Long-term Follow-up and Muscle Imaging Findings in Brachio-Cervical Inflammatory Myopathy
Conclusion BCIM is an inflammatory myopathy with a peculiar clinical and radiologic presentation and a relatively broad spectrum of severity. Long-term follow-up data suggest that appropriate and early treatment can prevent chronic muscle function impairment. MRI characterization can be helpful in reducing diagnostic and treatment delay with positive consequence on clinical outcome. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 19, 2021 Category: Neurology Authors: Lucchini, M., Bortolani, S., Monforte, M., Papacci, M., Ricci, E., Mirabella, M., Tasca, G. Tags: MRI, Autoimmune diseases, Muscle disease, EMG Article Source Type: research

Updated Diagnostic Criteria for Paraneoplastic Neurologic Syndromes
Conclusions The proposed criteria and recommendations should be used to enhance the clinical care of patients with PNS and to encourage standardization of research initiatives addressing PNS. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 18, 2021 Category: Neurology Authors: Graus, F., Vogrig, A., Muniz-Castrillo, S., Antoine, J.-C. G., Desestret, V., Dubey, D., Giometto, B., Irani, S. R., Joubert, B., Leypoldt, F., McKeon, A., Prüss, H., Psimaras, D., Thomas, L., Titulaer, M. J., Vedeler, C. A., Verschuuren, J. J., D Tags: Autoimmune diseases, Encephalitis, Peripheral neuropathy, All Oncology, Paraneoplastic syndrome Article Source Type: research

Exosomes From Subjects With Multiple Sclerosis Express EBV-Derived Proteins and Activate Monocyte-Derived Macrophages
Conclusion Exosomes expressing EBV proteins correlate with disease activity and induce an inflammatory response in MDMs that is compounded by the origin of the responder cells. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 18, 2021 Category: Neurology Authors: Mrad, M. F., Saba, E. S., Nakib, L., Khoury, S. J. Tags: Multiple sclerosis Article Source Type: research

Allogeneic BK Virus-Specific T-Cell Treatment in 2 Patients With Progressive Multifocal Leukoencephalopathy
Conclusions We demonstrate that this optimized allogeneic BKV-CTL treatment paradigm represents a promising, innovative therapeutic option for PML and should be investigated in larger, controlled clinical trials. Classification of Evidence This study provides Class IV evidence that for patients with PML, allogeneic transplant of BKV-CTL improved symptoms, reduced MRI changes, and decreased viral load. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 17, 2021 Category: Neurology Authors: Hopfner, F., Möhn, N., Eiz-Vesper, B., Maecker-Kolhoff, B., Gottlieb, J., Blasczyk, R., Mahmoudi, N., Pars, K., Adams, O., Stangel, M., Wattjes, M. P., Höglinger, G., Skripuletz, T. Tags: All Imaging, All Immunology, Autoimmune diseases, Viral infections, Class IV Article Source Type: research

Can Systemic Anti-CD20 B Cell-Depleting Antibodies Eliminate Meningeal Follicles in Multiple Sclerosis?
(Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 17, 2021 Category: Neurology Authors: Gupta, S., Zamvil, S. S. Tags: All Demyelinating disease (CNS), Multiple sclerosis Editorial Source Type: research

The Pursuit of Precision in Paraneoplastic Neurologic Disease
(Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 13, 2021 Category: Neurology Authors: Abbatemarco, J. R., Clardy, S. L. Tags: All Immunology, Autoimmune diseases, Paraneoplastic syndrome Editorial Source Type: research

Delayed Benefit From Aggressive Immunotherapy in Waxing and Waning Anti-IgLON5 Disease
(Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 13, 2021 Category: Neurology Authors: Shambrook, P., Hesters, A., Marois, C., Zemba, D., Servan, J., Gaymard, B., Pico, F., Delorme, C., Lubetzki, C., Arnulf, I., Psimaras, D., Honnorat, J., Gales, A., Meneret, A. Tags: Autoimmune diseases, Encephalitis, All Movement Disorders, All Sleep Disorders Clinical/Scientific Notes Source Type: research

Anti-Adenylate Kinase 5 Encephalitis With Histologic Evidence of CNS Vasculitis
(Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 11, 2021 Category: Neurology Authors: Vicino, A., Loser, V., Salvioni Chiabotti, P., Brouland, J. P., Du Pasquier, R. Tags: Autoimmune diseases, Vasculitis, All Clinical Neurology Clinical/Scientific Notes Source Type: research

