Lipid Loss Increases Stratum Corneum Stress and Drying Rates
Conclusions: These results suggest that lipid loss causes marked increases in SC drying stresses, which may in turn contribute to changes in skin perception. NMF extraction may be important in vivo, but has remarkably little impact in isolated SC.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - September 3, 2020 Category: Dermatology Source Type: research
< b > < i > JAK1 < /i > < /b > rs310241 and < b > < i > JAK3 < /i > < /b > rs3008 Genotypes May Increase Susceptibility to Psoriasis: A Case Control Study
Conclusion: The results indicate a possible association betweenJAK1 rs310241 andJAK3 rs3008 gene polymorphisms and susceptibility to psoriasis. These findings validate the importance of these molecules in psoriasis and may enable the identification of the individuals most susceptible to the disease.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - September 2, 2020 Category: Dermatology Source Type: research
Evaluation of a Product Containing Xyloglucan and Pea Protein on Skin Barrier Permeability
Conclusion: In summary, we demonstrated that the product containing XG and PP was able to maintain barrier permeability preserving its integrity, and therefore, it can be considered as an interesting approach for the management of epidermis-related diseases.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - August 26, 2020 Category: Dermatology Source Type: research
Inter- α-Trypsin Inhibitor Heavy Chain 5 (ITIH5) Is a Natural Stabilizer of Hyaluronan That Modulates Biological Processes in the Skin
Conclusion: Taken together, our experiments revealed that ITIH5 forms complexes with HA, thereby on the one hand stabilizing HA and facilitating the formation of ECM structures and on the other hand modulating inflammatory responses.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - August 14, 2020 Category: Dermatology Source Type: research
State of the Art in Stratum Corneum Research. Part II: Hypothetical Stratum Corneum Lipid Matrix Models
This review is the second part of a series which presents the state of the art in stratum corneum (SC) lipid matrix (LM) research in depth. In this part, the various hypothetical models which were developed to describe the structure and function of the SC LM as the skin ’s barrier will be discussed. New as well as a cumulative assortment of older results which change the view on the different models are considered to conclude how well the different models are holding up today. As a final conclusion, a model, factoring in as much of the known data as possible, is concluded, unifying the varying different models into one w...
Source: Skin Pharmacology and Physiology - July 17, 2020 Category: Dermatology Source Type: research
Epidermal Regeneration Induced by Comfrey Extract: A Study by Light and Electron Microscopy
Conclusions: Application of comfrey cream led to a quicker regeneration of skin cells and to an earlier differentiation of the cells towards a normal fine structure with a visible distinction of epidermal strata, keratin, and corneocyte formation within 4 –7 days. The study covered the early days of skin regeneration and confirms the benefits observed in published clinical trials and non-interventional studies in patients with abrasions.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - July 17, 2020 Category: Dermatology Source Type: research
A Novel Autologous Topical Serum Based on Plasma Rich in Growth Factors Technology Counteracts Ultraviolet Light-Derived Photo-Oxidative Stress
Conclusion: This preliminary study suggests that this novel ATS might counteract the harmful effects of UV radiation.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - July 1, 2020 Category: Dermatology Source Type: research
Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review
Caffeine, particularly after ingestion, is well known to exert various pharmacological effects. A growing body of evidence implicates the ingestion of caffeine with beneficial effects on several diseases. The easy penetration of caffeine across the skin barrier and into human skin makes caffeine an ideal compound for topical application. Hair loss is known to negatively affect the quality of life and predispose to depression and anxiety. Androgenetic alopecia (AGA) is the most common type of hair loss in both men and women. To date, only few approved drug-based treatments for AGA exist, and these are inevitably associated ...
Source: Skin Pharmacology and Physiology - June 29, 2020 Category: Dermatology Source Type: research
Vascular Endothelial Growth Factor Blockade Induces Dermal Endothelial Cell Apoptosis in a Clinically Relevant Skin Organ Culture Model
Conclusion: Our pilot study provides the first evidence that anti-VEGF therapy promotes endothelial cell apoptosis in human skin ex vivo. Our pragmatic human skin organ culture assay offers a valuable tool for future preclinical endothelial cell and translational microvascular network/anti-angiogenesis research in human skin.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - June 22, 2020 Category: Dermatology Source Type: research
The Effects of Fabric Containing < b > < i > Chamaecyparis obtusa < /i > < /b > Essential Oil on Atopic Dermatitis-Like Lesions: A Functional Clothing Possibility
Conclusions: It was confirmed that fabric containing EOCO has anti-atopic and anti-inflammatory properties. The study data show that fabric containing EOCO can be implemented as an alternative functional clothing for people suffering from AD.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - June 12, 2020 Category: Dermatology Source Type: research
Hydrogen Sulfide Promotes Cell Proliferation and Melanin Synthesis in Primary Human Epidermal Melanocytes
Conclusions: This study demonstrates that H2S promotes cell proliferation and melanin synthesis in HEMs, which indicates pharmacologic regulation of H2S may be potential treatment for skin disorders caused by loss of melanocytes or dysfunction of melanogenesis.Skin Pharmacol Physiol 2020;33:61 –68 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - June 2, 2020 Category: Dermatology Source Type: research
A Clinical Anti-Ageing Comparative Study of 0.3 and 0.5% Retinol Serums: A Clinically Controlled Trial
Conclusion: Retinol in liquid crystal formulation is safe and provides significant clinical benefits associated with unification of skin colour, overall skin tone, skin elasticity, and moisture. Regular use of retinol typically results in brightening of the skin and reduced signs of ageing. The objective findings confirmed the effectiveness of the procedures.Skin Pharmacol Physiol 2020;33:102 –116 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - May 19, 2020 Category: Dermatology Source Type: research
Altered Epidermal Permeability Barrier Function in the Uninvolved Skin Supports a Role of Epidermal Dysfunction in the Pathogenesis of Occupational Hand Eczema
In conclusion, the uninvolved skin site of subjects with hand eczema exhibits abnormalities in epidermal perme ability barrier, supporting a pathogenic role of epidermal dysfunction in hand eczema. Whether subjects with hand eczema in other occupations also display altered epidermal function on uninvolved skin remains to be explored.Skin Pharmacol Physiol 2020;33:94 –101 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 30, 2020 Category: Dermatology Source Type: research
Solvent-Containing Closure Material Can Be Used to Prevent Follicular Penetration of Caffeine and Fluorescein Sodium Salt on Porcine Ear Skin
Conclusion: This study clearly demonstrates that a standard nail varnish in combination with a gentle application technique of the API provides a secure follicular closure. The presented study only investigated the closure for the substances caffeine and fluorescein sodium salt. The results might not be transferable to all kinds of APIs.Skin Pharmacol Physiol 2020;33:117 –125 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - February 11, 2020 Category: Dermatology Source Type: research
