Plasma protein signatures reflect systemic immunity and allograft function in kidney transplantation
Transl Res. 2023 Jul 26:S1931-5244(23)00125-1. doi: 10.1016/j.trsl.2023.07.007. Online ahead of print.ABSTRACTKidney transplantation causes large perturbations of the immune system. While many studies focus on the allograft, insights into systemic effects are largely missing. Here, we analyzed the systemic immune response in 3 cohorts of kidney transplanted patients. Using serum proteomics, laboratory values, mass cytometry, histological and clinical parameters, inter-patient heterogeneity was leveraged for multi-omic co-variation analysis. We identified circulating immune modules (CIM) that describe extra-renal signatures of co-regulated plasma proteins. CIM are present in nontransplanted controls, in transplant conditions and during rejection. They are enriched in pathways linked to kidney function, extracellular matrix, signaling, and cellular activation. A complex leukocyte response in the blood during allograft quiescence and rejection is associated with CIM activity and CIM-specific cytokines. CIM activity correlates with kidney function including a 2-month prediction. Together, the data suggest a systemic and multi-layered response of transplant immunity that might be insightful for understanding allograft dysfunction and developing translational biomarkers.PMID:37507006 | DOI:10.1016/j.trsl.2023.07.007
Source: Translational Research : the journal of laboratory and clinical medicine - Category: Laboratory Medicine Authors: Konrad Buscher Rebecca Rixen Paula Sch ütz Birte H üchtmann Veerle Vanmarck Barbara Heitplatz Ulrich Jehn Daniela A Braun Gert Gabriels Hermann Pavenst ädt Stefan Reuter Source Type: research
More News: Bone Graft | Kidney Transplant | Kidney Transplantation | Laboratory Medicine | Study | Transplant Surgery | Transplants | Urology & Nephrology