Antioxidant Properties of Ferulic Acid and Its Possible Application
Ferulic acid has low toxicity and possesses many physiological functions (anti-inflammatory, antioxidant, antimicrobial activity, anticancer, and antidiabetic effect). It has been widely used in the pharmaceutical, food, and cosmetics industry. Ferulic acid is a free radical scavenger, but also an inhibitor of enzymes that catalyze free radical generation and an enhancer of scavenger enzyme activity. Ferulic acid has a protective role for the main skin structures: keratinocytes, fibroblasts, collagen, elastin. It inhibits melanogenesis, enhances angiogenesis, and accelerates wound healing. It is widely applied in skin care...
Source: Skin Pharmacology and Physiology - September 20, 2018 Category: Dermatology Source Type: research
Tretinoin Loaded Nanoemulsion for Acne Vulgaris: Fabrication, Physicochemical and Clinical Efficacy Assessments
Conclusion: We successfully developed stable nanoparticles. It was a stable oil-in-water emulsion with particle size of about 150 nm, and containing circular and separated particles. In a pilot clinical study, the number of acne lesions as well as the size and intensity of porphyrin production significantly reduced after topical application of NE-TRE. This formula shows proper efficiency and good loading capacity of TRE in the drug delivery system.Skin Pharmacol Physiol 2018;31:316 –323 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - September 10, 2018 Category: Dermatology Source Type: research
Novel Facial Cream Containing Carnosine Inhibits Formation of Advanced Glycation End-Products in Human Skin
Conclusion: Topically applied carnosine protects against the glycation induced by MG. Novel FC-CARN significantly reduced levels of AGEs in both epidermis and reticular dermis in human skin explants.Skin Pharmacol Physiol 2018;31:324 –331 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - September 10, 2018 Category: Dermatology Source Type: research
Influence of Relative Humidity on Electrodermal Levels and Responses
Conclusion: This suggests that ambient humidity influences the recording of EDA levels and is important to consider when these parameters are used, but is not important in the recording or analysis of EDA responses.Skin Pharmacol Physiol 2018;31:298 –307 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - September 7, 2018 Category: Dermatology Source Type: research
Application of Photoacoustic Methods and Confocal Microscopy for Monitoring of Therapeutic Response in Plaque Psoriasis
In this study, photoacoustic imaging and confocal laser scanning microscopic (CLSM) methods were investigated for their suitability in psoriasis follow-up examinations. Using a high-resolution photoacoustic system, the vascular structures of 11 psoriatic patients and 6 healthy volunteers were investigated. No differences were detected with respect to the average vessel diameter and vasculature per unit volume in the tissue of healthy volunteers and non-lesional and lesional skin areas of psoriatic patients. By means of CLSM, the diameters of the dermal papillae of 6 volunteers and 6 psoriatic patients were determined. The ...
Source: Skin Pharmacology and Physiology - September 7, 2018 Category: Dermatology Source Type: research
Age- and Diabetes-Related Changes in the Free Fatty Acid Composition of the Human Stratum Corneum
Of particular importance for Stratum corneum (SC) lipids are the free fatty acids (FFAs). Age-related changes of the SC structure lead to diminished capacity for barrier compensation. The aims of this cross-sectional study were to identify even-numbered especially odd-numbered FFAs within the intercorneocytic lamellar lipid structures of the SC and to explore age- and diabetes-related changes in FFAs. Gas chromatography – flame ionisation detection was used to qualitatively and quantitatively assess FFAs extracted from the SC. 110 subjects aged over 60 years (elderly/healthy), 110 subjects aged 18–40 (young/healthy) an...
