Australasian consensus statement on the identification, prevention and management of hormonal crises in patients with neuroendocrine neoplasms (NENs) undergoing peptide receptor radionuclide therapy (PRRT)
Hormonal crises are a rare but increasingly recognised phenomenon following peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine neoplasms (NENs). Due to the paucity of published studies, approaches to the identification, prevention and management of risk factors are inconsistent between different institutions. This consensus statement aims to provide guidance in patients undergoing PRRT. Our statement has been created on the basis of clinical demand and concerns regarding the precipitation of hormonal crises. A formal literature review was conducted to identify available studies. A total of 19 Aust...
Source: Neuroendocrinology - September 1, 2022 Category: Endocrinology Source Type: research
Excitatory effects of astrocytic hydrogen sulfide on the electrical activity of oxytocin neurons in the supraoptic nucleus
Conclusions: These findings indicate that the auto-excitatory effect of OT on OT neurons is mediated by H2S from astrocytes at least partially and astrocytic H2S can elicit retraction of astrocyte processes that subsequently increase OT neur onal excitability. (Source: Neuroendocrinology)
Source: Neuroendocrinology - August 31, 2022 Category: Endocrinology Source Type: research
Efficacy and Safety of Lanreotide Autogel and Temozolomide Combination Therapy in Progressive Thoracic Neuroendocrine Tumors (carcinoid): Results from the Phase 2 ATLANT Study
Introduction: Lanreotide autogel (LAN) and temozolomide (TMZ) are guidelines-recommended monotherapies for thoracic neuroendocrine tumors (carcinoids; T-NETs) but prospective data for both combined and monotherapies are lacking. ATLANT (NCT02698410) evaluated efficacy and safety of LAN/TMZ in progressive T-NETs.
Methods: ATLANT was a 12-month, Italian, phase 2, single-arm, open-label, multicenter pilot study. Eligible patients had unresectable, locally-advanced/metastatic, well-/moderately-differentiated T-NETs with radiological progression. Patients received subcutaneous LAN 120 mg every 28 days and oral TMZ 250 mg/day ...
Source: Neuroendocrinology - August 31, 2022 Category: Endocrinology Source Type: research
The Involvement of the Hypothalamus-Pituitary-Adrenal Axis in the Development of Hyperalgesia During the Early Postoperative Period in Postmenopausal Patients
Conclusion: The results suggest that adrenocortical steroidogenic activity favoring the production of cortisol over DHEA after surgery may contribute to the development of hyperalgesia during the early postoperative period. (Source: Neuroendocrinology)
Source: Neuroendocrinology - August 29, 2022 Category: Endocrinology Source Type: research
Inhibition of hypothalamic FTO activates STAT3 signal through ERK1/2 associated with reductions in food intake and body weight
Conclusion: our in-vitro and in-vivo data suggest that the inhibition of hypothalamic FTO could activate STAT3 through ERK1/2, which is potentially associated with reductions in food intake and body weight. (Source: Neuroendocrinology)
Source: Neuroendocrinology - August 26, 2022 Category: Endocrinology Source Type: research
Alterations in Hypothalamic Mechanisms Associated with Reduced Suckling-Induced Prolactin Secretion in the Lactation-Deficient OFA < b > < i > hr < /i > < /b > / < b > < i > hr < /i > < /b > Rat
Conclusion: The different patterns of TH, opioids, their R, and PRL signaling inhibitor expression with conserved TH activation by suckling may disturb the balance between stimulation and inhibition of PRL release resulting in impaired suckling-induced PRL secretion in OFA rats.Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - August 26, 2022 Category: Endocrinology Source Type: research
Alterations in hypothalamic mechanisms associated with reduced suckling-induced PRL secretion in the lactation deficient OFA hr/hr rat
Conclusion: different patterns of TH, opioids, their R, and PRL signaling inhibitors expression with conserved TH activation by suckling may disturb the balance between stimulation and inhibition of PRL release resulting in impaired suckling-induced PRL secretion in OFA rats. (Source: Neuroendocrinology)
Source: Neuroendocrinology - August 26, 2022 Category: Endocrinology Source Type: research
Effects of Intranasal Insulin Administration on Cerebral Blood Flow and Cognitive Performance in Adults: A Systematic Review of Randomized, Placebo-Controlled Intervention Studies
