Delivery-dependent shift in oxytocin-responsive cell population in the central amygdala of the female rat
Conclusion: These results indicate that the responses of CeA cells to an OT receptor agonist markedly change around delivery, which might play a role in controlling the labor-related pain and post-delivery emotional c omplications. (Source: Neuroendocrinology)
Source: Neuroendocrinology - July 4, 2022 Category: Endocrinology Source Type: research

Progestogen-mediated neuroprotection in central nervous system disorders
Neuroactive steroids can be synthetic or endogenous molecules produced by neuronal and glial cells, and peripheral glands. Examples include estrogens, testosterone, progesterone and its reduced metabolites such as 5 -dihydroprogesterone and allopregnanolone. Steroids produced by neurons and glia target the nervous system and are called neurosteroids. Progesterone and analog molecules, known as progestogens, have been shown to exhibit neurotrophic, neuroprotective, antioxidant, anti-inflammatory, glial modula tory, promyelinating and remyelinating effects in several experimental models of neurodegenerative and injury con...
Source: Neuroendocrinology - June 27, 2022 Category: Endocrinology Source Type: research

Short- and Long-Term Effects of Chlorpyrifos on Thyroid Hormone Axis and Brain Development in < b > < i > Xenopus laevis < /i > < /b >
Conclusion: This study provides more evidence of the endocrine and neurodevelopment disrupting activity of CPF. Further experimental and epidemiological studies are warranted to determine the long-term consequences of early CPF exposure on brain development.Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - June 24, 2022 Category: Endocrinology Source Type: research

Short and long term effects of chlorpyrifos on thyroid hormone axis and brain development in Xenopus laevis
Conclusion This study provides more evidence of the endocrine and neurodevelopment disrupting activity of CPF. Further experimental and epidemiological studies are warranted to determine the long-term consequences of early CPF exposure on brain development. (Source: Neuroendocrinology)
Source: Neuroendocrinology - June 24, 2022 Category: Endocrinology Source Type: research

Prognosis of Patients with Bronchopulmonary Neuroendocrine Neoplasms in a Tertiary Neuroendocrine Tumor Centre of Excellence
Conclusions: Surgical treatment, especially, and diagnosis of TC were associated with a good prognosis. Furthermore, our data did not support routine bronchoscopy as part of a follow-up program for bronchial carcinoids.Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - June 7, 2022 Category: Endocrinology Source Type: research

Prognosis of patients with bronchopulmonary neuroendocrine neoplasms in a tertiary NET Centre of Excellence
Introduction: The European Neuroendocrine Tumor Society, ENETS, reports variables of prognostic significance in bronchopulmonary neuroendocrine neoplasms. The aim of this study was to investigate prognostic factors, recurrence free survival (RFS) and overall survival (OS) for patients with typical carcinoid (TC), atypical carcinoid (AC) and large cell neuroendocrine carcinoma (LCNEC). Current follow-up practices vary as the evidence is sparse and we aimed to explore the relevance of routine bronchoscopy in follow-up. Methods: A cohort study of 208 patients with bronchopulmonary neuroendocrine neoplasms (BP-NENs) followed ...
Source: Neuroendocrinology - June 7, 2022 Category: Endocrinology Source Type: research

Upregulated Angiotensin Ia Receptors in the Hypothalamic Paraventricular Nucleus Sensitize Neuroendocrine Vasopressin Release and Blood Pressure in a Rodent Model of Polycystic Kidney Disease
Conclusion: Collectively, our data suggest that upregulated AT1R expression in PVN sensitizes neuroendocrine release of vasopressin in the LPK, identifying a central mechanism for the elevated vasopressin levels present in PKD. (Source: Neuroendocrinology)
Source: Neuroendocrinology - June 2, 2022 Category: Endocrinology Source Type: research

Upregulated angiotensin ia receptors in the hypothalamic pvn sensitise neuroendocrine vasopressin release and blood pressure in a rodent model of polycystic kidney disease.
Introduction: Angiotensin (Ang) II signalling in the hypothalamic paraventricular nucleus (PVN) via angiotensin type-1a receptors (AT1R) regulates vasopressin release and sympathetic nerve activity - two effectors of blood pressure regulation. We determined the cellular expression and function of AT1R in the PVN of a rodent model of polycystic kidney disease (PKD), the Lewis Polycystic Kidney (LPK) rat, to evaluate its contribution to blood pressure regulation and augmented vasopressin release in PKD. Methods: PVN AT1R gene expression was quantified with fluorescent in-situ hybridisation in LPK and control rats. PVN AT1R ...
Source: Neuroendocrinology - June 2, 2022 Category: Endocrinology Source Type: research

