Inhibition of Heat Shock Factor 1 Enhances Repressive Molecular Mechanisms on the < b > < i > POMC < /i > < /b > Promoter
Conclusions: These data show that HSF1 regulatesPOMC transcription. Pharmacological targeting of HSF1 may be a promising treatment option for the control of excess ACTH secretion in CD.Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - June 28, 2019 Category: Endocrinology Source Type: research
Persistent Leptin Signaling in the Arcuate Nucleus Impairs Hypothalamic Insulin Signaling and Glucose Homeostasis in Obese Mice
Conclusions: Finally, our results suggest that the constant activation of arcuate leptin signaling in DIO mice increases PTP1B expression, which exerts an inhibitory effect on insulin signaling leading to impaired glucose homeostasis.Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - June 21, 2019 Category: Endocrinology Source Type: research
Systemic and local corticosteroid use is associated with reduced executive cognition, and mood and anxiety disorders
In this study, we assessed the associations between use of different corticosteroid types with cognitive and neuropsychiatric adverse effects related to high glucocorticoid exposure.
Methods: In 83,592 adults (mean age 44 years, 59% women) of the general population (Lifelines Cohort Study), we analyzed the relationship between corticosteroid use with executive cognitive functioning (Ruff Figural Fluency Test), and presence of mood and anxiety disorders (MINI survey). We perfor med additional exploration for effects of physical quality of life (RAND-36), and inflammation (high-sensitive CRP).
Results: Cognitive scores w...
Source: Neuroendocrinology - June 20, 2019 Category: Endocrinology Source Type: research
Estradiol Protects Neuropeptide Y/Agouti-related Peptide Neurons against Insulin Resistance in Females
With obesity men exhibit a higher incidence of metabolic syndrome than women in early adult life, but this sex advantage wanes in postmenopausal women. A key diagnostic of the metabolic syndrome is insulin resistance in both peripheral tissues and brain, especially in the hypothalamus. Since the anorexigenic hormone 17 β-estradiol (E2) regulates food intake in part by inhibiting the excitability of the hypothalamic neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons, we hypothesized that E2 would protect against insulin resistance in NPY/AgRP neurons with diet-induced obesity (DIO). Therefore, we did whole- cell reco...
Source: Neuroendocrinology - June 18, 2019 Category: Endocrinology Source Type: research
The Supraoptic Nucleus of the Hypothalamus Modulates Autonomic, Neuroendocrine, and Behavioral Responses to Acute Restraint Stress in Rats
Conclusion: The results indicate that SON is an important component of the neural pathway that controls autonomic, neuroendocrine, and behavioral responses induced by RS.Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - June 18, 2019 Category: Endocrinology Source Type: research
