Neurology Neuroimmunology and Neuroinflammation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Interleukin-6 Receptor Blockade in Treatment-Refractory MOG-IgG-Associated Disease and Neuromyelitis Optica Spectrum Disorders
This study provides Class III evidence that long-term TCZ therapy is safe and reduces relapse probability in MOGAD and AQP4-IgG+ NMOSD. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - November 16, 2021 Category: Neurology Authors: Ringelstein, M., Ayzenberg, I., Lindenblatt, G., Fischer, K., Gahlen, A., Novi, G., Hayward-Könnecke, H., Schippling, S., Rommer, P. S., Kornek, B., Zrzavy, T., Biotti, D., Ciron, J., Audoin, B., Berthele, A., Giglhuber, K., Zephir, H., Kü Tags: All Demyelinating disease (CNS), Devic's syndrome, Optic neuritis; see Neuro-ophthalmology/Optic Nerve, Transverse myelitis Article Source Type: research

Analysis of Macrophages and Peptidergic Fibers in the Skin of Patients With Painful Diabetic Polyneuropathy
This study examined the possible skin markers of painful diabetic polyneuropathy (P-DPN): macrophages, substance P (SP), and calcitonin gene-related peptide (CGRP). Methods The participants were included from a large Danish cross-sectional clinical study of type 2 diabetes. We diagnosed definite diabetic polyneuropathy using the Toronto criteria and used the Neuropathic Pain Special Interest Group classification for defining P-DPN. We included 60 skin biopsies from patients with diabetic polyneuropathy—30 with P-DPN and 30 with nonpainful diabetic polyneuropathy (NP-DPN)—and 30 biopsies from healthy controls o...
Source: Neurology Neuroimmunology and Neuroinflammation - November 11, 2021 Category: Neurology Authors: Gylfadottir, S. S., Itani, M., Kristensen, A. G., Tankisi, H., Jensen, T. S., Sindrup, S. H., Bennett, D., Nyengaard, J. R., Finnerup, N. B., Karlsson, P. Tags: Peripheral neuropathy, Neuropathic pain Article Source Type: research

Impact of Dietary Intervention on Serum Neurofilament Light Chain in Multiple Sclerosis
We examined sNfL levels of 40 participants at baseline and at the end of the study after 6 months using single molecule array assay. Results sNfL levels were investigated in 9 controls, 14 participants on CR, and 17 participants on AKD. Correlation analysis showed an association of sNfL with age and disease duration; an association was also found between sNfL and the Multiple Sclerosis Functional Composite. AKD significantly reduced sNfL levels at 6 months compared with the common diet group (p = 0.001). Discussion For clinical or study use, consider that AKD may incline sNfL levels independent of relapse activity up to ...
Source: Neurology Neuroimmunology and Neuroinflammation - November 11, 2021 Category: Neurology Authors: Bock, M., Steffen, F., Zipp, F., Bittner, S. Tags: Clinical trials Randomized controlled (CONSORT agreement), Class II, Multiple sclerosis Article Source Type: research

Nicolau Syndrome After Glatiramer Acetate Injection in Close Proximity to Administration of SARS-CoV-2 mRNA Vaccine
(Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - November 10, 2021 Category: Neurology Authors: Sy, M. Y., Fromm, E., Doan, L., Rojek, N., Brandt, A. U. Tags: Multiple sclerosis Clinical/Scientific Note Source Type: research

Decrease in Serum Anti-MAG Autoantibodies Is Associated With Therapy Response in Patients With Anti-MAG Neuropathy: Retrospective Study
The objective of the retrospective analysis was to test the hypothesis that changes in serum anti-myelin-associated glycoprotein (MAG) autoantibodies are associated with clinical response to immunotherapy in patients with anti-MAG neuropathy. Methods As of January 29, 2020, we used anti-myelin-associated glycoprotein-related search strings in the Medline database to identify studies that provided information on anti-MAG immunoglobulin M (IgM) autoantibodies and clinical outcomes during immunotherapies. The relative change in anti-MAG IgM titers, paraprotein levels, or total IgM was determined before, during, or posttreatm...
Source: Neurology Neuroimmunology and Neuroinflammation - November 10, 2021 Category: Neurology Authors: Hänggi, P., Aliu, B., Martin, K., Herrendorff, R., Steck, A. J. Tags: All Immunology, Peripheral neuropathy Article Source Type: research