A novel signature based on m6A RNA methylation regulators reveals distinct prognostic subgroups and associates with tumor immunity of patients with pancreatic neuroendocrine neoplasms
Conclusions: YTHDF2 appears to serve as a promising prognostic biomarker and therapeutic target. A YTHDF2-based signature can identify distinct subgroups, which may be helpful to strategize personalized postoperative monitoring. (Source: Neuroendocrinology)
Source: Neuroendocrinology - May 24, 2022 Category: Endocrinology Source Type: research

Treatment Response and Clinical Outcomes of Well-Differentiated High-Grade Neuroendocrine Tumors to Lutetium-177-DOTATATE
Conclusion: We observed a meaningful disease control rate of 72% during treatment of WD HG NETs with177Lu-DOTATATE. In this heavily pre-treated population, more than half of patients received all four treatment cycles with toxicities largely bone marrow-related. As would be expected in WD NETs, the vast majority had alterations in chromatin remodeling genes and no RB1 alterations. (Source: Neuroendocrinology)
Source: Neuroendocrinology - May 24, 2022 Category: Endocrinology Source Type: research

Treatment response and clinical outcomes of well differentiated high grade neuroendocrine tumors to lutetium-177 DOTATATE
Conclusion: We observed a meaningful disease control rate of 72% during treatment of WD HG NETs with 177Lu-DOTATATE. In this heavily pre-treated population, more than half of patients received all four treatment cycles with toxicities largely bone-marrow related. As would be expected in WD NETs, the vast majority had alterations in chromatin remodeling genes and no RB1 alterations. (Source: Neuroendocrinology)
Source: Neuroendocrinology - May 24, 2022 Category: Endocrinology Source Type: research

Streptozotocin, 1982 –2022: Forty Years from the FDA’s Approval to Treat Pancreatic Neuroendocrine Tumors
In May 1982, the US Food and Drug Administration (FDA) approved the use of streptozotocin to treat pancreatic neuroendocrine tumors (panNETs). Thus, this year marks 40 years since that landmark date. This review of streptozotocin to treat panNETs is intended to commemorate this anniversary. A historical perspective of the chemical structure, pharmacokinetics, and mechanism of action of streptozotocin is followed by data from prospective and retrospective clinical studies. The last section of the review addresses the latest aspects and takes note of the prospects that lie ahead on the future horizon of the use of streptozot...
Source: Neuroendocrinology - May 10, 2022 Category: Endocrinology Source Type: research

Streptozotocin. 1982-2022: forty years from the fda ’s approval to treat pancreatic neuroendocrine tumors
On May 1982, the US Food and Drug Administration (FDA) approved the use of streptozotocin to treat pancreatic neuroendocrine tumors (panNETs). Thus, this year marks forty years since that landmark date. This review of streptozotocin to treat panNETs is intended to commemorate this anniversary. A historical perspective of chemical structure, pharmacokinetics, and mechanism of action of streptozotocin is followed by data from prospective and retrospective clinical studies. The last section of the review addresses the latest aspects and takes note of the prospects that lie ahead on the future horizon of the use of stre...
Source: Neuroendocrinology - May 10, 2022 Category: Endocrinology Source Type: research

Genetically determined telomere length is associated with pancreatic neuroendocrine neoplasms onset
Conclusion In conclusion, this study provides for the first time a clear indication of the association between long genetically determined telomeres and increased risk of developing PanNEN. (Source: Neuroendocrinology)
Source: Neuroendocrinology - April 26, 2022 Category: Endocrinology Source Type: research

Could the thyroid gland dominate the brain in obsessive-compulsive disorder?
Thyroid hormones have an essential role in brain maturation and neuronal functioning. The comorbidity of thyroid disorders and several mental disturbances is frequently reported. We aim to evaluate the literature on the potential relationship between thyroid disorders and obsessive-compulsive disorder (OCD), and obsessive-compulsive symptoms (OCS). We searched the literature using PUBMED, ProQuest, Google Scholar, and PsycInfo electronic databases for original studies (cross-sectional, case series, case report) on the association between thyroid dysfunctions and OCD, and OCS between 1977-2021. Eleven studies met the inclus...
Source: Neuroendocrinology - April 20, 2022 Category: Endocrinology Source Type: research