Antiplexin D1 Antibodies Relate to Small Fiber Neuropathy and Induce Neuropathic Pain in Animals
Conclusions Plexin D1-IgG is pathogenic but with low prevalence and is a potential biomarker for immunotherapy in SFN. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - June 7, 2021 Category: Neurology Authors: Fujii, T., Lee, E.-J., Miyachi, Y., Yamasaki, R., Lim, Y.-M., Iinuma, K., Sakoda, A., Kim, K.-K., Kira, J.-i. Tags: Autoimmune diseases, Peripheral neuropathy, Neuropathic pain Article Source Type: research

Nodular Pachymeningitis Associated With Relapsing Polychondritis and Crohn Disease Responsive to Adalimumab and Prednisone
Conclusions Although exceptionally rare, pachymeningitis may occur as a neuroinflammatory complication of CD and RP. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - June 2, 2021 Category: Neurology Authors: Hutto, S. K., Maher, M. D., Miloslavsky, E. M., Venna, N. Tags: Article Source Type: research

Aggressive Herpes Zoster in Young Patients With Multiple Sclerosis Under Dimethyl Fumarate: Significance of CD8+ and Natural Killer Cells
(Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 28, 2021 Category: Neurology Authors: Anagnostouli, M. C., Velonakis, G., Dalakas, M. C. Tags: Multiple sclerosis Clinical/Scientific Notes Source Type: research

Gene-Environment Interactions in Multiple Sclerosis: A UK Biobank Study
Conclusions This study provides novel evidence for an interaction between childhood obesity and a high burden of autosomal genetic risk. These findings may have significant implications for our understanding of MS biology and inform targeted prevention strategies. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 28, 2021 Category: Neurology Authors: Jacobs, B. M., Noyce, A. J., Bestwick, J., Belete, D., Giovannoni, G., Dobson, R. Tags: Multiple sclerosis, All Genetics Article Source Type: research

Kappa-Free Light Chains in CSF Predict Early Multiple Sclerosis Disease Activity
Conclusion High -FLC index predicts early MS disease activity. Classification of Evidence This study provides Class II evidence that in patients with early MS, high -FLC index is an independent risk factor for early second clinical attack. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 28, 2021 Category: Neurology Authors: Berek, K., Bsteh, G., Auer, M., Di Pauli, F., Grams, A., Milosavljevic, D., Poskaite, P., Schnabl, C., Wurth, S., Zinganell, A., Berger, T., Walde, J., Deisenhammer, F., Hegen, H. Tags: Cerebrospinal Fluid, Class II, Multiple sclerosis Article Source Type: research

Association of Retinal Layer Thickness With Cognition in Patients With Multiple Sclerosis
Conclusion In patients with MS, at less advanced disease stages, RLT was especially associated with cognitive flexibility promoting OCT as a potential marker advocating further extensive neuropsychological examination. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 27, 2021 Category: Neurology Authors: Baetge, S. J., Dietrich, M., Filser, M., Renner, A., Stute, N., Gasis, M., Weise, M., Lepka, K., Graf, J., Goebels, N., Hartung, H.-P., Aktas, O., Meuth, S., Albrecht, P., Penner, I.-K. Tags: Neuropsychological assessment, Multiple sclerosis Article Source Type: research

Inhibition of Maternal-to-Fetal Transfer of IgG Antibodies by FcRn Blockade in a Mouse Model of Arthrogryposis Multiplex Congenita
Conclusions FcRn blockade is a promising therapeutic strategy to prevent the occurrence of AMC and other human maternal autoantibody-related diseases in the offspring. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 27, 2021 Category: Neurology Authors: Coutinho, E., Jacobson, L., Shock, A., Smith, B., Vernon, A., Vincent, A. Tags: Autoimmune diseases, Myasthenia, Developmental disorders Article Source Type: research

Single-Dose Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy
(Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 26, 2021 Category: Neurology Authors: Beudel, M., Rövekamp, F., van de Beek, D., Brouwer, M. Tags: Autoimmune diseases, All Infections, Viral infections, Class IV Clinical/Scientific Notes Source Type: research

Systemic Inflammation Is Associated With Neurologic Involvement in Pediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2
(Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 21, 2021 Category: Neurology Tags: Correction Source Type: research

