In vitro Evaluation of the Cleansing Effect of a Monofilament Fiber Debridement Pad Compared to Gauze Swabs
Background: Removal of nonvital tissue is an accepted method to eradicate biofilms and to stimulate wound healing. Debridement using a monofilament polyester fiber pad has clinically been shown to be effective as well as pain and trauma free.Methods: For in vitro determination of the cleansing capacity of this product compared to gauze swabs, a wound debridement model was used with glass plates coated with a bovine serum albumin solution, stained with hematoxylin. Both products were moistened and fixed to a weight connected to a regulated motor and were then pulled over the holding device with the coated glass plate under ...
Source: Skin Pharmacology and Physiology - January 17, 2017 Category: Dermatology Source Type: research
Effects of Aloe Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial
Conclusion: The results suggest that continuedAloe sterol ingestion contributes to maintaining healthy skin.Skin Pharmacol Physiol 2016;29:309-317 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 16, 2017 Category: Dermatology Source Type: research
Effects of < b > < i > Aloe < /i > < /b > Sterol Supplementation on Skin Elasticity, Hydration, and Collagen Score: A 12-Week Double-Blind, Randomized, Controlled Trial
Conclusion: The results suggest that continuedAloe sterol ingestion contributes to maintaining healthy skin.Skin Pharmacol Physiol 2016;29:309-317 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 13, 2017 Category: Dermatology Source Type: research
In vitro Dermal Absorption of Hydroquinone: Protocol Validation and Applicability on Illegal Skin-Whitening Cosmetics
In Europe, hydroquinone is a forbidden cosmetic ingredient. It is, however, still abundantly used because of its effective skin-whitening properties. The question arises as to whether the quantities of hydroquinone used become systemically available and may cause damage to human health. Dermal absorption studies can provide this information. In the EU, dermal absorption has to be assessed in vitro since the Cosmetic Regulation 1223/2009/EC forbids the use of animals. To obtain human-relevant data, a Franz diffusion cell protocol was validated using human skin. The results obtained were comparable to those from a multicentr...
Source: Skin Pharmacology and Physiology - January 4, 2017 Category: Dermatology Source Type: research
Skin Surface Topography and Texture Analysis of Sun-Exposed Body Sites in View of Sunscreen Application
Conclusions: Different site-age combinations show significant variation of skin surface roughness. The application of sunscreen may in some instances need to be adjusted to take into account the increased roughness of highly sun-exposed anatomical sites.Skin Pharmacol Physiol 2016;29:291-299 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - January 4, 2017 Category: Dermatology Source Type: research
Synthesis of a Sulfonimidamide-Based Analog of Tasisulam and Its Biological Evaluation in the Melanoma Cell Lines SKMel23 and A375
Tasisulam is a promising antitumor agent with complex pharmacology, which is used as an antiproliferative agent in patients with metastatic melanoma and other solid tumors. Phase 2 melanoma studies showed promising results but had to be stopped because of insufficient tasisulam clearance leading to toxic side effects. To reduce the negative effects of tasisulam, we synthesized a novel sulfonimidamide-based analog to evaluate its antiproliferative effects in comparison to the original compound by performing a cell proliferation assay in melanoma cell lines SKMel23 and A375. The results revealed that the analog had inhibitor...
Source: Skin Pharmacology and Physiology - December 23, 2016 Category: Dermatology Source Type: research
Erratum
Skin Pharmacol Physiol 2016;29:280 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - December 21, 2016 Category: Dermatology Source Type: research
Ex vivo Cutaneous Bioavailability of Topical Mometasone Furoate in an O/W Preparation
Mometasone furoate (MMF) is a modern glucocorticoid of the 4th generation, which has been proven not only for inhalation but also for cutaneous treatment. Due to its lipophilic character, it is mainly used in ointments and creams with an outer lipophilic phase (W/O type). However, this study investigated the cutaneous cytotoxicology of MMF and tried to characterize its pharmacokinetic effects on the skin using an O/W preparation. An HPLC method has been developed and validated for the detection of MMF in cutaneous tissue, and concentration-time curves of MMF were created after cutaneous application on unaffected as well as...
