Intradermal Administration of Atrial Natriuretic Peptide Attenuates Cutaneous Vasodilation but Not Sweating in Young Men during Exercise in the Heat
Conclusion: Intradermal ANP administration directly attenuated cutaneous blood flow, but not sweating, in habitually active young men during rest and exercise in the heat.Skin Pharmacol Physiol 2020;33:86 –93 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 31, 2020 Category: Dermatology Source Type: research
The Influence of Short-Wave and Long-Wave Radiation Spectrum on the Photostability of Sunscreens
Conclusion:Based on these data, we can conclude that short waves and/or VIS + IR light have an influence on the photostability of sunscreens.Skin Pharmacol Physiol 2020;33:77 –85 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 24, 2020 Category: Dermatology Source Type: research
Exogenous Activation of Protease-Activated Receptor 2 Attenuates Cutaneous Vasodilatation and Sweating in Older Men Exercising in the Heat
Conclusion: We show that while exogenous PAR2 activation induces cutaneous vasodilatation at rest under non-heat-stressed conditions, it attenuates cutaneous vasodilatation and sweating during and following an exercise-induced heat stress in older men.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - June 20, 2019 Category: Dermatology Source Type: research
Formulation and Artificial Sebum Effects on the Percutaneous Absorption of Zinc Pyrithione through Excised Human Skin
Conclusion: These data are consistent with the hypothesis that ZnPT percutaneous absorption, as measured by [14C]PT kinetics, is controlled by particle dissolution and molecular speciation.Skin Pharmacol Physiol 2019;32:1 –11 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - June 14, 2019 Category: Dermatology Source Type: research
Comparison of Skin Structural and Functional Parameters in Well-Nourished and Moderately Undernourished Infants
Conclusion: These findings reveal a greater impact of moderate undernutrition on the development of the dermis and subcutis and suggest that critical epidermal functions such as skin barrier and pH are mostly maintained.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - June 5, 2019 Category: Dermatology Source Type: research
A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Oral Administration of a Heat-Treated < b > < i > Lactobacillus paracasei < /i > < /b > Supplement in Infants with Atopic Dermatitis Receiving Topical Corticosteroid Therapy
Conclusions: In this design, the probioticL. paracasei was not beneficial as a complementary approach to topical corticosteroids in infants with AD. However, slight beneficial effects may have been masked by the moderate potency corticoid.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - May 23, 2019 Category: Dermatology Source Type: research
Atopic Patients Show Increased Interleukin 4 Plasma Levels but the Degree of Elevation Is Not Sufficient to Upregulate Interleukin-4-Sensitive Genes
Conclusion: Our data suggest that the IL-4 plasma levels of atopic patients are not high enough to impact the expression of IL-4-sensitive genes.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - May 17, 2019 Category: Dermatology Source Type: research
Evaluation of Quantum Dot Skin Penetration in Porcine Skin: Effect of Age and Anatomical Site of Topical Application
Conclusions: There is minimal penetration of QDs through pig skin. Density and diameter of follicles in association with age of pigs and application site influenced the amount of QDs deposited in follicles. The structure of the stratum corneum, follicle density and diameter of NBPS are similar to human skin suggesting that NBPS is an appropriate model for human skin in the evaluation of topical applications of a range of chemicals including nanosystems.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - May 14, 2019 Category: Dermatology Source Type: research
Nrf2 Activation by SK-119 Attenuates Oxidative Stress, UVB, and LPS-Induced Damage
Conclusion: These results indicate that SK-119 is an Nrf2 activator that can be used as a prototype molecule for the development of novel treatments of dermatological disorders related to oxidative stress.Skin Pharmacol Physiol (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - May 10, 2019 Category: Dermatology Source Type: research
Side Effects of Frequently Used Antihypertensive Drugs on Wound Healing in vitro
Conclusion: Antihypertensive drugs have an influence on keratinocytes and fibroblasts; they are not neutral. Candesartan has the most positive effects on skin cells. For angiotensin-converting enzyme inhibitors and thiazide diuretics, wound healing in a 3D model is delayed. β-Receptor blockers seem to improve wound healing to a small extent just like calcium channel blockers. These results should be evaluated in a clinical trial to verify their clinical relevance.Skin Pharmacol Physiol 2019;32:162 –172 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - April 24, 2019 Category: Dermatology Source Type: research
Dermal Peptide Delivery Using Enhancer Molecules and Colloidal Carrier Systems – Part IV: Search for an Alternative Model Membrane for Future ATR Permeation Studies Using PKEK as the Model Substance
The main barrier of the human skin is the stratum corneum (SC). Its properties (also depending on the health and age of the individual) and its influence on improved penetration of active ingredients into the skin are the subject of many research projects. Since the availability of human skin, as the ideal model membrane, is limited, the aim of this study was to find a suitable alternative model membrane from the animal kingdom. The alternative model membrane should be used in subsequent permeation experiments with the Teflon diffusion cell instead of human SC. Previous studies have already investigated the permeation prop...
Source: Skin Pharmacology and Physiology - April 4, 2019 Category: Dermatology Source Type: research
Permeation Mechanism of Caffeine and Naproxen through in vitro Human Epidermis: Effect of Vehicles and Penetration Enhancers
Conclusion: A permeation enhancer-induced alteration in diffusivity, rather than effects on SC solubility, was the main driving force behind increases in permeation flux of the hydrophilic molecule caffeine. For the more the lipophilic molecule naproxen, increased SC solubility drove the increases in permeation flux.Skin Pharmacol Physiol 2019;32:132 –141 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 31, 2019 Category: Dermatology Source Type: research
Noninvasive Determination of Epidermal and Stratum Corneum Thickness in vivo Using Two-Photon Microscopy and Optical Coherence Tomography: Impact of Body Area, Age, and Gender
Conclusion: 2PM provides a noninvasive method for imaging the epidermis and especially the SC in vivo and is optimally suited for the application of histological criteria.Skin Pharmacol Physiol 2019;32:142 –150 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 31, 2019 Category: Dermatology Source Type: research
Analysis of the Effect of Serum Estradiol Concentration on Facial Skin Moisture, Pore Width, Discoloration and Smoothness in 16- to 50-Year-Old Women at the 5th and 25th Days of the Menstrual Cycle
Conclusions: Skin moisture was related to the concentration of estradiol only in the oldest examined group of women regardless of the phase of menstrual cycle. In the 40- to 50-year-old group of women, the low level of estradiol on the 25th day of the cycle is better used to maintain a good facial skin appearance and has a positive influence not only on skin moisture, but also on pore width and skin smoothness.Skin Pharmacol Physiol 2019;32:125 –131 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 22, 2019 Category: Dermatology Source Type: research
Use of a Simple in vitro Test to Assess Loss of Chemical due to Volatility during an in vitro Human Skin Absorption Study
Conclusion: Our data support the use of a quick and simple test for volatility to account for the loss of MB in skin penetration experiment due to volatility. The best parameter to indicate the potential of a chemical to evaporate is the VP.Skin Pharmacol Physiol 2019;32:117 –124 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - March 20, 2019 Category: Dermatology Source Type: research
