T-Cell Specificity Influences Disease Heterogeneity in Multiple Sclerosis

Discussion
Our observations reveal an association between autoantigen reactivity and features of disease heterogeneity that strongly supports an important role of T-cell specificity in MS pathogenesis. These data have the potential to improve patient classification in clinical practice and to guide the development of antigen-specific tolerization strategies.

Source: Neurology Neuroimmunology and Neuroinflammation - September 17, 2021 Category: Neurology Authors: Cruciani, C., Puthenparampil, M., Tomas-Ojer, P., Jelcic, I., Docampo, M. J., Planas, R., Manogaran, P., Opfer, R., Wicki, C., Reindl, M., Jelcic, I., Lutterotti, A., Martin, R., Sospedra, M. Tags: All Immunology, Autoimmune diseases, Multiple sclerosis Article Source Type: research