Histamine Iontophoresis as in vivo Model to Study Human Skin Inflammation with Minimal Barrier Impairment: Pilot Study Results of Application of the Model to a Sensitive Skin Panel
Conclusion: Histamine iontophoresis is a well-standardized in vivo model to quantitatively study the early stages of cutaneous inflammation with minimal impact on the skin barrier. In line with previous studies, it highlighted increased sensory perceptions in SS.Skin Pharmacol Physiol 2017;30:246-259 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - July 26, 2017 Category: Dermatology Source Type: research
Comparison of the Skin Penetration of 3 Metabolically Stable Chemicals Using Fresh and Frozen Human Skin
Conclusion: The penetration of the 3 chemicals was essentially unaffected by freezing the skin at -20 °C for up to 12 weeks.Skin Pharmacol Physiol 2017;30:234-245 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - July 26, 2017 Category: Dermatology Source Type: research
A Randomized Controlled Trial of Green Tea Beverages on the in vivo Radical Scavenging Activity in Human Skin
Conclusion: The results show that green tea enhances the radical scavenging capacity of the skin and support the hypothesis that green tea may offer protection against cutaneous oxidative stress.Skin Pharmacol Physiol 2017;30:225-233 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - July 19, 2017 Category: Dermatology Source Type: research
Sirtuins in Skin and Skin Cancers
The sirtuins are a family of proteins that comprise class III of the histone deacetylases. These NAD+-dependent proteins have been found to be intricately involved in a variety of important and skin-relevant cellular functions and processes, including aging, UV damage response, oxidative stress, and wound repair. In addition, recent research is unraveling the role of sirtuins in a variety of skin diseases, including melanoma and nonmelanoma skin cancers. In this review, we provide a discussion on the potential roles and implications of different sirtuins in skin-specific cellular processes, which may have relevance to skin...
Source: Skin Pharmacology and Physiology - July 13, 2017 Category: Dermatology Source Type: research
The Importance of 11 α-OH, 15-oxo, and 16-en Moieties of 11α-Hydroxy-15-oxo-kaur-16-en-19-oic Acid in Its Inhibitory Activity on Melanogenesis
In this study, we found thatent-11 α-hydroxy-15-oxo-kaur-16-en-19-oic acid (11α-OH KA) inPteris dispar Kunze strongly inhibited melanin synthesis by suppressingtyrosinase gene expression. The melanogenic transcription factor microphthalmia-associated transcription factor (MITF) is required for this suppression. However, 11 α-OH KA did not modulate the expression level or activity of MITF. Structure-activity relationship analyses suggested that the 11α-OH, 15-oxo, and 16-en moieties of 11α-OH KA are essential for the suppression of melanin synthesis. On the other hand, the 19-COOH moiety is important for preventing cel...
Source: Skin Pharmacology and Physiology - July 11, 2017 Category: Dermatology Source Type: research
Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia
Conclusions: Polymeric nanoparticles, prepared by using a modified method of the emulsification/solvent diffusion, showed a mean particle size around 300 nm, which may be sufficient for reaching the dermis and hair follicles and negative zeta potential values. Scanning electron microscope measurements showed that all the polymeric nanoparticles exhibited a spherical shape and a smooth surface regardless of their composition. A high encapsulation efficiency was achieved for FNS (79.49 ± 0.47%). In vitro release assays in physiological conditions demonstrated that nanoparticles yielded a prolonged release of FNS for 3 h. Sk...
Source: Skin Pharmacology and Physiology - July 7, 2017 Category: Dermatology Source Type: research
Antimelanogenic Efficacy of Melasolv (3,4,5-Trimethoxycinnamate Thymol Ester) in Melanocytes and Three-Dimensional Human Skin Equivalent
Conclusion: Our study showed that Melasolv clearly exerts a whitening effect on various melanocytes and human skin equivalent. These results suggest the possibility that Melasolv can be used as a depigmentary agent to treat pigmentary disorders as well as an active ingredient in cosmetics to increase whitening efficacy.Skin Pharmacol Physiol 2017;30:190-196 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - June 29, 2017 Category: Dermatology Source Type: research
Development of a Perfusion Platform for Dynamic Cultivation of in vitro Skin Models
Reconstructed skin models are suitable test systems for toxicity testing and for basic investigations on (patho-)physiological aspects of human skin. Reconstructed human skin, however, has clear limitations such as the lack of immune cells and a significantly weaker skin barrier function compared to native human skin. Potential reasons for the latter might be the lack of mechanical forces during skin model cultivation which is performed classically in static well-plate setups. Mechanical forces and shear stress have a major impact on tissue formation and, hence, tissue engineering. In the present work, a perfusion platform...