B Cells in the CNS at Postmortem Are Associated With Worse Outcome and Cell Types in Multiple Sclerosis
Discussion Perivascular B cells were associated with worse clinical outcomes and CNS-compartmentalized inflammation. Our findings further support the concept of targeting compartmentalized B-cell inflammation in progressive MS. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - November 10, 2021 Category: Neurology Authors: Moccia, M., Haider, L., Eshaghi, A., van de Pavert, S. H. P., Brescia Morra, V., Patel, A., Wheeler-Kingshott, C. A. M., Barkhof, F., Ciccarelli, O. Tags: Multiple sclerosis Article Source Type: research

Anti-C2 Antibody ARGX-117 Inhibits Complement in a Disease Model for Multifocal Motor Neuropathy
Discussion Binding of IgM antibodies from patients with MMN to iPSC-derived MNs induces complement activation. By expressing complement regulatory proteins, particularly CD59, MNs are protected against complement-mediated lysis. Yet, because of expressing C3aR, the function of these cells may be affected by complement activation upstream of membrane attack complex formation. ARGX-117 inhibits complement activation upstream of C3 in this disease model for MMN and therefore represents an intervention strategy to prevent harmful effects of complement in MMN. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - November 10, 2021 Category: Neurology Authors: Budding, K., Johansen, L. E., Van de Walle, I., Dijkxhoorn, K., de Zeeuw, E., Bloemenkamp, L. M., Bos, J. W., Jansen, M. D., Curial, C. A. D., Silence, K., de Haard, H., Blanchetot, C., Van de Ven, L., Leusen, J. H. W., Pasterkamp, R. J., van den Berg, L. Tags: All Immunology, All Neuromuscular Disease Article Source Type: research

Targeted RNA Sequencing of VZV-Infected Brain Vascular Adventitial Fibroblasts Indicates That Amyloid May Be Involved in VZV Vasculopathy
Discussion Gene expression profiles and pathway enrichment analysis of VZV-infected HBVAFs, as well as phenotypic studies, reveal features of pathologic vascular remodeling (e.g., increased cell migration and changes in the extracellular matrix) that can contribute to cerebrovascular disease. Furthermore, the discovery of amyloid-associated transcriptional pathways and intracellular amyloid deposition in HBVAFs raise the possibility that VZV vasculopathy is an amyloid disease. Amyloid deposition may contribute to cell death and loss of vascular wall integrity, as well as potentiate chronic inflammation in VZV vasculopathy,...
Source: Neurology Neuroimmunology and Neuroinflammation - November 10, 2021 Category: Neurology Authors: Bubak, A. N., Como, C. N., Hassell, J. E., Mescher, T., Frietze, S. E., Niemeyer, C. S., Cohrs, R. J., Nagel, M. A. Tags: Vasculitis, Viral infections, All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia, Gene expression studies Article Source Type: research

Impact of COVID-19 in Immunosuppressed Children With Neuroimmunologic Disorders
Discussion In this cohort of children with neuroimmunologic disorders, the frequency of COVID-19 was low and not affected by immunosuppressive therapies. The main risk factors for developing COVID-19 were having cohabitants with COVID-19 and low vitamin D levels. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - November 10, 2021 Category: Neurology Authors: Olive-Cirera, G., Fonseca, E., Cantarin-Extremera, V., Vazquez-Lopez, M., Jimenez-Legido, M., Gonzalez-Alvarez, V., Ribeiro-Constante, J., Camacho-Salas, A., Marti, I., Cancho-Candela, R., Martinez-Gonzalez, M. J., Saiz, A., Armangue, T., on behalf of the Tags: Autoimmune diseases, All Pediatric, COVID-19, All Demyelinating disease (CNS) Article Source Type: research

COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context
Discussion Overall, the MS cohort had a risk of severe events that is twice the risk than the age- and sex-matched Italian population. This excess of risk is mainly explained by the EDSS score and comorbidities, whereas a residual increase of hospitalization risk was observed in patients on anti-CD20 therapies and a decrease in people on interferon. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - November 9, 2021 Category: Neurology Authors: Sormani, M. P., Schiavetti, I., Carmisciano, L., Cordioli, C., Filippi, M., Radaelli, M., Immovilli, P., Capobianco, M., De Rossi, N., Brichetto, G., Cocco, E., Scandellari, C., Cavalla, P., Pesci, I., Zito, A., Confalonieri, P., Marfia, G. A., Perini, P. Tags: COVID-19, Multiple sclerosis, Incidence studies, Risk factors in epidemiology Article Source Type: research