Source: Skin Pharmacology and Physiology - December 7, 2016 Category: Dermatology Source Type: research
The Influence of Two Different Foam Creams on Skin Barrier Repair of Foot Xerosis: A Prospective, Double-Blind, Randomised, Placebo-Controlled Intra-Individual Study
Conclusion: This study shows that a quick reorganisation of the SC lipids initiates a good restoration of the whole skin barrier after 4 weeks of treatment with a foam cream.Skin Pharmacol Physiol 2016;29:266-272 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - November 22, 2016 Category: Dermatology Source Type: research
Dose- and Time-Dependent Cellular Effects of Cold Atmospheric Pressure Plasma Evaluated in 3D Skin Models
Conclusions: Treatment of 3D skin models with the plasma MEF nozzle using air or nitrogen is reported. A clearly dose- and time-dependent effect of CAPs could be observed in which the CAP based on nitrogen exhibited higher cell compatibility than the CAP generated from air. These settings might be recommended for medical in vivo applications such as wound decontamination.Skin Pharmacol Physiol 2016;29:257-265 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - November 3, 2016 Category: Dermatology Source Type: research
In vivo anti-Trichophyton Activities of Seed Oil Obtained from Caraganakorshinskii Kom.
Conclusion: Seed oil of C.korshinskii demonstrated high antifungal efficacy in experimental dermatophytosis.Skin Pharmacol Physiol 2016;29:243-249 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - September 16, 2016 Category: Dermatology Source Type: research
Ex vivo Skin Permeation of Betulin from Water-in-Oil Foams
Triterpenes of the outer bark of birch are known to improve wound healing. An oleogel with these triterpenes as active principle is approved by the European Medicines Agency. As foams can be applied without touching the skin, they might be an advantageous application form. A comparable wound-healing effect can be expected when the permeation flux of the triterpenes from different types of formulations, namely oleogels, water-in-oil emulsions and water-in-oil foams, is similar. The tested formulations were based on three lipids (medium-chain trigylcerides, sunflower oil and paraffin) which differ in their polarity and solve...
Source: Skin Pharmacology and Physiology - September 15, 2016 Category: Dermatology Source Type: research
In vivo anti- < b > < i > Trichophyton < /i > < /b > Activities of Seed Oil Obtained from < b > < i > Caragana < /i > < /b > < b > < i > korshinskii < /i > < /b > Kom.
Conclusion: Seed oil of C.korshinskii demonstrated high antifungal efficacy in experimental dermatophytosis.Skin Pharmacol Physiol 2016;29:243-249 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - September 15, 2016 Category: Dermatology Source Type: research
The Effect of Glycation on Epidermal Lipid Content, Its Metabolism and Change in Barrier Function
Conclusion: Biological and physical change in the epidermis, especially upregulation of FA synthesis by glycation, contributed to barrier disruption, and inhibiting glycation may offer an effective treatment option for aged or glycated skin.Skin Pharmacol Physiol 2016;29:231-242 (Source: Skin Pharmacology and Physiology)
Source: Skin Pharmacology and Physiology - August 22, 2016 Category: Dermatology Source Type: research
Major Depression and Psoriasis: A Psychodermatological Phenomenon
Conclusion: Various neuroimmunological studies point towards the notion that depression and psoriasis are associated with each other. Melatonin has also been found to be associated with both conditions. A possibility exists that both conditions can cause each other due to the possible bidirectional relationship of psoriasis and major depression. However, if this is the case, then why all depressed patients fail to develop psoriasis and why all psoriatic patients fail to develop depression remains a question unanswered. We believe that future studies will unmask this mystery.Skin Pharmacol Physiol 2016;29:220-230 (Source: S...
Source: Skin Pharmacology and Physiology - August 18, 2016 Category: Dermatology Source Type: research