Conclusions. Region-specific changes in CBF after intranasal insulin administration were affected by obesity, T2D, and normal aging, indicating altered brain insulin sensitivity. Future RCTs should investigate longer-term effects of intranasal insulin and explore potential associations between effects on CBF and cognitive performance. (Source: Neuroendocrinology)
Source: Neuroendocrinology - August 24, 2022 Category: Endocrinology Source Type: research
Effect of Calcium-Sensitive Receptor Agonist R568 on Gastric Motility and the Underlying Mechanism
Conclusion: Activation of the gastrointestinal CaSR inhibited gastric motility in vivo and ex vitro. Transmitting nutrients signals to the brain through the vagal afferent nerve, modulating the cholinergic and nitrergic system in the enteric nervous system, and inhibiting activity of pacemaker ICCs in the myenteric plexus are involved in the mechanism of CaSR in gastric motility suppression. (Source: Neuroendocrinology)
Source: Neuroendocrinology - August 11, 2022 Category: Endocrinology Source Type: research
Use of High-Dose Androgens Is Associated with Reduced Brain-Derived Neurotrophic Factor in Male Weightlifters
Conclusion: Lower circulating BDNF concentrations in current and past androgen users suggest that high-dose androgen exposure triggers persistent changes in BDNF expression. Further studies are needed to verify the relationship and its potential clinical implications. (Source: Neuroendocrinology)
Source: Neuroendocrinology - August 9, 2022 Category: Endocrinology Source Type: research
Use of high-dose androgens is associated with reduced brain derived neurotrophic factor in male weightlifters
This study examined the association between long-term androgen exposure and BDNF levels, and the links between BDNF, heavy resistance exercise, hormones, androgens and mental health.
Methods: We measured serum levels of BDNF and sex steroid hormones in male weightlifters (N=141) with a history of current (n=59), past (n=29) or no (n=52) androgen use. All participants completed questionnaires assessing maximum strength and measures of anxiety and depression. Group differences in BDNF were tested using general linear models adjusting for age, and associations between BDNF and strength, anxiety and depression using Pearson â...
Source: Neuroendocrinology - August 9, 2022 Category: Endocrinology Source Type: research
Systemic ghrelin treatment induces rapid, transient and asymmetric changes in the metabolic activity of the mouse brain
Conclusion: Systemically-injected ghrelin transiently and asymmetrically affects the metabolic activity of the brain of male mice in a wide range of areas, in a food intake independent manner. The neurobiological bases of such asymmetry seem to be independent of the accessibility of ghrelin into the brain. (Source: Neuroendocrinology)
Source: Neuroendocrinology - July 29, 2022 Category: Endocrinology Source Type: research
Diagnostic strategy and prognostic factors for ectopic adrenocorticotropic hormone syndrome: a retrospective study of 64 cases
Conclusion: CT is first-choice in tumor localization in EAS. CT in combination with a nuclear medici ne or molecular imaging modality is necessary for further identification of an ectopic source. Serum potassium (Source: Neuroendocrinology)
Source: Neuroendocrinology - July 26, 2022 Category: Endocrinology Source Type: research
Exposure to either bisphenol A or S represents a risk for crucial behaviors for pup survival, such as spontaneous maternal behavior in mice
In this study we focused on the analysis of the effects of low-dose (i.e., 4 µg/kg body weight/day, EFSA TDI for BPA) BPA or BPS exposure throughout pregnancy and lactation in C57BL/6J mice.
During the first postnatal week we observed the spontaneous maternal behavior. At the pups' weaning, we sacrificed the dams and analyzed the oxytocin system, involved in the control of the maternal care, in the hypothalamic magnocellular nuclei.
At birth, pups from BPA-treated dams tended to have lower male-to-female ratio compared to controls, while the opposite was observed among BPS litters. During the first postnatal week, offsp...
Source: Neuroendocrinology - July 18, 2022 Category: Endocrinology Source Type: research
Delivery-Dependent Shift in Oxytocin-Responsive Cell Population in the Central Amygdala of the Female Rat
Conclusion: These results indicate that the responses of CeA cells to an OT receptor agonist markedly change around delivery, which might play a role in controlling the labor-related pain and post-delivery emotional complications. (Source: Neuroendocrinology)
Source: Neuroendocrinology - July 4, 2022 Category: Endocrinology Source Type: research
