Vertebral fractures associated with spinal sagittal imbalance and quality of life in acromegaly: a radiographic study with eos 2d/3d technology
Conclusions: In acromegaly, VFs may be associated with spine deformities and sagittal imbalance, spine arthropathy, impaired QoL and disability. (Source: Neuroendocrinology)
Source: Neuroendocrinology - September 24, 2020 Category: Endocrinology Source Type: research
Multiple Endocrine Neoplasia Type 1 (MEN1) and the Pancreas -
Diagnosis and Treatment of Functioning and Non-Functioning Pancreatic and Duodenal Neuroendocrine Neoplasia within the MEN1 Syndrome – An International Consensus Statement
The better understanding of the biological behavior of MEN1 organ manifestations and the in-crease in clinical experience warrant a revision of previously published guidelines.
DP-NENs are still the second most common manifestation in MEN1 and, besides NENs of the thymus, remain a leading cause of death. DP-NENs are thus of main interest in the effort to re-evaluate recommendations for their diagnosis and treatment. Especially over the last two years, more clinical experience has documented the follow-up of treated and untreated (natural-course) DP-NENs.
It was the aim of the international consortium of experts in endocr...
Source: Neuroendocrinology - September 23, 2020 Category: Endocrinology Source Type: research
Understanding the treatment algorithm of patients with metastatic pancreatic neuroendocrine neoplasms: A single-institution retrospective analysis comparing outcomes of chemotherapy, molecular targeted therapy and peptide receptor radionuclide therapy in 255 patients
This study suggests that PRRT is associated with superior clinical outcomes relative to other systemic therapies for G2 metastatic PNET. Prospective studies are required to confirm these observations. (Source: Neuroendocrinology)
Source: Neuroendocrinology - September 17, 2020 Category: Endocrinology Source Type: research
A ‘watch and wait’ strategy involving regular endoscopic surveillance is safe for many patients with small, sporadic, grade 1, non-ampullary, non-functioning duodenal neuroendocrine tumours
Introduction
Duodenal neuroendocrine tumours (d-NETs) are rare, but are increasing in incidence. Current ENETS guidelines advocate resection of all localised d-NETs. However, ‘watch and wait’ may be appropriate for some localised, small, grade 1, non-functioning, non-ampullary d-NETs. We evaluated whether patients with such d-NETs who chose ‘watch and wait’ involving regular endoscopic surveillance had equivalent disease-related outcomes to patients undergoing en doscopic or surgical resection.
Methods
Retrospective review of patients with histologically confirmed d-NETs at Liverpool ENETS Centre of Excellence 2...
Source: Neuroendocrinology - September 15, 2020 Category: Endocrinology Source Type: research
Development of the Functional Assessment of Cancer Therapy-Carcinoid Syndrome Symptom Index (FACT-CSI)
Conclusions: The FACT-CSI is a content-relevant, symptom-focused index reflecting the highest priority and clinically relevant symptoms and concerns of people with CS. (Source: Neuroendocrinology)
Source: Neuroendocrinology - September 9, 2020 Category: Endocrinology Source Type: research
Subject Index Vol. 110, No. 9-10
Neuroendocrinology 2020;110:890 (Source: Neuroendocrinology)
Source: Neuroendocrinology - August 26, 2020 Category: Endocrinology Source Type: research
Author Index Vol. 110, No. 9-10
Neuroendocrinology 2020;110:889 (Source: Neuroendocrinology)
Source: Neuroendocrinology - August 26, 2020 Category: Endocrinology Source Type: research
Title pages
Neuroendocrinology 2020;110:723 –726 (Source: Neuroendocrinology)
Source: Neuroendocrinology - August 26, 2020 Category: Endocrinology Source Type: research
Reliability and Agreement of Radiological and Pathological Tumor Size in patients with MEN1-Related Pancreatic Neuroendocrine Tumors: Results from a Population-Based Cohort
Background: Pancreatic neuroendocrine tumors (pNETs) have a high prevalence in patients with multiple endocrine neoplasia type 1 (MEN1) and are the leading cause of death. Tumor size is still regarded as the main prognostic factor and therefore used for surgical decision making. We assessed reliability and agreement of radiological and pathological tumor size in a population-based cohort of patients with MEN1-related pNETs.