COVID-19 Vaccination Reactogenicity in Persons With Multiple Sclerosis
The objective of this retrospective cross-sectional study was to generate real-world multiple sclerosis–specific vaccine safety information, particularly in the context of specific DMTs, and provide information to mitigate specific concerns in vaccine hesitant PwMS. Methods Between 3/2021 and 6/2021, participants in iConquerMS, an online people-powered research network, reported SARS-CoV-2 vaccines, experiences of local (itch, pain, redness, swelling, or warmth at injection site) and systemic (fever, chills, fatigue, headache, joint pain, malaise, muscle ache, nausea, allergic, and other) reactions within 24 hours (...
Source: Neurology Neuroimmunology and Neuroinflammation - November 9, 2021 Category: Neurology Authors: Briggs, F. B. S., Mateen, F. J., Schmidt, H., Currie, K. M., Siefers, H. M., Crouthamel, S., Bebo, B. F., Fiol, J., Racke, M. K., O'Connor, K. C., Kolaczkowski, L. G., Klein, P., Loud, S., McBurney, R. N. Tags: Public health, Multiple sclerosis, All epidemiology Article Source Type: research

Clinical and Laboratory Features in Anti-NF155 Autoimmune Nodopathy
This study provides Class IV evidence that anti-NF155 antibodies associate with a specific phenotype and response to rituximab. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - November 2, 2021 Category: Neurology Authors: Martin-Aguilar, L., Lleixa, C., Pascual-Goni, E., Caballero-Avila, M., Martinez-Martinez, L., Diaz-Manera, J., Rojas-Garcia, R., Cortes-Vicente, E., Turon-Sans, J., de Luna, N., Suarez-Calvet, X., Gallardo, E., Rajabally, Y., Scotton, S., Jacobs, B. C., B Tags: Chronic inflammatory demyelinating polyneuropathy, Class IV Article Source Type: research

CCR5 Blockade in Inflammatory PML and PML-IRIS Associated With Chronic Inflammatory Diseases' Treatments
This study provides Class IV evidence showing that adding maraviroc to the management of iatrogenic iPML/PML-IRIS does not improve the outcome. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - November 2, 2021 Category: Neurology Authors: Bernard-Valnet, R., Moisset, X., Maubeuge, N., Lefebvre, M., Ouallet, J.-C., Roumier, M., Lebrun-Frenay, C., Ciron, J., Biotti, D., Clavelou, P., Godeau, B., Du Pasquier, R. A., Martin-Blondel, G. Tags: Viral infections, Class IV, Multiple sclerosis Article Source Type: research

GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder
Discussion GRP78 antibodies may be associated with BBB dysfunction in MOG-Ab–associated disorder. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - November 1, 2021 Category: Neurology Authors: Shimizu, F., Ogawa, R., Mizukami, Y., Watanabe, K., Hara, K., Kadono, C., Takahashi, T., Misu, T., Takeshita, Y., Sano, Y., Fujisawa, M., Maeda, T., Nakashima, I., Fujihara, K., Kanda, T. Tags: Autoimmune diseases, All Demyelinating disease (CNS) Article Source Type: research

Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G in the CSF: Clinical Implication of Testing and Association With Disability
This study provides Class II evidence that the presence of CSF MOG-IgG can improve the diagnosis of MOGAD in the absence of an MS phenotype, and intrathecal synthesis of MOG-IgG was associated with increased disability. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - October 28, 2021 Category: Neurology Authors: Kwon, Y. N., Kim, B., Kim, J.-S., Mo, H., Choi, K., Oh, S.-i., Kim, J.-E., Nam, T.-S., Sohn, E. H., Heo, S. H., Kim, S. B., Park, K.-C., Yoon, S. S., Oh, J., Baek, S.-H., Kim, B.-J., Park, K. S., Sung, J.-J., Jung, J. H., Kim, S.-J., Park, S.-H., Waters, Tags: Class II, All Demyelinating disease (CNS) Article Source Type: research