Abstracts
Neuroendocrinology 2021;111:1 –63 (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 18, 2021 Category: Endocrinology Source Type: research
Time-restricted feeding restored insulin-growth hormone balance and improved substrate and energy metabolism in MC4RKO obese mice
Conclusions
TRF effectively decreases hyperinsulinemia and restores pulsatile GH secretion in the overeating obese mice with significant improvement in substrate and energy metabolism and body composition without reducing total caloric intake. (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 17, 2021 Category: Endocrinology Source Type: research
miRNA-mediated Drug Repurposing Unveiled Potential Candidate Drugs for Prolactinoma Treatment
We presented the transcriptomic landscape of prolactinoma through miRNA and mRNA level data integration and proposed repurposed drug candidates based on this integration. We validated our findings through testing cell viability, cell cycle phases, and PI3K/Akt protein expressions. Effects of the drugs on cell cycle phases and inhibition of PI3K/Akt pathway by all drugs gave us promising output for further studies using these drugs in the treatment of prolactinoma. This is the first study that reports miRNA-mediated repurposed drugs for prolactinoma treatment via in vitro experiments. (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 10, 2021 Category: Endocrinology Source Type: research
A putative adverse outcome pathway network for disrupted female pubertal onset to improve testing and regulation of endocrine disrupting chemicals
The average age for pubertal onset in girls has declined over recent decades. Epidemiological studies in humans and experimental studies in animals suggest a causal role for Endocrine Disrupting Chemicals (EDCs) that are present in our environment. Of concern, current testing and screening regimens are inadequate in identifying EDCs that may affect pubertal maturation, not least because they do not consider early-life exposure. Also, the causal relationship between EDC exposure and pubertal timing is still a matter of debate. To address this issue, we have used current knowledge to elaborate a network of putative Adverse O...
Source: Neuroendocrinology - February 25, 2021 Category: Endocrinology Source Type: research
Estradiol Regulates PSA-NCAM Expression and Connectivity of O-LM Interneurons in The Hippocampus of Adult Female Mice
In this study, we report that the expression of PSA-NCAM in the hippocampus, a molecule involved in the pl asticity of somatostatin expressing interneurons in the adult brain, fluctuated through the different stages of the estrous cycle. Likewise, these stages and the expression of PSA-NCAM affected the density of dendritic spines of O-LM cells. We also describe that 17β-Estradiol replacement of adult o variectomized female mice caused an increase of the perisomatic inhibitory puncta on O-LM interneurons, as well as an increase in their axonal bouton density. Interestingly, this treatment also induced a decrease in their ...
Source: Neuroendocrinology - February 4, 2021 Category: Endocrinology Source Type: research
Stereotactic Ablative Radiotherapy for the Management of Liver Metastases from Neuroendocrine Neoplasms: A Preliminary Study
Conclusions: Liver SABR is a safe and promising means of providing local control for WD-NELM. This treatment modality should be evaluated in select patients in concert with strategies to manage systemic disease. (Source: Neuroendocrinology)
Source: Neuroendocrinology - February 1, 2021 Category: Endocrinology Source Type: research
Pituitary tumors: genetic and molecular factors underlying pathogenesis and clinical behavior
Pituitary neuroendocrine tumors (PitNETs) are the most common intracranial neoplasms. Although generally benign, they can show a clinically aggressive course, with local invasion, recurrences and resistance to medical treatment. No universally accepted biomarkers of aggressiveness are available yet, and predicting clinical behavior of PitNETs remains a challenge.
In rare cases the presence of germline mutations in specific genes predisposes to PitNETs formation, as part of syndromic diseases or familial isolated pituitary adenomas (FIPA), and associates to more aggressive, invasive and drug resistant tumors. The vast majo...
