Potential Applications of Phyto-Derived Ceramides in Improving Epidermal Barrier Function
The outer most layer of the skin, the stratum corneum, consists of corneocytes which are coated by a cornified envelope and embedded in a lipid matrix of ordered lamellar structure. It is responsible for the skin barrier function. Ceramides (CERs) are the backbone of the intercellular lipid membranes. Skin diseases such as atopic dermatitis and psoriasis and aged skin are characterized by dysfunctional skin barrier and dryness which are associated with reduced levels of CERs. Previously, the effectiveness of supplementation of synthetic and animal-based CERs in replenishing the depleted natural skin CERs and restoring the ...
Source: Skin Pharmacology and Physiology - April 13, 2017 Category: Dermatology Source Type: research
Histoproteomic Characterization of Localized Cutaneous Amyloidosis in X-Linked Reticulate Pigmentary Disorder
Skin Pharmacol Physiol 2017;30:90-93 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - April 3, 2017 Category: Dermatology Source Type: research
Radical-Scavenging Activity of a Sunscreen Enriched by Antioxidants Providing Protection in the Whole Solar Spectral Range
Conclusion: A sunscreen containing AO improved the photoprotection in the VIS and NIR ranges. The sunscreen was retained in the stratum corneum. Therefore, these results show the possibility of the development of effective and safer sunscreen products.Skin Pharmacol Physiol 2017;30:81-89 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 20, 2017 Category: Dermatology Source Type: research
Phototoxicity of Doxycycline: A Systematic Review on Clinical Manifestations, Frequency, Cofactors, and Prevention
Conclusion: Evidence base must be improved for giving advice on appropriate prevention measures to travelers taking doxycycline and having a risk of significant sun exposure.Skin Pharmacol Physiol 2017;30:76-80 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 14, 2017 Category: Dermatology Source Type: research
Stingless Bee Honey, the Natural Wound Healer: A Review
Conclusion: The application of honey to the wound has been widely used since ancient times. As a result, it is essential to understand the pharmacological mechanism of the honey towards the physiology of the wounded skin in order to optimize the healing rate in the future.Skin Pharmacol Physiol 2017;30:66-75 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 14, 2017 Category: Dermatology Source Type: research
Standardization of an in vitro Model for Evaluating the Bioavailability of Topically Applied Compounds on Damaged Skin: Application to Sunscreen Analysis
Conclusion: This standardized in vitro methodology using pig or human skin for damaged skin will add valuable information for the safety assessment of topically applied products.Skin Pharmacol Physiol 2017;30:55-65 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 9, 2017 Category: Dermatology Source Type: research
Clinical Evidence of Increase in Hair Growth and Decrease in Hair Loss without Adverse Reactions Promoted by the Commercial Lotion ECOHAIR ®
Conclusion: This study provides scientific support for the clinical use of ECOHAIR ® as a treatment to be used in noncicatricial alopecia.Skin Pharmacol Physiol 2017;30:46-54 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 22, 2017 Category: Dermatology Source Type: research
Post-Finasteride Adverse Effects in Male Androgenic Alopecia: A Case Report of Vitiligo
Finasteride has proved to be relatively safe and effective in the therapeutic management of male androgenic alopecia. However, literature data report several endocrine imbalances inducing various adverse effects, which often persist after treatment cessation in the form of post-finasteride syndrome. Here we present the case of a 52-year-old man receiving finasteride (1 mg/day) who developed an uncommon adverse effect represented by generalized vitiligo 2 months after finasteride discontinuation. Associated adverse effects encountered were represented by mild sexual dysfunction (as determined by the International Index of E...
Source: Skin Pharmacology and Physiology - February 21, 2017 Category: Dermatology Source Type: research
Efficacy of Glucosamine Sulphate in Skin Ageing: Results from an ex vivo Anti-Ageing Model and a Clinical Trial
Conclusion:Both experiments showed that GS has a positive effect on epidermal and dermal markers associated with age.Skin Pharmacol Physiol 2017;30:36-41 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 17, 2017 Category: Dermatology Source Type: research
Acknowledgement to the Reviewers
Skin Pharmacol Physiol 2016;29:332-333 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 8, 2017 Category: Dermatology Source Type: research
Contents Vol. 29, 2016
Skin Pharmacol Physiol 2016;29:I-IV (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 8, 2017 Category: Dermatology Source Type: research
The Preventive Effect of Coffee Compounds on Dermatitis and Epidermal Pigmentation after Ultraviolet Irradiation in Mice
Conclusion: It is suggested that the oral administration of CA prevented dermatitis and pigmentation after UVB irradiation in mice.Skin Pharmacol Physiol 2017;30:24-35 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 2, 2017 Category: Dermatology Source Type: research
Nrf2- and Bach1 May Play a Role in the Modulation of Ultraviolet A-Induced Oxidative Stress by Acetyl-11-Keto- β-Boswellic Acid in Skin Keratinocytes
Conclusions: AKBA protects skin cells from UVA-induced damage by modulating inflammatory mediators and/or ROS production. Therefore, AKBA has potential in the development of skin care products.Skin Pharmacol Physiol 2017;30:13-23 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 31, 2017 Category: Dermatology Source Type: research
Sensitive Skin: Assessment of the Skin Barrier Using Confocal Raman Microspectroscopy
Conclusion: The skin barrier in SS is not impaired in terms of SC thickness, water, NMF, and ceramides/fatty acid content. The failure of biophysical techniques to follow alterations in the molecular composition of the skin barrier revealed by CRS emphasizes a strong need in sensitive and specific tools for in vivo skin barrier analysis.Skin Pharmacol Physiol 2017;30:1-12 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 25, 2017 Category: Dermatology Source Type: research
Low-Molecular-Weight Hydrophilic and Lipophilic Antioxidants in Nonmelanoma Skin Carcinomas and Adjacent Normal-Looking Skin
Low-molecular-weight antioxidants are some of the most efficient agents of the skin defense mechanism against environmental factors, such as cosmic rays, smoke, and pollutants. The total skin concentrations of hydrophilic ascorbic and uric acids, as well as lipophilic α-tocopherol, β-carotene, and ubiquinol-10 antioxidants were determined by an HPLC-EC detector from 18 biopsies of human nonmelanoma skin carcinomas and 18 biopsies from skin areas adjacent to carcinomas. No significant differences in the concentrations of lipophilic antioxidants in both carcinoma s and normal-looking skin areas adjacent to carcinomas were ...
Source: Skin Pharmacology and Physiology - January 18, 2017 Category: Dermatology Source Type: research