Methods: Patients were selected from the Dutch MEN1 database if they had undergone a resection for a pNET between 2003 and 2018. Radiological (magnetic resonance imaging (MRI), computed tomography (CT)...
Source: Neuroendocrinology - July 27, 2020 Category: Endocrinology Source Type: research
A plasma protein biomarker strategy for detection of small intestinal neuroendocrine tumors
Conclusion: This interim analysis demonstrate that a multi-biomarker/machine learning strategy improve diagnostic accuracy of patients with SI-NET at the time of diagnosis, especially in patients with normal CgA levels. The results indicate that this multi-biomarker strategy can be useful for early detection of SI-NETs at presentation and conceivably detect recurrence after radical primary resection. (Source: Neuroendocrinology)
Source: Neuroendocrinology - July 27, 2020 Category: Endocrinology Source Type: research
Tumour Growth Rate to predict the outcome of patients with Neuroendocrine Tumours: Performance and sources of variability
Introduction: Tumor growth rate (TGR), percentage of change in tumor volume/month, has been previously identified as an early radiological biomarker for treatment monitoring in neuroendocrine tumors (NETs) patients. We assessed the performance and reproducibility of TGR 3 months (TGR3m) as a predictor factor of progression-free survival (PFS), including the impact of imaging method and reader variability.
Methods: Baseline and 3-months ( ±1month) CT/MRI images from patients with advanced, grade 1-2 NETs were retrospectively reviewed by 2 readers. Influence of number of targets, tumor burden and location of lesion on the ...
Source: Neuroendocrinology - July 26, 2020 Category: Endocrinology Source Type: research
Cardiac Metastases in Patients with Neuroendocrine Tumours: Clinical Features, Therapy Outcomes, and Prognostic Implications
Conclusions: Clinical features of NET CM ranged from asymptomatic patients to heart failure. Concomitant bone or pancreatic metastases and NT pro-BNP levels> 2 ULN predicted shorter survival time. PRRT serves as a feasible therapy with promising survival benefits, however more data are needed. (Source: Neuroendocrinology)
Source: Neuroendocrinology - July 26, 2020 Category: Endocrinology Source Type: research
A Ki-67 Index to Predict Treatment Response to the Capecitabine Temozolomide (CAPTEM) Regimen in Neuroendocrine Neoplasms: A Retrospective Multicenter Study
Conclusions The overall response rate (ORR) and disease control rate (DCR) of the entire cohort (N = 151) were 26.5% and 76.2%, respectively, with a median progression-free survival (PFS) of 12.0 months. CAR T analysis showed that patients with the Ki-67 range group 10-40% demonstrated a significantly higher ORR than those with Ki-67> 40% and (Source: Neuroendocrinology)
Source: Neuroendocrinology - July 14, 2020 Category: Endocrinology Source Type: research
Maternal Motivation: Exploring the Roles of Prolactin and Pup Stimuli
Motherhood entails increased motivation for pups, which become strong reinforcers and guide maternal behaviours. This depends on steroids and lactogens acting on the brain of females during pregnancy and postpartum. Since virgin female mice exposed to pups are nearly spontaneously maternal, the specific roles of endocrine and pup-derived signals in the induction of maternal motivation remain unclear. This work investigates maternal motivation in dams and virgin female mice, using a novel variant of the pup retrieval paradigm, the Motivated Pup Retrieval Test. We also analyse the role of prolactin and of stimuli derived fro...
Source: Neuroendocrinology - July 8, 2020 Category: Endocrinology Source Type: research
Sensitivity and Specificity of the NETest: A Validation Study
Conclusions: The sensitivity of the NETest is exceptionally high (>95%) in a population of metastatic, well-differentiated NETs. Specificity within a healthy population of patients is exceptionally high when using a normal range of 0-20% but relatively low when evaluating patients with other GI malignancies. (Source: Neuroendocrinology)
Source: Neuroendocrinology - July 1, 2020 Category: Endocrinology Source Type: research
