Artificial Intelligence Assisted Repurposing of Lubiprostone Alleviates Tubulointerstitial Fibrosis

In conclusion, the high throughput Proximal tubule-on-chip system shows improved in vivo-like function and indicates the potential utility for renal fibrosis drug screening. Additionally, repurposed Lubiprostone shows an effective potency to treat TIF via inhibiting 3 major profibrotic signaling pathways such as TGFβ/Smad, JAK/STAT, and epithelial-mesenchymal transition (EMT) and restores kidney function.PMID:37541485 | DOI:10.1016/j.trsl.2023.07.010
Source: Translational Research : the journal of laboratory and clinical medicine - Category: Laboratory Medicine Authors: Source Type: research