Identifying the Interaction of the Brain and the Pituitary in Social – and Reproductive – State of Tilapia by Transcriptome Analyses
Conclusions: The close correlation between behavioral dominance and reproductive capacity in tilapia allows unraveling novel genes that may regulate the hypothalamic-pituitary-gonadal axis, highlighting aromatase as the main factor affecting the brain and pituitary in maintaining a sexually active organism.Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - April 5, 2022 Category: Endocrinology Source Type: research
Identifying the Interaction of the Brain and the Pituitary in Social- and Reproductive- State of Tilapia by Transcriptome Analyses
Conclusions: the close correlation between behavioral dominance and reproductive capacity in tilapia allows unraveling novel genes that may regulate the HPG axis, highlighting aromatase as the main factor affecting the brain and pituitary in maintaining a sexually active organism. (Source: Neuroendocrinology)
Source: Neuroendocrinology - April 5, 2022 Category: Endocrinology Source Type: research
The Neuroprotective Effect of α-Lipoic Acid and/or Metformin against the Behavioral and Neurochemical Changes Induced by Hypothyroidism in Rat
Conclusion: ALA and/or MET has a potential neuroprotective effect against the adverse behavioral and neurochemical changes induced by hypothyroidism in rats.Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 30, 2022 Category: Endocrinology Source Type: research
The neuroprotective effect of alpha lipoic acid and/or metformin against the behavioral and neurochemical changes induced by hypothyroidism in rat
Conclusion: ALA and/or MET has a potential neuroprotective effect against the adverse behavioral and neurochemical changes induced by hypothyroidism in rats. (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 30, 2022 Category: Endocrinology Source Type: research
Metabolic syndrome is associated with impaired survival after surgery for pancreatic neuroendocrine tumors
Introduction: Pancreatic neuroendocrine tumors (pNETs) are a heterogeneous group of neoplasms. Surgery is the only curative treatment option. However, our understanding of predictors of survival after surgery remains incomplete. The aim of the study was to evaluate metabolic syndrome (MetS) as a prognostic factor in pNET.
Methods: In a retrospective single centre cohort study, we examined the influence of MetS in 120 patients with curative intended resection of pNETs on overall survival (OS), recurrence free survival (RFS) and outcome after recurrence.
Results: MetS was present in 32 patients (26.6%). Patients with MetS ...
Source: Neuroendocrinology - March 30, 2022 Category: Endocrinology Source Type: research
Disrupted Circadian Control of Hormonal Rhythms and Anticipatory Thirst by Dim Light at Night
Conclusion: Our findings highlight compromised time-keeping function of the central clock and multiple circadian outputs, through which ALAN disturbs the temporal organization of physiology and behavior. (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 22, 2022 Category: Endocrinology Source Type: research
The Impact of COVID-19 and Vaccine on the Human Nervous System
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has precipitated a global health crisis of unprecedented proportions. Due to its severe impact, multiple COVID-19 vaccines are being developed, approved, and manufactured rapidly. However, some serious adverse events (AEs) were reported after the application of them, significantly increasing concerns about the safety and efficacy of the vaccines and doubts about the necessity of vaccination. Particularly, previous vaccination campaigns have shown us that partial vaccination can induce neurologic AEs. Herein, we ...
Source: Neuroendocrinology - March 22, 2022 Category: Endocrinology Source Type: research
The impact of COVID-19 and vaccine on human nervous system
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has precipitated a global health crisis of unprecedented proportions. Due to its severe impact, multiple COVID-19 vaccines are being developed, approved, and manufactured rapidly. However, some serious adverse events (AEs) were reported after the application of them, significantly increasing concerns about the safety and efficacy of the vaccines and doubts about the necessity of vaccination. Particularly, previous vaccination campaigns have shown us that partial vaccination can induce neurologic AEs. Herein, we ...