Perturbed Microbiota/Immune Homeostasis in Multiple Sclerosis
Conclusions Gut and systemic microbiota/immune homeostasis are perturbed in MS. Our results argue that defective IgA responses in MS are linked to a breakdown of systemic tolerance to gut microbiota leading to an enhanced triggering of systemic IgG immunity against gut commensals occurring early in MS. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 11, 2021 Category: Neurology Authors: Sterlin, D., Larsen, M., Fadlallah, J., Parizot, C., Vignes, M., Autaa, G., Dorgham, K., Juste, C., Lepage, P., Aboab, J., Vicart, S., Maillart, E., Gout, O., Lubetzki, C., Deschamps, R., Papeix, C., Gorochov, G. Tags: All Immunology, Autoimmune diseases, Multiple sclerosis Article Source Type: research

Neurology Neuroimmunology & Neuroinflammation's Acknowledgment to Reviewers
(Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 4, 2021 Category: Neurology Tags: Acknowledgment to Reviewers Source Type: research

Tissue Transglutaminase Expression Associates With Progression of Multiple Sclerosis
Conclusion PBMC-derived TG2 mRNA levels hold promise as biomarker for disease progression in patients with MS. Classification of Evidence This study provides Class II evidence that in patients with MS, PBMC-derived TG2 mRNA levels are associated with disease progression. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - April 27, 2021 Category: Neurology Authors: Sestito, C., Leurs, C. E., Steenwijk, M. D., Breve, J. J. P., Twisk, J. W. R., Wilhelmus, M. M. M., Drukarch, B., Teunissen, C. E., van Dam, A.-M., Killestein, J. Tags: MRI, Autoimmune diseases, Class II, Multiple sclerosis Article Source Type: research

Serum Neurofilament Levels and PML Risk in Patients With Multiple Sclerosis Treated With Natalizumab
Conclusions These results support the use of serum NFL levels in clinical practice to identify patients with relapsing-remitting MS at higher PML risk and to differentiate PML from clinical relapses in NTZ-treated patients. Classification of Evidence This study provides Class I evidence that serum NFL levels can identify NTZ-treated patients with MS who will develop PML with a sensitivity of 67% and specificity of 80%. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - April 26, 2021 Category: Neurology Authors: Fissolo, N., Pignolet, B., Rio, J., Vermersch, P., Ruet, A., deSeze, J., Labauge, P., Vukusic, S., Papeix, C., Martinez-Almoyna, L., Tourbah, A., Clavelou, P., Moreau, T., Pelletier, J., Lebrun-Frenay, C., Bourre, B., Defer, G., Montalban, X., Brassat, D. Tags: Class I, Multiple sclerosis Article Source Type: research

Pain, Depression, and Quality of Life in Neuromyelitis Optica Spectrum Disorder: A Cross-Sectional Study of 166 AQP4 Antibody-Seropositive Patients
Conclusions Myelitis episodes involving upper thoracic segments are main drivers of pain in NMOSD. Although pain intensity was lower than in previous studies, pain and depression remain undertreated and strongly affect QoL. Interventional studies on targeted treatment strategies for pain are urgently needed in NMOSD. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - April 20, 2021 Category: Neurology Authors: Ayzenberg, I., Richter, D., Henke, E., Asseyer, S., Paul, F., Trebst, C., Hümmert, M. W., Havla, J., Kümpfel, T., Ringelstein, M., Aktas, O., Wildemann, B., Jarius, S., Häussler, V., Stellmann, J.-P., Senel, M., Klotz, L., Pellkofe Tags: All Clinical Neurology, All Pain, Central pain, Neuropathic pain, Devic's syndrome Article Source Type: research

Discontinuation of Immunosuppressive Therapy in Patients With Neuromyelitis Optica Spectrum Disorder With Aquaporin-4 Antibodies
(Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - April 19, 2021 Category: Neurology Tags: Correction Source Type: research

Demyelinating Events Following Initiation of Anti-TNF{alpha} Therapy in the British Society for Rheumatology Biologics Registry in Rheumatoid Arthritis
Conclusions Demyelination following anti-TNF therapy is uncommon. Patients receiving anti-TNFα therapy show a marginally increased SIR; this is lost in sensitivity analyses. Patients concerned about anti–TNFα-associated demyelination can be relatively reassured by these data. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - April 16, 2021 Category: Neurology Authors: Taylor, T. R. P., Galloway, J., Davies, R., Hyrich, K., Dobson, R. Tags: Autoimmune diseases, All Medical/Systemic disease, All Demyelinating disease (CNS) Article Source Type: research