Neurology Neuroimmunology and Neuroinflammation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Blocking Placental Class G Immunoglobulin Transfer Prevents NMDA Receptor Antibody Effects in Newborn Mice
Discussion FcRn blockade prevents placental transfer of IgG from patients with anti-NMDAR encephalitis and abrogates the synaptic and neurodevelopmental alterations caused by patients' antibodies. This model has potential therapeutic implications for other antibody-mediated diseases of the CNS during pregnancy. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - September 27, 2021 Category: Neurology Authors: Garcia-Serra, A., Radosevic, M., Rios, J., Aguilar, E., Maudes, E., Landa, J., Sabater, L., Martinez-Hernandez, E., Planaguma, J., Dalmau, J. Tags: Autoimmune diseases, Neonatal Article Source Type: research

Intrathymic Plasmablasts Are Affected in Patients With Myasthenia Gravis With Active Disease
Discussion Our findings confirmed a correlation between increased frequency of intrathymic plasmablasts and disease activity before thymectomy. We postulate that activated intrathymic plasmablasts endow pathogenic capacity in MG. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - September 24, 2021 Category: Neurology Authors: Yamamoto, Y., Matsui, N., Uzawa, A., Ozawa, Y., Kanai, T., Oda, F., Kondo, H., Ohigashi, I., Takizawa, H., Kondo, K., Sugano, M., Kitaichi, T., Hata, H., Kaji, R., Kuwabara, S., Yamamura, T., Izumi, Y. Tags: All Immunology, Autoimmune diseases, All Neuromuscular Disease, Myasthenia Article Source Type: research

T-Cell Specificity Influences Disease Heterogeneity in Multiple Sclerosis
Discussion Our observations reveal an association between autoantigen reactivity and features of disease heterogeneity that strongly supports an important role of T-cell specificity in MS pathogenesis. These data have the potential to improve patient classification in clinical practice and to guide the development of antigen-specific tolerization strategies. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - September 17, 2021 Category: Neurology Authors: Cruciani, C., Puthenparampil, M., Tomas-Ojer, P., Jelcic, I., Docampo, M. J., Planas, R., Manogaran, P., Opfer, R., Wicki, C., Reindl, M., Jelcic, I., Lutterotti, A., Martin, R., Sospedra, M. Tags: All Immunology, Autoimmune diseases, Multiple sclerosis Article Source Type: research

Retinal Optical Coherence Tomography in Neuromyelitis Optica
Discussion Our results emphasize that attack prevention is key to avoid severe neuroaxonal damage and vision loss caused by ON in NMOSD. Therapies ameliorating attack-related damage, especially during a first attack, are an unmet clinical need. Mild signs of neuroaxonal changes without apparent vision loss in ON-unaffected eyes might be solely due to contralateral ON attacks and do not suggest clinically relevant progression but need further investigation. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - September 15, 2021 Category: Neurology Authors: Oertel, F. C., Specovius, S., Zimmermann, H. G., Chien, C., Motamedi, S., Bereuter, C., Cook, L., Lana Peixoto, M. A., Fontanelle, M. A., Kim, H. J., Hyun, J.-W., Palace, J., Roca-Fernandez, A., Leite, M. I., Sharma, S., Ashtari, F., Kafieh, R., Dehghani, Tags: All Imaging, Retina, Visual loss, Devic's syndrome, Optic neuritis; see Neuro-ophthalmology/Optic Nerve Article Source Type: research

CSF Chitinase 3-Like 2 Is Associated With Long-term Disability Progression in Patients With Progressive Multiple Sclerosis
Conclusions Although further confirmatory studies are needed, we propose CSF CHI3L2 as a prognostic protein biomarker associated with long-term disability progression in patients with progressive MS. Classification of Evidence This study provides Class II evidence that high CSF CHI3L2 levels identified higher disability progression in patients with progressive MS. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - September 8, 2021 Category: Neurology Authors: Comabella, M., Sastre-Garriga, J., Borras, E., Villar, L. M., Saiz, A., Martinez-Yelamos, S., Garcia-Merino, J. A., Pinteac, R., Fissolo, N., Sanchez Lopez, A. J., Costa-Frossard, L., Blanco, Y., Llufriu, S., Vidal-Jordana, A., Sabido, E., Montalban, X. Tags: Class II, Multiple sclerosis Article Source Type: research