B Cells in the CNS at Postmortem Are Associated With Worse Outcome and Cell Types in Multiple Sclerosis

Discussion
Perivascular B cells were associated with worse clinical outcomes and CNS-compartmentalized inflammation. Our findings further support the concept of targeting compartmentalized B-cell inflammation in progressive MS.

Source: Neurology Neuroimmunology and Neuroinflammation - November 10, 2021 Category: Neurology Authors: Moccia, M., Haider, L., Eshaghi, A., van de Pavert, S. H. P., Brescia Morra, V., Patel, A., Wheeler-Kingshott, C. A. M., Barkhof, F., Ciccarelli, O. Tags: Multiple sclerosis Article Source Type: research