Source: Neuroendocrinology - March 22, 2022 Category: Endocrinology Source Type: research
Insulin resistance in the brain: Evidence supporting a role for inflammation, reactive microglia, and the impact of biological sex
Increased intake of highly processed, energy-dense foods combined with a sedentary lifestyle are helping fuel the current overweight and obesity crisis, which is more prevalent in women than in men. Although peripheral organs such as adipose tissue contribute to the physiological development of obesity, emerging work aims to understand the role of the central nervous system to whole body energy homeostasis and development of weight gain and obesity. The present review discusses the impact of insulin, insulin resistance, free fatty acids, and inflammation on brain function and how these differ between the males and females ...
Source: Neuroendocrinology - March 11, 2022 Category: Endocrinology Source Type: research
The contribution of cell imaging to the study of anterior pituitary function and its regulation
(Source: Neuroendocrinology)
Source: Neuroendocrinology - March 1, 2022 Category: Endocrinology Source Type: research
Irisin improves high-fat diet-induced sexual dysfunction in obese male rats
Conclusion: Irisin provided a marked enhancement of HFD-induced decrease in libido, potency, sexual performance, and erection in SBT. Taken together, our results emphasize that irisin has a restorative and improver role in HFD-induced reproductive dysfunctions in obese male rats. (Source: Neuroendocrinology)
Source: Neuroendocrinology - February 21, 2022 Category: Endocrinology Source Type: research
FAM83A promotes the progression and metastasis of human pancreatic neuroendocrine tumors by inducing the epithelial-mesenchymal transition via the PI3K/AKT and ERK pathways
Background: Family with sequence similarity 83, member A (FAM83A) has been reported to play an important role in cancer progression and metastasis. The purpose of this study was to clarify the role and mechanism of FAM83A in pancreatic neuroendocrine tumors (PanNETs).
Methods: PanNET specimens and adjacent nontumor pancreatic tissues obtained from 68 patients who underwent curative surgery for PanNETs were assessed using immunochemical staining to identify FAM83A expression. The relationships between FAM83A expression, clinicopathological parameters and prognosis were statistically analyzed. PanNET cell lines were used to...
Source: Neuroendocrinology - February 16, 2022 Category: Endocrinology Source Type: research
An In Vitro Study on the Contractility of Epileptic Myometrium and Effects of Antiepileptic Agents on Oxytocin-Induced Contractions of Myometrium Isolated from Absence Epileptic WAG/Rij Rats
Background/Aims: To determine whether spontaneous and stimulated contractile activity of myometrium in epileptic rats is different from healthy ones and whether anti-epileptic drugs (AEDs) have any direct influence on myometrial contractility.
Methods: Myometrial strips from nonpregnant and pregnant adult epileptic WAG/Rij and Wistar rats were suspended in organ bath containing physiological salt solution (37 °C and pH 7.4, aerated with 95% oxygen-5% CO2), and isometric contractions were recorded. Effects of cumulative concentrations of selected AEDs including phenytoin, levetiracetam and valproic acid alone and in combi...
Source: Neuroendocrinology - February 15, 2022 Category: Endocrinology Source Type: research
Acute but not chronic central administration of the neuropeptide 26RFa (QRFP) improves glucose homeostasis in obese/diabetic mice
Conclusion: Our data indicate that the central beneficial effect of 26RFa on glucose homeostasis, by potentiating glucose-stimulated insulin secretion, is preserved in HF mice. However, chronic administration of the neuropeptide is unable to balance glycemia in these pathophysiological conditions, suggesting that the hypothalamic 26RFa/GPR103 neuropeptidergic system mainly affects short term regulation of glucose metabolism. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 28, 2022 Category: Endocrinology Source Type: research
Is serotonin the missing link between COVID-19 course of severity in patients with diabetes and obesity?
COVID-19 pandemic is an intriguing infectious condition with multisystem manifestations and variable outcomes that are influenced by the concomitant presence of non-communicable diseases, such as obesity, diabetes, and cardiovascular disease, which were previously well-established pandemics. In addition, social, ethnic, behavioral factors were also demonstrated to play a role on the patients and populations` biological response to the condition, and therefore are considered global syndemics. Although, an enormous progress towards understanding mechanisms of SARS-CoV-2 infection has been made, there are still many areas of ...
Source: Neuroendocrinology - January 21, 2022 Category: Endocrinology Source Type: research
