Erratum
Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 9, 2020 Category: Endocrinology Source Type: research
GLP-1 regulates the POMC neurons of the arcuate nucleus both directly and indirectly via presynaptic action
GLP-1 exerts its anorexigenic effect at least partly via the POMC neurons of the arcuate nucleus (ARC). These neurons are known to express GLP-1 receptor (GLP-1R).
To determine whether in addition to its direct effect, GLP-1 also modulates, how neuronal inputs can regulate the POMC neurons by acting on presynaptic terminals, ultrastructural and electrophysiological studies were performed on tissues of adult male mice.
GLP-1R-immunoreactivity was associated with the cell membrane of POMC neurons and with axon terminals forming synapses on these cells. The GLP-1 analog Exendin 4 (Ex4) markedly increased the firing rate of ...
Source: Neuroendocrinology - November 4, 2020 Category: Endocrinology Source Type: research
Cortisol circadian rhythm and insulin resistance in muscle: effect of dosing and timing of hydrocortisone exposure on insulin sensitivity in synchronized muscle cells.
Conclusions: The current study demonstrated that is late-in-the-day cortisol exposure that modulates insulin sensitivity-related genes expression and intracellular insulin signaling in skeletal muscle cells. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 29, 2020 Category: Endocrinology Source Type: research
Modulation of pancreatic neuroendocrine neoplastic cell fate by autophagy mediated death
Conclusion Our study h ighlights that the autophagy functional restoration and prolongation of this catabolic process, mediated by inhibition of deacetylase, is responsible for the reduction of pNEN cells. Prompting of autophagy cell death could be a promising strategy for the therapy of pNEN. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 26, 2020 Category: Endocrinology Source Type: research
ctDNA in neuroendocrine carcinoma of gastroenteropancreatic origin or of unknown primary: the CIRCAN-NEC pilot study
Conclusion: This pilot study shows a high sensitivity of ctDNA assessment, which is encouraging for the future management of GEPNEC (tumour molecular diagnosis and evaluation of disease progression). (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 22, 2020 Category: Endocrinology Source Type: research
The Protective and Reparative Role of Colony Stimulating Factors in the Brain with Cerebral Ischemia / Reperfusion Injury
Stroke is a debilitating disease and has the ability to culminate in devastating clinical outcomes. Ischemic stroke followed by reperfusion entrains cerebral ischemia / reperfusion (I/R) injury, which is a complex pathological process and is associated with serious clinical manifestations. Therefore, the development of a robust and effective post-stroke therapy is crucial. Granulocyte colony stimulating factor (GCSF) and erythropoietin (EPO), originally discovered as hematopoietic growth factors, are versatile and have transcended beyond their traditional role of orchestrating the proliferation, differentiation and surviva...
Source: Neuroendocrinology - October 18, 2020 Category: Endocrinology Source Type: research
Efficacy of a novel second-generation somatostatin-dopamine chimera (TBR-065) in human medullary thyroid cancer: a preclinical study
Conclusion: In MTC cell lines a second generation somatostatin-dopamine analogue, TBR-065, exerts a more relevant anti-tumor activity, as compared with LAN, through modulation of cell cycle, induction of apoptosis and reduction in migration. Further studies are required to establish whether TBR-065 has comparable potent inhibitory effects on tumor growth in vivo. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 18, 2020 Category: Endocrinology Source Type: research
A Chinese case of X-linked acrogigantism and systemic review
Conclusion: It is important to recognize the possibility of X-LAG when a child under 2 years old presents overgrowth. Early diagnosis and treat ment are of great importance for better treatment efficacy and clinical outcome. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 12, 2020 Category: Endocrinology Source Type: research
Craniopharyngioma in the elderly: a multicenter and nation-wide study in spain
Conclusion. CP diagnosed in the elderly shows a similar distribut ion by sex and histologic forms than that diagnosed at younger ages. At presentation visual field alterations and headaches are the main clinical symptoms which improve substantially with surgery. However, surgery, mainly NTR, is accompanied by worsening of pituitary function, especially DI, which s eems to be a predictor of mortality in this population. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 8, 2020 Category: Endocrinology Source Type: research
Capecitabine-Temozolomide (CAPTEM) in advanced Grade 2 and grade 3 Neuroendocrine neoplasms (NENs) – benefits of chemotherapy in NENs with significant 18FDG uptake
The objective of this study was to evaluate activity of the CAPTEM in patients with grade 2 and grade 3 NENs and identify prognostic factors
Materials and methods
A retrospective analysis of patients with metastatic grade 2 and grade 3 NENs, who were with baseline significant dual uptake on68Ga-DOTATATE/ 18F-FDG-PET-CT scan and treated with CAPTEM chemotherapy between January 2014 and December 2019 at Tata Memorial Hospital was conducted. The clinical variables and survival data were collected. Progression free survival (PFS) was estimated using Kaplan-Meier method.
