Neurology Neuroimmunology and Neuroinflammation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Slowly Expanding Lesions Predict 9-Year Multiple Sclerosis Disease Progression
This study provides Class III evidence that in patients with RRMS starting treatment with natalizumab or fingolimod, the proportion of SELs on brain MRI was associated with EDSS score worsening and SPMS conversion at 9-year follow-up. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - February 1, 2022 Category: Neurology Authors: Preziosa, P., Pagani, E., Meani, A., Moiola, L., Rodegher, M., Filippi, M., Rocca, M. A. Tags: MRI, Class III, Multiple sclerosis Article Source Type: research

Cortical and Subcortical Dysmetabolism Are Dynamic Markers of Clinical Disability and Course in Anti-LGI1 Encephalitis
This study provides Class II evidence that semiquantitative measures of putaminal metabolism on PET can differentiate patients with LGI1-AE from patients without LGI1-AE, patients with AD, or NCs. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - January 28, 2022 Category: Neurology Authors: Rissanen, E., Carter, K., Cicero, S., Ficke, J., Kijewski, M., Park, M.-A., Kijewski, J., Stern, E., Chitnis, T., Silbersweig, D., Weiner, H. L., Kim, C. K., Lyons, J., Klein, J. P., Bhattacharyya, S., Singhal, T. Tags: PET, Class III Article Source Type: research

Optic Nerve Lesion Length at the Acute Phase of Optic Neuritis Is Predictive of Retinal Neuronal Loss
This study provides Class I evidence that optic nerve lesion length measured on MRI during the acute phase of a first episode of ON is associated with long-term retinal neuro-axonal loss and visual impairment. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - January 28, 2022 Category: Neurology Authors: Denis, M., Woillez, J.-P., Smirnov, V. M., Drumez, E., Lannoy, J., Boucher, J., Zedet, M., Pruvo, J.-P., Labreuche, J., Zephir, H., Leclerc, X., Outteryck, O. Tags: MRI, Optic nerve, Retina, Class I, Optic neuritis; see Neuro-ophthalmology/Optic Nerve Article Source Type: research

Progranulin Suppressed Autoimmune Uveitis and Autoimmune Neuroinflammation by Inhibiting Th1/Th17 Cells and Promoting Treg Cells and M2 Macrophages
The objective of this study is to investigate the role of PGRN in uveitis and its counterpart, experimental autoimmune uveitis (EAU), and experimental autoimmune encephalomyelitis (EAE). Methods Serum PGRN levels in patients with Behcet disease (BD) or Vogt-Koyanagi-Harada (VKH) disease and normal controls were measured by ELISA. EAE and EAU were induced in B10RIII, wild-type, and PGRN–/– mice to evaluate the effect of PGRN on the development of these 2 immune-mediated disease models. The local and systemic immunologic alterations were detected by ELISA, flow cytometry, and real-time PCR. RNA sequencing was pe...
Source: Neurology Neuroimmunology and Neuroinflammation - January 26, 2022 Category: Neurology Authors: Wang, C., Zhou, W., Su, G., Hu, J., Yang, P. Tags: All Immunology, Autoimmune diseases, All Medical/Systemic disease, All Demyelinating disease (CNS) Article Source Type: research

Risk of Getting COVID-19 in People With Multiple Sclerosis: A Case-Control Study
This study provides Class III evidence that among patients with MS, younger age, being female individuals, having more comorbidities, receiving natalizumab, undergoing an escalating treatment strategy, or receiving treatment at a hospital were associated with being infected with COVID-19. Among patients with MS who were infected with COVID-19, a severe course was associated with increasing age and having a progressive form of MS, whereas not being on treatment or receiving an interferon beta agent was protective. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - January 19, 2022 Category: Neurology Authors: Iaffaldano, P., Lucisano, G., Manni, A., Paolicelli, D., Patti, F., Capobianco, M., Brescia Morra, V., Sola, P., Pesci, I., Lus, G., De Luca, G., Lugaresi, A., Cavalla, P., Montepietra, S., Maniscalco, G. T., Granella, F., Ragonese, P., Vianello, M., Bram Tags: Class III, COVID-19, Multiple sclerosis, Case control studies Article Source Type: research

Dimethyl Fumarate Reduces Inflammation in Chronic Active Multiple Sclerosis Lesions
This study provided Class III evidence that DMF is superior to GA in the presence of iron as a marker of inflammation as measured by MRI quantitative susceptibility mapping. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - January 19, 2022 Category: Neurology Authors: Zinger, N., Ponath, G., Sweeney, E., Nguyen, T. D., Lo, C. H., Diaz, I., Dimov, A., Teng, L., Zexter, L., Comunale, J., Wang, Y., Pitt, D., Gauthier, S. A. Tags: MRI, All Immunology, Multiple sclerosis Article Source Type: research

SEZ6L2 Antibody-Associated Cerebellar Ataxia Responsive to Sequential Immunotherapy
We present a case report of a 73-year-old woman with progressive balance problems. Her condition had rapidly deteriorated in the 2 weeks before the admission to our hospital leading to repeated falls and eventually left her bed-ridden. Results She presented with severe trunk ataxia, bidirectional nystagmus, dysarthric speech, and persistent nausea. With the exception of cerebellar atrophy, extensive imaging studies revealed no pathology. SEZ6L2 antibodies were found in both CSF and serum. Over a period of 9 months, our patient received immunotherapy consisting of steroid pulse therapy, IV immunoglobulin infusions, rituxim...
Source: Neurology Neuroimmunology and Neuroinflammation - January 14, 2022 Category: Neurology Authors: Mehdiyeva, A., Hietaharju, A., Sipilä, J. Tags: All Immunology, Autoimmune diseases, Encephalitis, Gait disorders/ataxia, Class IV Clinical/Scientific Note Source Type: research