Source: Skin Pharmacology and Physiology - August 21, 2018 Category: Dermatology Source Type: research
Antidermatophytic Activity and Skin Retention of Clotrimazole Microemulsion and Microemulsion-Based Gel in Comparison to Conventional Cream
Conclusion: Results revealed the capacity of ME and MBG in improving skin bioavailability of CTZ while reducing the risk of systemic side effects. Thereby, ME and MBG could increase the efficacy of CTZ for dermatophytosis treatment in comparison to conventional cream.Skin Pharmacol Physiol 2018;31:292 –297 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - August 21, 2018 Category: Dermatology Source Type: research
Epidermal Lamellar Granules
In the mid-1950s and 1960s, transmission electron microscopes became widely available, leading to many studies of the ultrastructure of various tissues including the epidermis. Most of these studies involved tissue fixation with formaldehyde and postfixation with osmium tetroxide. A few studies employed freeze-fracture electron microscopy. One set of these studies identified a small organelle variously called lamellar granules (LGs), lamellar bodies, membrane-coating granules, cementsomes, and Odland bodies. LGs are round to ovoid in shape, with a diameter of about 200 nm. They have a bounding membrane surrounding a stack ...
Source: Skin Pharmacology and Physiology - August 15, 2018 Category: Dermatology Source Type: research
A Pilot Study to Evaluate the Effects of Topically Applied Cosmetic Creams on Epidermal Responses
The objective of this study was to evaluate the changes in epidermal properties and inflammatory mediators after 4 days of topical application of 2 different polymers formulated in cosmetic creams. Ten healthy volunteers (mean age ± SD: 20.0 ± 2.4 years) completed the study. TEWL, color, and pH were not significantly different after repeated application of these polymers. Hydration was significantly lower at sites treated with polymer A after 5 days. Significant increases in IL-1α, IL-1RA, and IL-1β were observed after cr eam application at sites treated with polymer A. This is the first study to apply noninvasive meas...
Source: Skin Pharmacology and Physiology - August 15, 2018 Category: Dermatology Source Type: research
Controversy on the Use of Povidone-Iodine in Chronic Wounds
Skin Pharmacol Physiol 2018;31:261 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - August 8, 2018 Category: Dermatology Source Type: research
Follicular Penetration of Caffeine from Topically Applied Nanoemulsion Formulations Containing Penetration Enhancers: In vitro Human Skin Studies
Conclusions: This study demonstrated effective delivery of caffeine as a hydrophilic model drug into and through hair follicles and showed that follicles and surrounding regions may be targeted by optimised formulations for specific treatments.Skin Pharmacol Physiol 2018;31:252 –260 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - July 12, 2018 Category: Dermatology Source Type: research
Inflammation: A Contributor to Depressive Comorbidity in Inflammatory Skin Disease
The prevalence of affective disorders such as depression and anxiety is particularly high in patients with autoimmune diseases, including inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa. A dysregulated immune response has been linked to the precipitation of depression in many patient populations. However, studies examining the extent to which the underlying skin disease inflammatory processes contribute to depression and a subsequent decline in quality of life are limited. The published literature over the past 5 years was reviewed for evidence of a relationship between depress...
Source: Skin Pharmacology and Physiology - June 28, 2018 Category: Dermatology Source Type: research
Differentiation of Different Nonmelanoma Skin Cancer Types Using OCT
Conclusion: This study showed that it is possible to distinguish between the different nonmelanoma skin cancers by using OCT, but further prospective studies have to be conducted to validate the sensitivity and specificity of the criteria.Skin Pharmacol Physiol 2018;31:238 –245 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - June 12, 2018 Category: Dermatology Source Type: research
Basic Fibroblast Growth Factor Influences Epidermal Homeostasis of Living Skin Equivalents through Affecting Fibroblast Phenotypes and Functions
Conclusions: bFGF, through affecting the phenotypes and functions of fibroblasts, especially KGF expression, influenced epidermal homeostasis in an LSE model.Skin Pharmacol Physiol 2018;31:229 –237 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - May 30, 2018 Category: Dermatology Source Type: research
Diclofenac Sodium 3% in Hyaluronic Acid 2.5% Gel Significantly Diminishes the Actinic Keratosis Area and Severity Index
Conclusions: AKASI is an easy-to-use quantitative tool for assessing the treatment outcome of field-directed therapies. Field-directed therapies of AK should no longer be monitored by assessments based on lesion counts alone.Skin Pharmacol Physiol 2018;31:206 –211 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - May 29, 2018 Category: Dermatology Source Type: research