Results
A total of 68 patients received the CAPTEM re...
Source: Neuroendocrinology - October 4, 2020 Category: Endocrinology Source Type: research
Contents Vol. 110, 2020
Neuroendocrinology 2020;110:I –VI (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 2, 2020 Category: Endocrinology Source Type: research
A consensus developed morphological re-evaluation of 196 high-grade gastroenteropancreatic neuroendocrine neoplasms and its clinical correlations.
High-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) are classified according to morphology as well differentiated neuroendocrine tumours (NET) G3 or poorly differentiated neuroendocrine carcinomas (NEC). Little data exist concerning which morphological criteria this subdivision should be based on. Uncertainty exists if the NEC group should be further subdivided according to proliferation rate. Clinical data on NET G3 and NEC with a lower Ki-67 range are limited.
213 patients with high-grade GEP-NEN (Ki-67>20%) were included from the Nordic NEC Registries. Four experienced NET pathologists re-evaluated the...
Source: Neuroendocrinology - September 30, 2020 Category: Endocrinology Source Type: research
Risk factors for recurrence in pancreatic neuroendocrine tumor and size as a surrogate in determining the treatment strategy: a Korean nationwide study
This study aimed to suggest a treatment algorithm for pancreatic neuroendocrine tumor (PNET) based on risk factors for recurrence in a large cohort.
Methods: Data of 918 patients who underwent curative intent surgery for PNET were collected from 14 tertiary centers. Risk factors for recurrence and survival analyses were performed.
Results: The 5-year disease-free survival (DFS) rate was 86.5%. Risk factors for recurrence included margin status (R1, hazard ratio [HR] 2.438; R2, HR 3.721), 2010 WHO grade (G2, HR 3.864; G3, HR 7.352), and N category (N1, HR 2.273). Size of 2 cm was significant in the univariate analysis (HR...
Source: Neuroendocrinology - September 30, 2020 Category: Endocrinology Source Type: research
Unifocal versus multiple ileal neuroendocrine tumors location: an embryological origin
Introduction: Small-intestinal neuroendocrine tumors (SI-NET) are situated preferentially within the ileum. The aim was to describe a potential difference in location between unifocal and multiple ileal-NET.
Methods: Between December 2010 and December 2019, all consecutive patients who underwent resection in our European Neuroendocrine Tumor Society Center of Excellence, of at least one non-duodenal SI-NET, were retrospectively included. The main objective was to prove that multiple ileal-NET were mostly located on the left side of the superior mesenteric artery (SMA) axis (defined as 40cm from the ileocecal valve), and u...
Source: Neuroendocrinology - September 29, 2020 Category: Endocrinology Source Type: research
A Real-World, Population-Based Study for the Incidence and Outcomes of Neuroendocrine Neoplasms of Unknown Primary
Conclusions:
The diagnosis of NENs of unknown primary has increased across the past four decades. Outcomes of individuals with metastatic small intestinal NENs seem to be better than those with metastatic NENs of unknown primary, both neuroendocrine tumors, and carcinomas. (Source: Neuroendocrinology)
Source: Neuroendocrinology - September 24, 2020 Category: Endocrinology Source Type: research
