New Hydrogels Enriched with Antioxidants from Saffron Crocus Can Find Applications in Wound Treatment and/or Beautification
Saffron extracts have a long history of application as skin protectant, possibly due to their ability to scavenge free radicals. In this work, the performance of a hydrogel enriched with antioxidant compounds isolated from saffron crocus (Crocus sativus L.) petals was tested. These hydrogels could be considered as new drug delivery system. Hydrogels are crosslinked polymer networks that absorb large quantities of water but retain the properties of a solid, thus making ideal dressings for sensitive skin. We tested antioxidant-enriched hydrogels on primary mouse fibroblasts. Hydrogels enriched with kaempferol and crocin extr...
Source: Skin Pharmacology and Physiology - January 31, 2018 Category: Dermatology Source Type: research
Laser Scanning Microscopic Investigations of the Decontamination of Soot Nanoparticles from the Skin
Conclusion: The application of barrier-enhancing formulations in combination with a cleanser may reduce the penetration of harmful airborne particulates by preventing their adhesion to the skin and facilitating their removal by subsequent washing with the cleanser.Skin Pharmacol Physiol 2018;31:87-94 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 19, 2018 Category: Dermatology Source Type: research
Vitamin D and the Pathophysiology of Inflammatory Skin Diseases
Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.Skin Pharmacol Physiol 2018;31:74-86 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 5, 2018 Category: Dermatology Source Type: research
Acknowledgement to the Reviewers
Skin Pharmacol Physiol 2017;30:329-330 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 3, 2018 Category: Dermatology Source Type: research
Contents Vol. 30, 2017
Skin Pharmacol Physiol 2017;30:II-V (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 3, 2018 Category: Dermatology Source Type: research
Neoplastic Multifocal Skin Lesions: Biology, Etiology, and Targeted Therapies for Nonmelanoma Skin Cancers
Neoplastic skin lesions are multifocal, diffuse skin infiltrations of particular relevance in the differential diagnosis of ulcerative, nodular, or crusting skin lesions. Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and also actinic keratosis (AK), are the most common malignant tumors in humans. BCCs do not proliferate rapidly and most of the times do not metastasize, while SCCs are more infiltrative, metastatic, and destructive. AKs are precursor lesions of cutaneous SCCs. The classical therapy of NMSCs makes use of photodynamic therapy associated with chemotherapeut...
Source: Skin Pharmacology and Physiology - December 20, 2017 Category: Dermatology Source Type: research
Consensus on Wound Antisepsis: Update 2018
Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. In addition, systemic antibiotic therapy is required in case the infection spreads. If applied preventively, the Wounds-at-Risk Score allows an assessment of the risk for infection and thus appropriateness of the indication. The content of this updated consensus recommendation still largely co...
Source: Skin Pharmacology and Physiology - December 20, 2017 Category: Dermatology Source Type: research
Editorial
Skin Pharmacol Physiol 2017;30:I (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - December 8, 2017 Category: Dermatology Source Type: research
Capsaicin Used on Skin Influences Ion Transport Pathways: An in vitro Study
Acute, adverse skin effects to capsaicin can be activated by inhibition of sodium transport not only in nociceptive neurons, but also in keratinocytes. The aim of the current study was to describe and compare immediate (15 s) and prolonged (30 min) effects of capsaicin on epidermal (not neural) sodium transport using a rabbit skin model. Skin fragments (n = 169) were incubated in 4 conditions: undisturbed ion transport (U;n = 48); inhibited sodium transport (INa;n = 34) with amiloride used as sodium transport blocker; long-term irritation by capsaicin with undisturbed ion transport (CAPSA-U;n = 43) and with inhibited sodiu...
Source: Skin Pharmacology and Physiology - November 7, 2017 Category: Dermatology Source Type: research
Pleiotropic Effects of White Willow Bark and 1,2-Decanediol on Human Adult Keratinocytes
Conclusions: These results suggest that both natural compounds were able to differently affect several functions of LPS-stressed keratinocytes suggesting their potential role for the prevention of acne vulgaris, without adverse effects.Skin Pharmacol Physiol 2018;31:10-18 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - November 7, 2017 Category: Dermatology Source Type: research
Development and Evaluation of Lipid Nanoparticles Containing Natural Botanical Oil for Sun Protection: Characterization and in vitro and in vivo Human Skin Permeation and Toxicity
In this study, we developed stable solid lipid nanoparticles (SLNs) containing the chemical UV filter octyl methoxycinnamate (OMC). In parallel, we produced similar stable SLNs in which 20% of the OMC content was replaced by the botanical urucum oil. When these SLNs were applied to the skin of human volunteers, no changes in fluorescence lifetimes or redox ratios of the endogenous skin fluorophores were seen, suggesting that the formulations did not induce toxic responses in the skin. Ex vivo (skin diffusion) tests showed no significant penetration. In vitro studies showed that when 20% of the OMC was replaced by urucum oi...
Source: Skin Pharmacology and Physiology - November 3, 2017 Category: Dermatology Source Type: research
The Prevalence of Periodontitis Is Increased in Psoriasis and Linked to Its Inverse Subtype
Periodontitis and psoriasis are suggested to be co-occurring, chronic inflammatory conditions with overlapping characteristics. However, respective evidence is rare and data on risk factors of periodontitis in psoriasis patients are minimal. The aim of this study was to expand the evidence of psoriasis-associated periodontitis and establish a potential risk profile for periodontitis. In total, data from 209 exacerbated psoriasis patients were retrospectively analyzed on recordings of periodontitis and compared with those of 91 patients with chronic spontaneous urticaria (CSU). Analysis showed a significantly increased prev...
Source: Skin Pharmacology and Physiology - November 1, 2017 Category: Dermatology Source Type: research
Histamine Iontophoresis as in vivo Model to Study Human Skin Inflammation with Minimal Barrier Impairment: Pilot Study Results of Application of the Model to a Sensitive Skin Panel
Conclusion: Histamine iontophoresis is a well-standardized in vivo model to quantitatively study the early stages of cutaneous inflammation with minimal impact on the skin barrier. In line with previous studies, it highlighted increased sensory perceptions in SS.Skin Pharmacol Physiol 2017;30:246-259 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 25, 2017 Category: Dermatology Source Type: research
Comparison of the Skin Penetration of 3 Metabolically Stable Chemicals Using Fresh and Frozen Human Skin
Conclusion: The penetration of the 3 chemicals was essentially unaffected by freezing the skin at -20 °C for up to 12 weeks.Skin Pharmacol Physiol 2017;30:234-245 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 25, 2017 Category: Dermatology Source Type: research
Impact of Body Site, Age, and Gender on the Collagen/Elastin Index by Noninvasive in vivo Vertical Two-Photon Microscopy
Background/Aims: Extrinsic and intrinsic skin aging is subject to constant remodeling and degradation processes, primarily in components of the extracellular matrix. While collagen fibers thin out during the aging process, the amorphous elastin fibers accumulate. These are essential formative components of the dermis. So far, these processes have been detected in vertical histological sections of invasive biopsies and recently in noninvasive horizontal scans.Methods: In this pilot study, a modified noninvasive 2-photon microscope was applied to measure the collagen/elastin index of skin in vivo. The obtained images permit ...
Source: Skin Pharmacology and Physiology - October 25, 2017 Category: Dermatology Source Type: research
