Mitochondrial aspartate/glutamate carrier AGC1 regulates cardiac function via Drp1-mediated mitochondrial fission in doxorubicin-induced cardiomyopathy

CONCLUSIONS: In summary, our data illustrate that AGC1, as a novel contributor to DCM, regulates cardiac function via Drp1-mediated mitochondrial fission, indicating that targeting AGC1-Drp1 axis could be a potential therapeutic strategy for DOX-induced cardiomyopathy.PMID:37402419 | DOI:10.1016/j.trsl.2023.06.004

Source: Translational Research : the journal of laboratory and clinical medicine - July 4, 2023 Category: Laboratory Medicine Authors: Yan Xia Jiayu Jin Ao Chen Danbo Lu Xinyu Che Jiaqi Ma Su Li Ming Yin Zheng Yang Hao Lu Chenguang Li Jinxiang Chen Muyin Liu Yuan Wu Hui Gong Yunzeng Zou Zhangwei Chen Juying Qian Junbo Ge Source Type: research