Source: Skin Pharmacology and Physiology - June 26, 2017 Category: Dermatology Source Type: research
Development of an in vitro Test Procedure to Determine the Direct Infrared A Protection of Sunscreens and Non-Cosmetic Samples
Conclusion: The applicability of the IRA emission of the light source, the spectral detector, transmissivity of the filter systems and the sample carriers could be validated. This experimental set-up can be used as an in vitro test procedure for the determination of direct IRA protection.Skin Pharmacol Physiol 2017;30:171-179 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - May 30, 2017 Category: Dermatology Source Type: research
Development of a Synthetic Substrate for the in vitro Performance Testing of Sunscreens
Conclusion: This workdemonstrates the possibilities of using alternative polymers for synthetic substrates for in vitro sunscreen testing.Skin Pharmacol Physiol 2017;30:159-170 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - May 23, 2017 Category: Dermatology Source Type: research
An Insight into the Changes in Skin Texture and Properties following Dietary Intervention with a Nutricosmeceutical Containing a Blend of Collagen Bioactive Peptides and Antioxidants
Conclusions: Overall, we demonstrated a significant increase in skin elasticity (+7.5%),p≤ 0.001 and an improvement in skin texture after daily oral consumption of the nutricosmeceutical. We also obtained a positive patient feedback through the self-assessment questionnaires. Taken together these results show that this nutricosmeceutical supplement may have photo-protective effects an d help improve skin health.Skin Pharmacol Physiol 2017;30:146-158 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - May 19, 2017 Category: Dermatology Source Type: research
Comparison of Occlusive and Open Application in a Psoriasis Plaque Test Design, Exemplarily Using Investigations of Mapracorat 0.1% Ointment versus Vehicle and Reference Drugs
Conclusion: Taking the higher technical challenges for the open PPT into account, we recommend the occluded PPT as a standard screening setting in early drug development. In special cases, considering certain drug aspects or study objectives that would require procedural adaptations, an open PPT could be the better-suited design. Finally, both PPT models show clear advantages: classification as phase I studies, small number of psoriatic subjects, relatively short study duration, excellent discrimination between compounds and concentrations, parallel measurement of treatment response, and go/no go decisions very early in cl...
Source: Skin Pharmacology and Physiology - April 25, 2017 Category: Dermatology Source Type: research
Excessive Weight Favours Skin Physiology - Up to a Point: Another Expression of the Obesity Paradox
Conclusion: Results suggest that excessive weight might favour skin performance within certain limits, reflecting a particular adaptation of the skin to the weight gain and body contour.Skin Pharmacol Physiol 2017;30:94-101 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - April 19, 2017 Category: Dermatology Source Type: research
Topical Histamine Stimulates Repigmentation of Nonsegmental Vitiligo by a Receptor-Dependent Mechanism
Conclusions: These studies indicate that topical histamine or an H2r agonist could be useful for treating nonsegmental vitiligo, but further clinical studies in large populations will be required to validate the efficacy and safety of this approach.Skin Pharmacol Physiol 2017;30:139-145 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - April 18, 2017 Category: Dermatology Source Type: research
Comparison of Occlusive and Open Application in a Psoriasis Plaque Test Design, Examplarily Using Investigations of Mapracorat 0.1% Ointment versus Vehicle and Reference Drugs
Conclusion: Taking the higher technical challenges for the open PPT into account, we recommend the occluded PPT as a standard screening setting in early drug development. In special cases, considering certain drug aspects or study objectives that would require procedural adaptations, an open PPT could be the better-suited design. Finally, both PPT models show clear advantages: classification as phase I studies, small number of psoriatic subjects, relatively short study duration, excellent discrimination between compounds and concentrations, parallel measurement of treatment response, and go/no go decisions very early in cl...
Source: Skin Pharmacology and Physiology - April 13, 2017 Category: Dermatology Source Type: research