Assessing Neurofilaments as Biomarkers of Neuroprotection in Progressive Multiple Sclerosis: From the MS-STAT Randomized Controlled Trial
This study provides class I evidence that simvastatin treatment does not have a large impact on either serum NfL or NfH, as quantified in this study, in SPMS. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - January 14, 2022 Category: Neurology Authors: Williams, T. E., Holdsworth, K. P., Nicholas, J. M., Eshaghi, A., Katsanouli, T., Wellington, H., Heslegrave, A., Zetterberg, H., Frost, C., Chataway, J. Tags: Clinical trials Randomized controlled (CONSORT agreement), Class I, Multiple sclerosis Article Source Type: research

Increased Intrathecal B and Plasma Cells in Patients With Anti-IgLON5 Disease: A Case Series
Discussion Our findings indicate the importance of inflammatory mechanisms, in particular in early and acute anti-IgLON5 cases, which may support the use of immune-suppressive treatments in these cases. The main limitation of the study is the small number of cases due to the rarity of the disease. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - January 14, 2022 Category: Neurology Authors: Strippel, C., Heidbreder, A., Schulte-Mecklenbeck, A., Korn, L., Warnecke, T., Melzer, N., Wiendl, H., Pawlowski, M., Gross, C. C., Kovac, S. Tags: All Immunology, Autoimmune diseases Clinical/Scientific Note Source Type: research

Antineonatal Fc Receptor Antibody Treatment Ameliorates MOG-IgG-Associated Experimental Autoimmune Encephalomyelitis
Discussion We show preserved optomotor response and ameliorated course of disease after anti-FcRn treatment in an experimental model using a monoclonal MOG-IgG to mimic MOGAD. Selectively targeting FcRn might represent a promising therapeutic approach in MOGAD. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - January 13, 2022 Category: Neurology Authors: Remlinger, J., Madarasz, A., Guse, K., Hoepner, R., Bagnoud, M., Meli, I., Feil, M., Abegg, M., Linington, C., Shock, A., Boroojerdi, B., Kiessling, P., Smith, B., Enzmann, V., Chan, A., Salmen, A. Tags: Optic nerve, Retina Article Source Type: research

Central Vein Sign Profile of Newly Developing Lesions in Multiple Sclerosis: A 3-Year Longitudinal Study
This study provides Class III evidence that younger age and higher CVS+ percentage at baseline are associated with new CVS+ lesion development. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - January 13, 2022 Category: Neurology Authors: Al-Louzi, O., Letchuman, V., Manukyan, S., Beck, E. S., Roy, S., Ohayon, J., Pham, D. L., Cortese, I., Sati, P., Reich, D. S. Tags: MRI, Class III, Multiple sclerosis Article Source Type: research

Leveraging Visual Outcome Measures to Advance Therapy Development in Neuroimmunologic Disorders
The visual system offers unparalleled precision in the assessment of neuroaxonal damage. With the majority of patients with multiple sclerosis (MS) experiencing afferent and efferent visual dysfunction, outcome measures capturing these deficits provide insight into neuroaxonal injury, even in those with minimal disability. Ideal for use in clinical trials, visual measures are generally inexpensive, accessible, and reproducible. Quantification of visual acuity, visual fields, visual quality of life, and electrophysiologic parameters allows assessment of function, whereas optical coherence tomography (OCT) provides reliable ...
Source: Neurology Neuroimmunology and Neuroinflammation - December 26, 2021 Category: Neurology Authors: Graves, J. S., Oertel, F. C., Van der Walt, A., Collorone, S., Sotirchos, E. S., Pihl-Jensen, G., Albrecht, P., Yeh, E. A., Saidha, S., Frederiksen, J., Newsome, S. D., Paul, F., on behalf of IMSVISUAL, on behalf of IMSVISUAL Tags: MRI, All Neuro-ophthalmology, Multiple sclerosis, Devic's syndrome Views [amp ] Reviews Source Type: research

Abnormal B-Cell and Tfh-Cell Profiles in Patients With Parkinson Disease: A Cross-sectional Study
Discussion Our findings define a novel signature of peripheral immune cells and implicate aberrant Tfh:B-cell interactions in patients with PD. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - December 26, 2021 Category: Neurology Authors: Li, R., Tropea, T. F., Baratta, L. R., Zuroff, L., Diaz-Ortiz, M. E., Zhang, B., Shinoda, K., Rezk, A., Alcalay, R. N., Chen-Plotkin, A., Bar-Or, A. Tags: All Immunology, Parkinson's disease/Parkinsonism Article Source Type: research

Retinal Optical Coherence Tomography in Neuromyelitis Optica
(Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - December 22, 2021 Category: Neurology Tags: CORRECTION Source Type: research

Isolated Memory Loss in Anti-NMDAR Encephalitis
Discussion This case shows that anti-NMDAR encephalitis can present with isolated memory loss. Neural antibody testing in these patients could play a pivotal role in early diagnosis and prompt treatment. (Source: Neurology Neuroimmunology and Neuroinflammation)
Source: Neurology Neuroimmunology and Neuroinflammation - December 22, 2021 Category: Neurology Authors: Iorio, R., Sabatelli, E., Campetella, L., Papi, C. Tags: Autoimmune diseases Clinical/Scientific Note Source Type: research