Anti-CD20 Depletes Meningeal B Cells but Does Not Halt the Formation of Meningeal Ectopic Lymphoid Tissue
Conclusions These results demonstrate that, in CNS autoimmune disease, meningeal inflammatory infiltrates may form and persist in the absence of B cells. Together with the finding that aCD20 mAb does not ameliorate spontaneous chronic EAE with mELT, our data suggest that mELT may have yet unknown capacities that are independent of B cells and contribute to CNS autoimmunity. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 21, 2021 Category: Neurology Authors: Brand, R. M., Friedrich, V., Diddens, J., Pfaller, M., Romana de Franchis, F., Radbruch, H., Hemmer, B., Steiger, K., Lehmann-Horn, K. Tags: Multiple sclerosis Article Source Type: research

Use of Disease-Modifying Therapies in Pediatric Relapsing-Remitting Multiple Sclerosis in the United Kingdom
Conclusion Newer DMTs were associated with a lower risk of clinical and radiologic relapses in patients compared with injectables. Our study adds weight to the argument for an imminent shift in practice toward the use of newer, more efficacious DMTs in the first instance. Classification of Evidence This study provides Class IV evidence that newer DMTs (oral or infusions) are superior to injectables (interferon beta/glatiramer acetate) in reducing both clinical relapses and radiologic activity in children with RRMS. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 21, 2021 Category: Neurology Authors: Abdel-mannan, O. A., Manchoon, C., Rossor, T., Southin, J.-C., Tur, C., Brownlee, W., Byrne, S., Chitre, M., Coles, A., Forsyth, R., Kneen, R., Mankad, K., Ram, D., West, S., Wright, S., Wassmer, E., Lim, M., Ciccarelli, O., Hemingway, C., Hacohen, Y., on Tags: MRI, All Pediatric, Class IV, Multiple sclerosis Article Source Type: research

Network Damage Predicts Clinical Worsening in Multiple Sclerosis: A 6.4-Year Study
Conclusions Integration of MRI network measures helped determining the relative contributions of global/local GM damage and functional reorganization to clinical deterioration in MS. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 21, 2021 Category: Neurology Authors: Rocca, M. A., Valsasina, P., Meani, A., Pagani, E., Cordani, C., Cervellin, C., Filippi, M. Tags: fMRI, Volumetric MRI, Prognosis, Multiple sclerosis Article Source Type: research

Autoimmune Global Amnesia as Manifestation of AMPAR Encephalitis and Neuropathologic Findings
Conclusion AMPAR antibodies usually associate with limbic encephalitis but may also present with immune responsive, acute-to-subacute, isolated hippocampal dysfunction without overt inflammatory CSF or MRI changes. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 20, 2021 Category: Neurology Authors: Ricken, G., Zrzavy, T., Macher, S., Altmann, P., Troger, J., Falk, K. K., Kiefer, A., Fichtenbaum, A., Mitulovic, G., Kubista, H., Wandinger, K.-P., Rommer, P., Bartsch, T., Berger, T., Weber, J., Leypoldt, F., Höftberger, R. Tags: Autoimmune diseases, Memory Article Source Type: research

COVID-19 Among Patients With Multiple Sclerosis: A Systematic Review
Conclusion Our study suggested that MS did not significantly increase the mortality rate from COVID-19. These data should be interpreted with caution as patients with MS are more likely female and younger compared with the general population where age and male sex seem to be risk factors for worse disease outcome. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 20, 2021 Category: Neurology Authors: Barzegar, M., Mirmosayyeb, O., Gajarzadeh, M., Afshari-Safavi, A., Nehzat, N., Vaheb, S., Shaygannejad, V., Maghzi, A.-H. Tags: COVID-19, Multiple sclerosis Views [amp ] Reviews Source Type: research

Long-term Follow-up and Muscle Imaging Findings in Brachio-Cervical Inflammatory Myopathy
Conclusion BCIM is an inflammatory myopathy with a peculiar clinical and radiologic presentation and a relatively broad spectrum of severity. Long-term follow-up data suggest that appropriate and early treatment can prevent chronic muscle function impairment. MRI characterization can be helpful in reducing diagnostic and treatment delay with positive consequence on clinical outcome. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - May 19, 2021 Category: Neurology Authors: Lucchini, M., Bortolani, S., Monforte, M., Papacci, M., Ricci, E., Mirabella, M., Tasca, G. Tags: MRI, Autoimmune diseases, Muscle disease, EMG Article Source Type: research