A composite of hepatocyte growth factor and 5 α-dihydrotestosterone–gelatin microspheres with adipose-derived stem cells enhances wound healing
Conclusions: This study confirms the efficacy of ADSCs treated with amnion and HGF– and 5α-DHT–gelatin microspheres in accelerating wound healing and effectively restoring sebaceous glands . This engineered tissue provides insight into and a novel therapeutic material for burns and full-thickness skin wounds.¬¬ (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - April 19, 2022 Category: Dermatology Source Type: research
Induction of Radiodermatitis in Nude Mouse Model using Gamma Irradiator IBL 637
Conclusion: This study describes for the first time a protocol to induce a moderate radiodermatitis in the nude mouse model SKH1-Hrhr using a IBL 637 gamma irradiator. This protocol will allow researchers to s tudy novel treatment strategies to alleviate the burden of a radiodermatitis as a side effect of cancer treatment. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - April 13, 2022 Category: Dermatology Source Type: research
Correlation of Body Mass Index with Epidermal Biophysical Properties Varies with Gender in Chinese
Conclusion: These results demonstrate that correlations of BMI with age and epidermal functions vary with gender. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - April 4, 2022 Category: Dermatology Source Type: research
Percutaneous egression: What do we know?
Background: The process by which drugs leave the bloodstream to enter the skin compartments is important in determining appropriate routes of delivery and developing more efficacious medications. We conducted a general literature review on percutaneous egression mechanisms.
Summary: Studies demonstrate that the stratum corneum (SC) is a compartment for systemically delivered drugs. Upon reviewing the available literature, it became apparent that there may be multiple mechanisms of percutaneous egression dependent upon drug physiochemical properties. These mechanisms include, but are not limited to, desquamation, sebum se...
Source: Skin Pharmacology and Physiology - March 24, 2022 Category: Dermatology Source Type: research
LncRNA XIST engages in psoriasis via sponging miR-338-5p to regulate keratinocyte proliferation and inflammation
(Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 1, 2022 Category: Dermatology Source Type: research
Lateral Dermal Penetration is Dependent on the Lipophilicity of Active Ingredients
Conclusion:
The vertical and lateral penetration movement of caffeine was found to exceed that of LIP1 through the hydrophilic dermal environment. The findings of this study show that the lipophilicity of active ingredients influence the penetration movement and that skin enables a conical increasing lateral diffusivity and transdermal delivery. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 16, 2022 Category: Dermatology Source Type: research
RP-18 TLC and Computational Descriptors of Skin Permeability of Sunscreens
Abstract
The relationships between the reversed-phase thin layer chromatographic retention parameters obtained on octadecyl-modified silica (RP-18) sorbent for mobile phases containing water and one of six water-miscible organic modifiers (acetone, methanol, acetonitrile, tetrahydrofurane, N,N-dimethylformamide, 1,4-dioxane) and skin permeability coefficients were studied for a group of 21 cosmetic raw materials, mainly organic sunscreens and preservatives.
The correlations between the skin permeability coefficients log Kd calculated in silico using EpiSuite software and the RP-18 thin layer chromatographic retention par...
Source: Skin Pharmacology and Physiology - February 7, 2022 Category: Dermatology Source Type: research
Erratum
Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 7, 2022 Category: Dermatology Source Type: research
Common cosmetic compounds can reduce air pollution-induced oxidative stress and pro-inflammatory response in the skin
Conclusion: AP leads to a significant skin damage which can be effectiv ely prevented by using some conventional cosmetic and dermatological ingredients with various mechanisms of action. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 31, 2022 Category: Dermatology Source Type: research
An exploratory study of the effects of the pH of synthetic urine on skin integrity in healthy participants
Conclusions: This study revealed that urine disrupts healthy skin integrity; however, its effects are not pH dependent. Transient changes were observed on the acid mantle of the skin due to its innate buffering capacity. Future studies need to examine the effects of urine combined with bac teria responsible for pH elevation in patients with urinary incontinence. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 28, 2022 Category: Dermatology Source Type: research
Association of Sensitive Eyes with Sensitive Skin: A Worldwide Study of 10,743 Subjects
Conclusion: This large study shows that self-declared sensitive eyes are very frequent and commonly associated with sensitive skin. Triggering factors of sensitive eyes are more specific. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 19, 2022 Category: Dermatology Source Type: research
Association of sensitive eyes with sensitive skin:
A worldwide study of 10,743 subjects
Conclusion: This large study shows that self-declared “sensitive eyes” ar e very frequent and commonly associated with sensitive skin. Triggering factors of sensitive eyes are more specific. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 19, 2022 Category: Dermatology Source Type: research
Current Views on Noninvasive in vivo Determination of Physiological Parameters of the Stratum Corneum Using Confocal Raman Microspectroscopy
Confocal Raman microspectroscopy is widely used in dermatology and cosmetology for analysis of the concentration of skin components (lipids, natural moisturizing factor molecules, water) and the penetration depth of cosmetic/medical formulations in the human stratum corneum (SC) in vivo. In recent years, it was shown that confocal Raman microspectroscopy can also be used for noninvasive in vivo depth-dependent determination of the physiological parameters of the SC, such as lamellar and lateral organization of intercellular lipids (ICLs), folding properties of keratin, water mobility, and hydrogen bonding states. The resul...
Source: Skin Pharmacology and Physiology - January 10, 2022 Category: Dermatology Source Type: research
Current views on non-invasive in vivo determination of physiological parameters of the stratum corneum using confocal Raman microspectroscopy
Confocal Raman microspectroscopy is widely used in dermatology and cosmetology for analysis of the concentration of skin components (lipids, natural moisturizing factor molecules, water) and the penetration depth of cosmetic/medical formulations in the human stratum corneum (SC) in vivo. In recent years, it was shown that confocal Raman microspectroscopy can also be used for non-invasive in vivo depth-dependent determination of the physiological parameters of the SC, such as lamellar and lateral organization of intercellular lipids, folding properties of keratin, water mobility and hydrogen bonding states. The results show...
Source: Skin Pharmacology and Physiology - January 10, 2022 Category: Dermatology Source Type: research
Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled In Vitro
Introduction: Although it has been reported that the anti-diabetic drug metformin has multiple extra-hypoglycemic activities, such as anti-oxidation, anti-aging and even anti-tumor, topical metformin also can induce hair regeneration, but the precise mechanism involved in that process is still unclear. Objectives: To assess the effect of metformin on hair growth in a mouse hair follicle reconstitution model generated by in vitro self-assembled three-dimensional aggregates of epidermal and dermal cells (3D aggregates). Methods: Epidermal cells and dermal cells were isolated and cultured from the mouse skin of fifty C57BL/6 ...
Source: Skin Pharmacology and Physiology - December 9, 2021 Category: Dermatology Source Type: research
