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Dual-regulation by Cx32 in hepatocyte to trigger and worsen liver graft injury
CONCLUSIONS: Our findings propose Cx32 as a dual mechanistic factor for oxidative stress and inflammatory signaling pathways in regulating cell apoptosis on liver graft injury, which suggests a promising therapeutic targets for liver graft injury.PMID:37507007 | DOI:10.1016/j.trsl.2023.07.008 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - July 28, 2023 Category: Laboratory Medicine Authors: Fei Huang Zhizhao Deng Qian Zhang Zheng Zhang Xianlong Li Weiqi Zeng Yanling Wang Ziqing Hei Dongdong Yuan Source Type: research

Plasma protein signatures reflect systemic immunity and allograft function in kidney transplantation
Transl Res. 2023 Jul 26:S1931-5244(23)00125-1. doi: 10.1016/j.trsl.2023.07.007. Online ahead of print.NO ABSTRACTPMID:37507006 | DOI:10.1016/j.trsl.2023.07.007 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - July 28, 2023 Category: Laboratory Medicine Authors: Konrad Buscher Rebecca Rixen Paula Sch ütz Birte H üchtmann Veerle van Marck Barbara Heitplatz Ulrich Jehn Daniela A Braun Gert Gabriels Hermann Pavenst ädt Stefan Reuter Source Type: research

Synthetic surfactant with a combined SP-B and SP-C analogue is efficient in rabbit models of adult and neonatal respiratory distress syndrome
Transl Res. 2023 Jul 25:S1931-5244(23)00127-5. doi: 10.1016/j.trsl.2023.07.009. Online ahead of print.ABSTRACTRespiratory distress syndrome (RDS) in premature infants is caused by insufficient amounts of endogenous lung surfactant and is efficiently treated with replacement therapy using animal-derived surfactant preparations. On the other hand, adult/acute RDS (ARDS) occurs secondary to e.g., sepsis, aspiration of gastric contents, and multitrauma and is caused by alveolar endothelial damage, leakage of plasma components into the airspaces and inhibition of surfactant activity. Instillation of surfactant preparations in A...
Source: Translational Research : the journal of laboratory and clinical medicine - July 27, 2023 Category: Laboratory Medicine Authors: Pavol Mikolka Nina Kronqvist Marie Haegerstrand-Bj örkman Kristaps Jaudzems Petra Kosutova Maros Kolomaznik Mihkel Saluri Michael Landreh Andrea Calkovska Tore Curstedt Jan Johansson Source Type: research

Noninvasive early differential diagnosis and progression monitoring of ovarian cancer using the copy number alterations of plasma cell-free DNA
In conclusion, our study demonstrated the clinical utility of CNV profiling in plasma cfDNA using LC-WGS as a cost-effective and accessible liquid biopsy for OV.PMID:37499745 | DOI:10.1016/j.trsl.2023.07.005 (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - July 27, 2023 Category: Laboratory Medicine Authors: Lu Chen Rong Ma Chang Luo Qin Xie Xin Ning Kaidi Sun Fanling Meng Meng Zhou Jie Sun Source Type: research

Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease
This study aimed to explore the molecular mechanism of lipid metabolic regulation in kidney, especially renal PTECs, and elucidate the role of lipid metabolic related molecule lipin-1 in diabetic lipid-related kidney damage. In this study, lipin-1-deficient db/db mouse model and STZ/HFD-induced T2DM mouse model were used to determine the effect of lipin-1 on DKD development. Then RPTCs and LPIN1 knockdown or overexpressed HK-2 cells induced by PA were used to investigate the mechanism. We found that the expression of lipin-1 increased early and then decreased in kidney during the progression of DKD. Glucose and lipid metab...
Source: Translational Research : the journal of laboratory and clinical medicine - July 11, 2023 Category: Laboratory Medicine Authors: Simei Lin Liang Wang Yingli Jia Ying Sun Panshuang Qiao Yazhu Quan Jihan Liu Huihui Hu Baoxue Yang Hong Zhou Source Type: research