< b > < i > Costaria costata < /i > < /b > Extract Suppresses Development of Atopic Dermatitis in chloro-2,4-dinitrobenzene-treated NC/Nga Mice
We investigated the potential effects of Costaria costata (CC) on atopic dermatitis (AD) development in chloro-2,4-dinitrobenzene (DNCB)-treated NC/Nga mice. CC is a brown alga distributed across the seas of Korea, China, and Japan. A total of 40 mice were randomly assigned to 5 groups with 8 mice per group: untreated Balb/c mice, AD control (0.1% w/v DNCB-treated NC/Nga mice), positive control (i.e., DNCB-treated NC/Nga mice fed a dietary supplement of 66.6 mg/kg of body weight [b.w.] of CJLP133), DNCB-treated NC/Nga mice fed a dietary supplement of 100 mg/kg b.w. of CCE10 (CCE10 100), and DNCB-treated mice fed a dietary ...
Source: Skin Pharmacology and Physiology - May 29, 2018 Category: Dermatology Source Type: research
Hybrid Diffuse Reflectance Spectroscopy: Non-Erythemal in vivo Testing of Sun Protection Factor
Conclusion: Due to the elimination of any erythemal relevant UVB and UVA doses, absolutely no skin reaction occurs. Consequently there is no need to define a MED any more. For the first time an alternative way to SPF is shown without any ethical concerns of SPF testing in vivo and/or any restriction of SPF testing in vitro. Regardless of the type of formulation or the level of protection, an excellent correlation of SPFHDRS and SPF24444 for sunscreen labeling could be found. By this new alternative non-erythemal technique, not only SPF values can be measured, but also UVA-PF values can be calculated with an excellent corre...
Source: Skin Pharmacology and Physiology - May 29, 2018 Category: Dermatology Source Type: research
Solvent-Extracted Wool Wax: Thermotropic Properties and Skin Efficacy
Conclusions: The suitability of the solvent-extracted wool wax for application in the preparation of cosmetics and dermatological products was demonstrated.Skin Pharmacol Physiol 2018;31:198 –205 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - May 9, 2018 Category: Dermatology Source Type: research
The Influence of Reactive Oxygen Species and Glucocorticoids on Dry Skin in a Mouse Model of Arthritis
Conclusion: This study suggested that inhibiting ROS and glucocorticoids is important to ameliorate dry skin in arthritis, which may provide a novel treatment option for dry skin in RA patients.Skin Pharmacol Physiol 2018;31:188 –197 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - April 26, 2018 Category: Dermatology Source Type: research
Rituximab in Refractory Chronic Spontaneous Urticaria: An Encouraging Therapeutic Approach
Conclusion: Rituximab is a chimeric murine/human monoclonal antibody directed against CD20, which depletes memory B-lymphocytes that are necessary for autoantibody production. The abrogation of the autoantibody production is the proposed mechanism by which it may alleviate the symptoms of CSU.Skin Pharmacol Physiol 2018;31:184 –187 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - April 12, 2018 Category: Dermatology Source Type: research
Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches
Conclusion: The HO-DMNs are efficient, safe, and convenient for wide use in cosmetic applications for skin barrier restoration and moisturization.Skin Pharmacol Physiol 2018;31:163 –171 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - April 5, 2018 Category: Dermatology Source Type: research
Topical Treatment of Skin Injury Inflicted in Mice by X-Ray Irradiation
Conclusion: Skin anti-inflammatory treatment was the most effective but must be applied for several months. Further preclinical studies should be conducted, assimilating a human cancer radiation therapeutic schema with the aim of optimizing skin inflammation treatment.Skin Pharmacol Physiol 2018;31:175 –183 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - April 4, 2018 Category: Dermatology Source Type: research
Commentary on the “Evidence- and Consensus-Based (S3) Guidelines for the Treatment of Actinic Keratosis” Published by the International League of Dermatological Societies in Cooperation with the European Dermatology Forum
In 2015, the International League of Dermatological Societies and the European Dermatology Forum published a guideline for the treatment of actinic keratosis, which is classified as an evidence- and consensus-based S3 guideline. From the point of view of the GD Task Force “Licht.Hautkrebs.Prävention,” an interdisciplinary expert panel of the Society for Dermopharmacy for the prevention and treatment of skin cancer, this guideline reveals strengths and weaknesses but, in summary, does not meet the claim for an evidence- and consensus-based S3 guideline.Skin Pharmacol Physiol 2018;31:144 –146 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - April 3, 2018 Category: Dermatology Source Type: research
