Sea Buckthorn (Hippopha ë rhamnoides L.) Oil Improves Atopic Dermatitis-Like Skin Lesions via Inhibition of NF- & #x03BA;B and STAT1 Activation
Conclusion: These results suggest that SBT oil had a beneficial effect on AD-like skin lesions, partially via inhibition of the Th2 chemokines TARC and MDC in inflamed skin.Skin Pharmacol Physiol 2017;30:268-276 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 25, 2017 Category: Dermatology Source Type: research
Accelerating Topical Anaesthesia Using Microneedles
Conclusion: Pre-treatment of skin with microneedles significantly enhances the permeation of tetracaine. Microneedles have the potential to more than halve the onset time for anaesthesia when applying Ametop gel.Skin Pharmacol Physiol 2017;30:277-283 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 25, 2017 Category: Dermatology Source Type: research
Determination of the Influence of the Antiphlogistic Ingredients Panthenol and Bisabolol on the SPF Value in vivo
Background: Today, the sun protection factor (SPF) value of sunscreen products is determined in vivo with a standardized protocol (EN ISO 24444:2010), and the measured SPF biological end point is the visible skin erythema. However, many of the sunscreen products currently available on the market have antiphlogistic ingredients, which may potentially result in an overestimated SPF of the sunscreen.Aims: To investigate the potential influence of the antiphlogistic ingredients panthenol and bisabolol in sunscreens on the determined SPF value in vivo.Methods: Formulations with different concentrations of the antiphlogistic ing...
Source: Skin Pharmacology and Physiology - October 25, 2017 Category: Dermatology Source Type: research
Impact of a pH 5 Oil-in-Water Emulsion on Skin Surface pH
Conclusions: The tested pH 5 O/W emulsion seems to improve regeneration and stabilization of pHss.Skin Pharmacol Physiol 2017;30:292-297 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 25, 2017 Category: Dermatology Source Type: research
Response of the Endothelium to the Epicutaneous Application of Leukotriene B4
Conclusion: The early phase of inflammation is characterized by EC proliferation and HIF-1 α expression. Vascular expansion continues over time. CP and VD are seen in both phases of inflammation. Angiogenesis, vascular network formation, and perfusion are time-dependent processes which are mutually related during inflammation.Skin Pharmacol Physiol 2017;30:306-314 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 25, 2017 Category: Dermatology Source Type: research
An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia
Conclusion: A caffeine-based topical liquid should be considered as not inferior to minoxidil 5% solution in men with androgenetic alopecia.Skin Pharmacol Physiol 2017;30:298-305 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 25, 2017 Category: Dermatology Source Type: research
Expression Profiles of Long Noncoding RNA in UVA-Induced Human Skin Fibroblasts
Conclusions: lncRNA profiles were aberrantly expressed in UVA-HDF and might play a key role in skin photoaging. This study provides novel insights into the repeated UVA-damaging pathology and potential targets for treatment of human skin photoaging.Skin Pharmacol Physiol 2017;30:315-323 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 25, 2017 Category: Dermatology Source Type: research
An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% versus Minoxidil 5% Solution in Male Androgenetic Alopecia
Conclusion: A caffeine-based topical liquid should be considered as not inferior to minoxidil 5% solution in men with androgenetic alopecia.Skin Pharmacol Physiol 2017;30:298-305 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 20, 2017 Category: Dermatology Source Type: research
Response of the Endothelium to the Epicutaneous Application of Leukotriene B4
Conclusion: The early phase of inflammation is characterized by EC proliferation and HIF-1 α expression. Vascular expansion continues over time. CP and VD are seen in both phases of inflammation. Angiogenesis, vascular network formation, and perfusion are time-dependent processes which are mutually related during inflammation.Skin Pharmacol Physiol 2017;30:306-314 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 19, 2017 Category: Dermatology Source Type: research
Determination of the Influence of the Antiphlogistic Ingredients Panthenol and Bisabolol on the SPF Value in vivo
Background: Today, the sun protection factor (SPF) value of sunscreen products is determined in vivo with a standardized protocol (EN ISO 24444:2010), and the measured SPF biological end point is the visible skin erythema. However, many of the sunscreen products currently available on the market have antiphlogistic ingredients, which may potentially result in an overestimated SPF of the sunscreen.Aims: To investigate the potential influence of the antiphlogistic ingredients panthenol and bisabolol in sunscreens on the determined SPF value in vivo.Methods: Formulations with different concentrations of the antiphlogistic ing...
Source: Skin Pharmacology and Physiology - October 3, 2017 Category: Dermatology Source Type: research
Impact of a pH 5 Oil-in-Water Emulsion on Skin Surface pH
Conclusions: The tested pH 5 O/W emulsion seems to improve regeneration and stabilization of pHss.Skin Pharmacol Physiol 2017;30:292-297 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - October 3, 2017 Category: Dermatology Source Type: research
Accelerating Topical Anaesthesia Using Microneedles
Conclusion: Pre-treatment of skin with microneedles significantly enhances the permeation of tetracaine. Microneedles have the potential to more than halve the onset time for anaesthesia when applying Ametop gel.Skin Pharmacol Physiol 2017;30:277-283 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - September 7, 2017 Category: Dermatology Source Type: research
Sea Buckthorn (Hippopha ë rhamnoides L.) Oil Improves Atopic Dermatitis-Like Skin Lesions via Inhibition of NF- & #x03BA;B and STAT1 Activation
Conclusion: These results suggest that SBT oil had a beneficial effect on AD-like skin lesions, partially via inhibition of the Th2 chemokines TARC and MDC in inflamed skin.Skin Pharmacol Physiol 2017;30:268-276 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - September 6, 2017 Category: Dermatology Source Type: research
Sea Buckthorn ( < b > < i > Hippopha ë rhamnoides < /i > < /b > L.) Oil Improves Atopic Dermatitis-Like Skin Lesions via Inhibition of NF- & #x03BA;B and STAT1 Activation
Conclusion: These results suggest that SBT oil had a beneficial effect on AD-like skin lesions, partially via inhibition of the Th2 chemokines TARC and MDC in inflamed skin.Skin Pharmacol Physiol 2017;30:268-276 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - September 5, 2017 Category: Dermatology Source Type: research
Impact of Body Site, Age, and Gender on the Collagen/Elastin Index by Noninvasive in vivo Vertical Two-Photon Microscopy
Background/Aims: Extrinsic and intrinsic skin aging is subject to constant remodeling and degradation processes, primarily in components of the extracellular matrix. While collagen fibers thin out during the aging process, the amorphous elastin fibers accumulate. These are essential formative components of the dermis. So far, these processes have been detected in vertical histological sections of invasive biopsies and recently in noninvasive horizontal scans.Methods: In this pilot study, a modified noninvasive 2-photon microscope was applied to measure the collagen/elastin index of skin in vivo. The obtained images permit ...
Source: Skin Pharmacology and Physiology - August 11, 2017 Category: Dermatology Source Type: research
