Skin Care in Neonates and Infants: A Scoping Review
The objective of this scoping review was to obtain an overview about the evidence of skin care activities in neonates and infants. Studies from 2010 were eligible if the population was (skin) healthy neonates and infants; if the concept was skin care interventions; and if the context was at home, in a community setting, in a pediatric outpatient service, or in a hospital. We searched for the literature via OVID in MEDLINE and Embase, in the Cochrane Library, in trial registries and for gray literature.Summary: We identified 42 studies since 2010, which examined four main skin care interventions: bathing, wiping, washing, a...
Source: Skin Pharmacology and Physiology - February 7, 2023 Category: Dermatology Source Type: research
Skin care in neonates and infants - a scoping review
Background
Skin care is a basic, daily activity performed by formal and informal caregivers from birth until end of life. Skin care activities are influenced by different factors as e.g., culture, knowledge, industrial developments and marketing activities. Therefore, various preferences, traditions and behaviours exist worldwide including skin care of neonates and infants. Objective of this scoping review was to obtain an overview about the evidence of skin care activities in neonates and infants. Studies from 2010 were eligible if the population were (skin) healthy neonates and infants, if the concept were skin care int...
Source: Skin Pharmacology and Physiology - February 7, 2023 Category: Dermatology Source Type: research
MAPK/AP-1 Signaling Pathway Is Involved in the Protection Mechanism of Bone Marrow Mesenchymal Stem Cells-Derived Exosomes against Ultraviolet-Induced Photoaging in Human Dermal Fibroblasts
Conclusion: BMSCs-exo protected HDFs against UVB-induced inhibition of cell viability and the activation of cell oxidative stress and inflammation, which might be related to the inhibition of the MAPK/AP-1 signaling pathway.Skin Pharmacol Physiol 2023;36:98 –105 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 6, 2023 Category: Dermatology Source Type: research
MAPK/AP-1 signaling pathway is involved in the protection mechanism of bone marrow mesenchymal stem cells-derived exosomes against Ultraviolet-induced photoaging in human dermal fibroblasts
Conclusion: BMSCs-exo protected HDFs against UVB-induced inhibition of cell viability and the activation of cell oxidative stress and inflammation, which might be related to the inhibition of the MAPK/AP-1 signaling pathway. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 6, 2023 Category: Dermatology Source Type: research
Permethrin Steal Effect by Unmasked Corneocytic Keratin in Topical Therapy of Scabies
Conclusion: The results provide further evidence for a relevant pharmacokinetic influencing factor in the epicutaneous application of permethrin and a rationale for the necessity of keratolytic pretreatment in hyperkeratotic skin for the effective use of topical permethrin application in scabies.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 30, 2023 Category: Dermatology Source Type: research
Permethrin steal effect by unmasked corneocytic keratin in topical therapy of scabies
Conclusion: The results provide further evidence for a relevant pharmacokinetic influencing factor in the epicutaneous application of permethrin and a rationale for the necessity of keratolytic pretreatment in hyperkeratotic skin for the effective use of topical permethrin application in scabies. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 30, 2023 Category: Dermatology Source Type: research
Application of Topical Sandalore ® Increases Epidermal Dermcidin Synthesis in Organ-Cultured Human Skin ex vivo
Conclusion: In addition to demonstrating for the first time that DCD can be expressed by epidermal keratinocytes, our pilot study suggests that topical treatment of human skin with a cosmetic odorant (Sandalore ®) has the potential to alter the composition of the human skin microbiome through the selective upregulation of DCD. If confirmed, Sandalore® could become an attractive adjuvant, nondrug treatment for dermatoses characterized by dysbiosis due to overgrowth ofS. aureus andMalassezia, such as atopic dermatitis and seborrheic dermatitis.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 26, 2023 Category: Dermatology Source Type: research
Application of topical Sandalore ® increases epidermal dermcidin synthesis in organ-cultured human skin ex vivo.
Introduction: Several olfactory receptors (ORs) are expressed in human skin, where they regulate skin pigmentation, barrier function, wound healing, and hair growth. Previously, we found that the selective activation of OR family 2 subfamily AT member 4 (OR2AT4) by the synthetic, sandalwood-like odorant, Sandalore ®, differentially stimulates the expression of antimicrobial peptides (AMPs) in human scalp hair follicle epithelium ex vivo. As OR2AT4 is also expressed by epidermal keratinocytes, we hypothesized that it may modulate intraepidermal AMP synthesis, thereby contributing to skin microbiome management .
Methods: We...
Source: Skin Pharmacology and Physiology - January 26, 2023 Category: Dermatology Source Type: research
Microinjury-Induced Tumor Necrosis Factor- α Surge Stimulates Hair Regeneration in Mice
Conclusion: Our findings indicate that microinjury stimulates the wound-healing mechanism via TNF- α/Wnt/VEGF surge to induce hair growth, and that blocking TNF-α inhibits this growth process.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 24, 2023 Category: Dermatology Source Type: research
Histamine skin prick tests: from established diagnostic technique to advanced experimental biomarker
Introduction
Skin prick tests have a long history as diagnostic and pharmacodynamic biomarker. Besides visual assessments of the wheal and flare, objective blood flow measurements using laser Doppler imaging (LDI) and laser speckle contrast imaging (LSCI) have been reported. In light of these advancements, an up-to-date characterization of the histamine-evoked response is worthwhile.
Methods
A single-center study was completed in healthy males. Two parameters were addressed: (1) dermal blood flow (DBF) within a 7.65 mm ring encircling the skin prick site (DBFring), and (2) surface area of the flare (AREAflare).
First, ...
Source: Skin Pharmacology and Physiology - January 9, 2023 Category: Dermatology Source Type: research
A Phase I Study to Evaluate the Safety and Pharmacokinetics of SHR0302 Base Ointment in Healthy Adult Volunteers
Conclusion: The SHR0302 base ointment (either single or multiple doses) was well tolerated and safe, with no racial disparity. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - December 29, 2022 Category: Dermatology Source Type: research
Development of an efficient extraction methodology to analyse potential inflammatory biomarkers from sebum
Conclusion:
The study revealed that there was a high degree of variability in the extraction efficiency of different cytokines. However, improved efficiency was achieved across all cyto kines with selective surfactants and mechanical stimuli. The optimised protocol will provide means to detect low levels of potential biomarkers from skin surface, enabling the evaluation of local changes in pro- and anti-inflammatory cytokines present in different skin conditions. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - December 26, 2022 Category: Dermatology Source Type: research
Contents Vol. 35, 2022
Skin Pharmacol Physiol 2022;35:I –IV (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - December 13, 2022 Category: Dermatology Source Type: research
Acknowledgement to the Reviewers
Skin Pharmacol Physiol 2022;35:354 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - December 13, 2022 Category: Dermatology Source Type: research
Trichoscopic diagnosis of structural hair defects in a clinical setting: A Cross-sectional analytical study
Conclusion: Most hair shaft abnormalities can be reliably diagnosed with high accuracy using a handheld dermoscope in an office setting. Skillful knowledge of Dermoscopy is an important aid in diagnosis of hair and scalp disorders. (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - December 5, 2022 Category: Dermatology Source Type: research