Effect of Fluid Intake on Hydration Status and Skin Barrier Characteristics in Geriatric Patients: An Explorative Study
Conclusions: Approximately half of the patients were diagnosed as being dehydrated according to osmolality, which is the current reference standard. However, there was no association with fluid intake, questioning the clinical relevance of this measure. Results indicate that single skin barrier parameters are poor markers for fluid intake or osmolality. Epidermal hydration might play a role but most probably in combination with other tests.Skin Pharmacol Physiol 2018;31:155 –162 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - April 3, 2018 Category: Dermatology Source Type: research
Dermocosmetics for Use in Rosacea: Guideline of the Society for Dermopharmacy
Rosacea is a widespread inflammatory skin disease that is chronically recurrent and affects predominately the central parts of the face. Affected individuals typically react to numerous cosmetics with redness, burning, and/or worsening of the complexion. Consequently, there is a high demand for dermocosmetics that do not provoke such reactions and are suitable for use in rosacea. The present guideline of the Society for Dermopharmacy describes the requirements that dermocosmetics for use in rosacea should meet. They include, inter alia, methods to prove the efficacy of and tolerance to these cosmetics, as well as the produ...
Source: Skin Pharmacology and Physiology - March 29, 2018 Category: Dermatology Source Type: research
Punicalagin and ( –)-Epigallocatechin-3-Gallate Rescue Cell Viability and Attenuate Inflammatory Responses of Human Epidermal Keratinocytes Exposed to Airborne Particulate Matter PM10
Conclusions: This study demonstrates that polyphenolic antioxidants, such as punicalagin and ( –)-EGCG, rescue keratinocyte viability and attenuate the inflammatory responses of these cells due to airborne particles.Skin Pharmacol Physiol 2018;31:134 –143 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 23, 2018 Category: Dermatology Source Type: research
Effects of Short-Term Moisturizer Application in Different Ethnic Skin Types: Noninvasive Assessment with Optical Coherence Tomography and Reflectance Confocal Microscopy
Conclusion: Different ethnic skin types showed variations in skin morphology and treatment response to short-term moisturizer application. OCT and RCM were useful methods for noninvasive, real-time, repeated assessment of ethnic skin.Skin Pharmacol Physiol 2018;31:125 –133 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 14, 2018 Category: Dermatology Source Type: research
Physiological and Molecular Effects of in vivo and ex vivo Mild Skin Barrier Disruption
The success of topically applied treatments on skin relies on the efficacy of skin penetration. In order to increase particle or product penetration, mild skin barrier disruption methods can be used. We previously described cyanoacrylate skin surface stripping as an efficient method to open hair follicles, enhance particle penetration, and activate Langerhans cells. We conducted ex vivo and in vivo measurements on human skin to characterize the biological effect and quantify barrier disruption-related inflammation on a molecular level. Despite the known immunostimulatory effects, this barrier disruption and hair follicle o...
Source: Skin Pharmacology and Physiology - March 6, 2018 Category: Dermatology Source Type: research
Sesquiterpene-Enriched Extract of < b > < i > Curcuma aeruginosa < /i > < /b > Roxb. Retards Axillary Hair Growth: A Randomised, Placebo-Controlled, Double-Blind Study
Conclusion: CA-ext in lotion is an efficacious inhibitor of axillary hair growth, the preparation was well accepted and matched the effectiveness of finasteride. Thus, with some refinement, it should provide an alternative pharmacological treatment for unwanted androgenic hair.Skin Pharmacol Physiol 2018;31:99 –106 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 9, 2018 Category: Dermatology Source Type: research
A Time-Series Study of the Effect of Air Pollution on Outpatient Visits for Acne Vulgaris in Beijing
Conclusion: This study provides indirect evidence for a link between acne vulgaris and air pollution.Skin Pharmacol Physiol 2018;31:107-113 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 6, 2018 Category: Dermatology Source Type: research
