Central GLP-1 Resistance Induced by Severe Traumatic Brain Injury was Associated with Persistent Hyperglycemia in Humans
Introduction: Whether central glucagon-like peptide 1 (GLP-1)/GLP-1 receptor system mediated peripheral glucose homeostasis in patients with traumatic brain injury (TBI) is not clear. We aim to determine if plasma GLP-1 level could distinguish the non-survivors from the survivors during the first 14 days after TBI that could prognose 6 months mortality.
Methods: Metabolic, inflammatory, and hematological profiles were examined in 73 patients with TBI in neuro-ICU. Factors that discriminate non-survivors from survivors were determined by Two-way ANOVA. Biomarkers associated with mortality were determined by Binary logistic...
Source: Neuroendocrinology - January 31, 2023 Category: Endocrinology Source Type: research
Ultrastructural and molecular evidence of macroautophagy in functioning PitNETs and experimental pituitary tumors
Introduction: Macroautophagy is a lysosome-mediated degradation process that controls the quality of cytoplasmic components and organelles, with its regulation depending on autophagy-related proteins (Atg) and with Beclin1/Atg6 and microtubule-associated protein light chain 3 (LC3/Atg8) being key players in the mammalian autophagy. As reports on this mechanism in the field of pituitary neuropathology and neuroendocrinology are scarce, our study analyzed the ultrastructural signs of macroautophagy and the expression of Beclin1 and LC3 proteins in human functioning PitNETs and in experimental pituitary tumors. Methods: a gro...
Source: Neuroendocrinology - January 30, 2023 Category: Endocrinology Source Type: research
Paraventricular Nucleus of the Hypothalamus Oxytocin and Incubation of Heroin Seeking
Discussion: These findings reinforce oxytocin’s therapeutic pot ential for OUD, the basis for which may be driven in part by increased PVN-CeA circuit activity. Our results also suggest that oxytocin has distinct signaling and/or other mechanisms of action to produce these effects, as inhibition, but not activation, of oxytocinergic PVN neurons did not recapitul ate the suppression in heroin seeking. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 27, 2023 Category: Endocrinology Source Type: research
Post-traumatic hypopituitarism - a neglected consequence of traumatic brain injury.
Post-traumatic hypopituitarism (PTHP), described for the first time in 1918, used to be neglected and only considered a rare consequence of traumatic brain injury (TBI). The research conducted in the past 20 years, however, elucidated that it has been significantly underestimated. A PubMed search was conducted in order to find literature on the topic of post-traumatic hypopituitarism. Efforts were made to identify the wide point of view on this problem, from the historical perspective to the most recent data. The pathogenesis of PTHP is heterogenous, and various hypotheses concerning the etiology of this condition have bee...
Source: Neuroendocrinology - January 24, 2023 Category: Endocrinology Source Type: research
Genetic study in pheochromocytoma ¿is it possible to stratify the risk of hereditary pheochromocytoma?
Introduction: It is estimated that 30-40% of patients with apparently sporadic pheochromocytomas (PHEOs) have an inherited predisposition syndrome. The aim of our study was to develop a predictive model of hereditary pheochromocytoma (PHEO) based on the clinical, hormonal, and radiological features present at the diagnosis of patients with PHEOs.
Methods: A retrospective multicenter cohort study of patients with PHEOs with available genetic study from 18 tertiary hospitals. Clinical, biochemical, and radiological features were used to build a multivariate logistic regression model. The estimation of all possible equations...
Source: Neuroendocrinology - January 24, 2023 Category: Endocrinology Source Type: research
A prospective analysis of the metyrapone short test using targeted and untargeted metabolomics
Introduction
The present study aimed to prove the metyrapone short test in a day clinic to be suitable for examining the integrity of the hypothalamic-pituitary-adrenal (HPA) axis in patients with suspected secondary and tertiary adrenal insufficiency and to identify novel effector molecules in acute stress response.
Methods
44 patients were prospectively enrolled. Based on stimulated 11-deoxycortisol levels, patients were divided into a physiological (11-deoxycortisol ≥70 µg/l) and a pathological (11-deoxycortisol (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 16, 2023 Category: Endocrinology Source Type: research
Segmental Abnormalities of White Matter Microstructure in Primary Hypothyroidism Identified by Automated Fiber Quantification
Conclusion: WM microstructural integrity impairments were found in multi-segments of the multiple fiber bundles in hypothyroidism, which might be a potential mechanism of the underlying neurocognitive decline and cerebral impairment. The CCF_A might serve as a neuro biomarker for early warning of cerebral impairment in hypothyroidism. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 13, 2023 Category: Endocrinology Source Type: research
Erratum
Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 12, 2023 Category: Endocrinology Source Type: research
Potential of Ascorbic Acid supplements to Ameliorate the Deleterious Effects of Hyperuricemia on Albino Wistar Rats ’
Hippocampus (Structural and Functional study)
Conclusion: The anti-inflammatory and antioxidant properties of ascorbic acid could protect the hippocampus of albino Wistar rats against the hazardous impact of hyperuricemia. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 12, 2023 Category: Endocrinology Source Type: research
