Curcumin-Loaded Self-Microemulsifying Gel for Enhancing Wound Closure
Conclusions: This is the first study that utilized self-microemulsifying gel loaded with curcumin as a delivery system for wound healing. However, the effect of this delivery system on wound healing or skin disease treatment should be further investigated.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 20, 2021 Category: Dermatology Source Type: research
Capsaicin: Plants of the Genus < b > < i > Capsicum < /i > < /b > and Positive Effect of Oriental Spice on Skin Health
Background: Capsaicin, the main pungent ingredient in hot chili peppers, causes excitation of small sensory neurons. It also provides the basic pungent flavor inCapsicum fruits.Summary: Capsaicin plays a vital role as an agonist for the TRPV1 (transient receptor potential cation channel, subfamily V, member 1) receptor. TRPV1 is essential for the reduction of oxidative stress, pain sensations, and inflammation. Therefore, it has many pros related to health issue. Activation and positive impact of TRPV1 via capsaicin has been studied in various dermatological conditions and in other skin-related issues. Past studies documen...
Source: Skin Pharmacology and Physiology - January 5, 2021 Category: Dermatology Source Type: research
Association between Vaspin rs2236242 Gene Polymorphism and Psoriasis Vulgaris
Conclusion: Our study demonstrated that vaspin rs2236242 polymorphism is related to psoriasis in the Turkish population. Polymorphisms of the vaspin gene might serve as diagnostic biomarkers of psoriasis.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - December 18, 2020 Category: Dermatology Source Type: research
HIF-1 α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth
Conclusion: Here we demonstrate a significantly enhanced proliferative activity for both established substances against AGA (minoxidil and caffeine) and the HIF-1 α-stimulating agent DFP in a 3D DPC spheroid culture model with equal results for DFP and minoxidil. These favorable characteristics make such compounds potential water-soluble alternatives to minoxidil.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - December 16, 2020 Category: Dermatology Source Type: research
Investigation of ex vivo Skin Penetration of Coenzyme Q10 from Microemulsions and Hydrophilic Cream
Conclusions: The HPLC method quantified the trace quantities of the CoQ10 distributed across the various skin layers and, hence, can be used to investigate the skin penetration of CoQ10 from various dermal standard and nano-formulations.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - November 19, 2020 Category: Dermatology Source Type: research
Flare Size but Not Intensity Reflects Histamine-Induced Itch
Conclusion: In histamine-induced skin inflammation, itch and increased blood flow are linked. Thus, the area of histamine-induced flare may be used as a surrogate marker for histamine-induced itch.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 26, 2020 Category: Dermatology Source Type: research
Prospective Nanotechnology-Based Strategies for Enhanced Intra- and Transdermal Delivery of Antifungal Drugs
Topical therapy of superficial fungal infections allows the prevention of systemic side effects and provides drug targeting at the site of disease. However, an appropriate drug concentration in these sites should be provided to ensure the efficacy of such local treatment. The enhancement of intra- and transdermal penetration and accumulation of antifungal drugs is an important aspect here. The present overview is focused on novel nano-based formulations served to improve antimycotic penetration through the skin. Furthermore, it summarizes various approaches towards the stimulation of drug penetration through and into the s...
Source: Skin Pharmacology and Physiology - October 22, 2020 Category: Dermatology Source Type: research
Importance of microRNAs in Skin Oncogenesis and Their Suitability as Agents and Targets for Topical Therapy
Skin cancer is the most common cancer worldwide, with rapidly increasing incidence and consistent mortality. Skin cancer encompasses melanoma and non-melanoma skin cancer, which in turn is mainly divided into cutaneous squamous cell carcinoma and basal cell carcinoma. Small noncoding micro RNAs (miRNAs) regulate protein expression after transcription and play a role in the development and progression of skin cancer. Deregulated expression of miRNAs in skin cancer is associated with cell proliferation, angiogenesis, metastasis, apoptosis, immune response, and drug resistance. Specifi c patterns of miRNAs in specific skin ...
Source: Skin Pharmacology and Physiology - October 20, 2020 Category: Dermatology Source Type: research
Lycopene and Melatonin: Antioxidant Compounds in Cosmetic Formulations
Background: The use of antioxidants has become a common practice in the development of antiaging cosmetics.Objective: The aim of this study was to evaluate the clinical efficacy of cosmetic formulations containing lycopene and melatonin antioxidants.Method: Thirty-six healthy women from 32 to 65 years were enrolled in this study. The study was carried out for 10 weeks, 2 preconditioning weeks with a control cream without antioxidants, and 8-week test with creams containing antioxidants in study. A multifunctional skin physiology monitor (Courage amp; Khazaka electronic GmbH ®, Germany) was used to measure skin sebum conte...
Source: Skin Pharmacology and Physiology - October 16, 2020 Category: Dermatology Source Type: research
Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods
The dermal papilla comprises mesenchymal cells in hair follicles, which play the main role in regulating hair growth. Maintaining the potential hair inductivity of dermal papilla cells (DPCs) and dermal sheath cells during cell culture is the main factor in in vitro morphogenesis and regeneration of hair follicles. Using common methods for the cultivation of human dermal papilla reduces the maintenance requirements of the inductive capacity of the dermal papilla and the expression of specific dermal papilla biomarkers. Optimizing culture conditions is therefore crucial for DPCs. Moreover, exosomes appear to play a key role...
Source: Skin Pharmacology and Physiology - October 14, 2020 Category: Dermatology Source Type: research
Does Hyaluronidase Enhance Drug Penetration to Mechanoreceptors?
Conclusions: In the in vitro sinus hair preparation, the addition of hyaluronidase does not allow easier access to slowly adapting mechanoreceptors within the follicle.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 14, 2020 Category: Dermatology Source Type: research
Publisher's Note
Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - September 18, 2020 Category: Dermatology Source Type: research
Erratum
Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - September 11, 2020 Category: Dermatology Source Type: research
