Topical Treatment of Infantile Haemangiomas: A Comparative Study on the Selection of a Semi-Solid Vehicle
Conclusion: The 1% w/w PR-Cl cream resulted the most suitable formulation for improving drug permeation through the human epidermis. On the contrary, the negligible permeation profile through full-thickness skin pointed out that PR-Cl cannot diffuse significantly to reach the deeper layers of human skin.Skin Pharmacol Physiol 2016;29:210-219 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - August 18, 2016 Category: Dermatology Source Type: research
Acceleration of Collagen Breakdown by Extracellular Basic pH in Human Dermal Fibroblasts
Conclusion: < /i > < /b > Our results indicate that skin pH is an important effector of collagen formation in wound healing. This finding will aid in the development of new pH-targeted therapeutic strategies. < br / > Skin Pharmacol Physiol 2016;29:204-209 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - July 21, 2016 Category: Dermatology Source Type: research
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Collagen and elastin networks make up the majority of the extracellular matrix in many organs, such as the skin. The mechanisms which are involved in the maintenance of homeostatic equilibrium of these networks are numerous, involving the regulation of genetic expression, growth factor secretion, signalling pathways, secondary messaging systems, and ion channel activity. However, many factors are capable of disrupting these pathways, which leads to an imbalance of homeostatic equilibrium. Ultimately, this leads to changes in the physical nature of skin, both functionally and cosmetically. Although various factors have been...
Source: Skin Pharmacology and Physiology - July 19, 2016 Category: Dermatology Source Type: research
Intrinsic versus Extrinsic Aging: A Histopathological, Morphometric and Immunohistochemical Study of Estrogen Receptor β and Androgen Receptor
In conclusion, both ERβ and AR decline gradually with intrinsic and extrinsic aging. This decline is more obvious with extrinsic aging. Further large-scaled studies are recommended to expand, validate and translate current findings to clinically significant, diagnostic and therapeutic applications. Molecular studies to investigate the probable ligand-independent action of both receptors are warranted. In addition, their gene expression patterns and associated signaling and metabolic pathways can also be tackled to provide a basis for further interventions in pathological processes that involve their dysregulation.Skin Pha...
Source: Skin Pharmacology and Physiology - July 11, 2016 Category: Dermatology Source Type: research
Reducing the Harmful Effects of Infrared Radiation on the Skin Using Bicosomes Incorporating β-Carotene
Conclusions: The formation of FRs by IR radiation does not depend on the increase of skin temperature. The decrease of FRs and the preservation of collagen fibers in the skin treated with Bcb indicate the potential of this lipid system to protect skin under IR exposure.Skin Pharmacol Physiol 2016;29:169-177 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - July 5, 2016 Category: Dermatology Source Type: research
