we aimed to identify novel diagnostic biomarker, therapeutic target and drug for CHF. Untargeted metabolomic analysis has been used to characterize the different metabolomic profile between CHF patients and healthy people. Meanwhile, the targeted metabolomic study demonstrated the elevation of 3-carboxy-4-methyl-5-propyl-2-furanpr...
Source: Translational Research : the journal of laboratory and clinical medicine - June 14, 2023 Category: Laboratory Medicine Authors: Qiong Lai Xiaozhou Zhu Lu Zhang Junping Kou Fuming Liu Boyang Yu Fang Li Source Type: research
