Anti-C2 Antibody ARGX-117 Inhibits Complement in a Disease Model for Multifocal Motor Neuropathy

Discussion Binding of IgM antibodies from patients with MMN to iPSC-derived MNs induces complement activation. By expressing complement regulatory proteins, particularly CD59, MNs are protected against complement-mediated lysis. Yet, because of expressing C3aR, the function of these cells may be affected by complement activation upstream of membrane attack complex formation. ARGX-117 inhibits complement activation upstream of C3 in this disease model for MMN and therefore represents an intervention strategy to prevent harmful effects of complement in MMN.

http://nn.neurology.org/cgi/content/short/9/1/e1107?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - November 10, 2021 Category: Neurology Authors: Budding, K., Johansen, L. E., Van de Walle, I., Dijkxhoorn, K., de Zeeuw, E., Bloemenkamp, L. M., Bos, J. W., Jansen, M. D., Curial, C. A. D., Silence, K., de Haard, H., Blanchetot, C., Van de Ven, L., Leusen, J. H. W., Pasterkamp, R. J., van den Berg, L. Tags: All Immunology, All Neuromuscular Disease Article Source Type: research