Source: Neuroendocrinology - January 31, 2021 Category: Endocrinology Source Type: research
Dual-tracer (68Ga-DOTATOC and 18F-FDG-)-PET/CT scan and G1-G2 non-functioning pancreatic neuroendocrine tumors: A single-center retrospective evaluation of 124 non-metastatic resected cases
Conclusion: The complementary adoption of 68Ga-DOTATOC and 18F-FDG tracers may be valuable in the diagnostic work-up of PanNETs despite not being a game-changer for the management of PanNETs ≤ 20 mm. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 27, 2021 Category: Endocrinology Source Type: research
External validity of somatostatin analogues trials in advanced neuroendocrine neoplasms: the GETNE-TRASGU study
Conclusion: Our study evaluated the external validity of RCTs examining SSAs in the real world, as well as the main effect-modifying factors (progression status, symptoms, tumor site, specific metastases, and analytical data).. Our results indicate that both octreotide LAR and lanreotide autogel h ad a similar effect on PFS. Consequently, both represent valid alternatives in patients with well-differentiated, metastatic GEP-NENs. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 27, 2021 Category: Endocrinology Source Type: research
Coordinated action of CRH and cortisol shapes acute stress-induced behavioural response in zebrafish
Conclusions: The results suggest that the stress-induced hyperactivity is induced by the CRH/CRHR1 system, while the temporal activation of cortisol production and the associated GR/MR signalling is essential for prolonging the stressor-induced hypera ctivity. This study underscores the importance of systems-level analysis to assess stress responsivity. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 26, 2021 Category: Endocrinology Source Type: research
Prolactin response to metformin in cabergoline-resistant prolactinomas: a pilot study
Conclusion: Metformin addition to ongoing high dose cabergoline treatment in patients with cabergoline-resistant prolactinomas failed to show a consistent inhibitory effect in serum prolactin levels. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 20, 2021 Category: Endocrinology Source Type: research
Biological and psychological stress correlates are linked to glucose metabolism, obesity and gender roles in women
Conclusion. Considering the increased risk of unfavorable metabolic, cardiovascular and also mental health outcome in obe se women, a higher BMI in women with predominant female gender self-identification may be relevant for clinical risk assessment. The broad range of interacting biological, psychological and gender-related parameters calls for an integrative management of both mental and endocrinological health. Howe ver, the exploratory nature of the study calls for replication in larger samples before definite conclusion can be drawn. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 17, 2021 Category: Endocrinology Source Type: research
Cell-free dna and clinical characteristics in patients with small intestinal or pancreatic neuroendocrine tumors
Background: Neuroendocrine tumors (NETs) are rare and characterized by a heterogeneous clinical course and an unmet need for better prognostic markers. Plasma cell-free DNA (cfDNA) has prognostic value in other malignancies but is not previously investigated in NETs. We studied cfDNA levels in patients with mainly low grade small intestinal (siNET) or pancreatic NET (pNET) and evaluated the prognostic potential of cfDNA.
Material and methods: We included 70 NET patients, siNET(n=50) and pNET(n=20). Plasma cfDNA levels were determined by droplet digital PCR for the Beta-2-microglobulin gene every six months during a period...
Source: Neuroendocrinology - January 17, 2021 Category: Endocrinology Source Type: research
Dynamic tests in pituitary endocrinology: pitfalls in interpretation during aging
Aging and age-related diseases represent hot topics of current research. Progressive damage in morphology and function of cells and tissue characterizes the normal process of aging, that is influenced by both genetic and environmental factors. The ability of each individual to adapt to these stressors defines the type of aging and the onset of age-related diseases (i.e. metabolic syndrome, inflammatory disorders, cancer and neurodegenerative diseases). The endocrine system plays a critical role in this process, because of its complex relationships with brain, immune system, and skeletal muscle; thus, alterations in hormona...
Source: Neuroendocrinology - January 14, 2021 Category: Endocrinology Source Type: research
FAS and Subsequent Therapies in Pancreatic Neuroendocrine Tumors
We evaluated outcomes of treatment with 5-fluorouracil (5-FU), doxorubicin, and streptozocin (FAS) in well-differentiated pancreatic neuroendocrine tumors (PanNETs) and its impact on subsequent therapy (everolimus or temozolomide). Advanced PanNET patients treated at our center from 1992 to 2013 were retrospectively reviewed. Patients received bolus 5-FU (400 mg/m2), streptozocin (400 mg/m2) (both IV, days 1-5) and doxorubicin (40 mg/m2 IV, day 1) every 28 days. Overall response rate (ORR) was assessed using RECIST version 1.1. Of 243 eligible patients, 220 were evaluable for ORR, progression-free survival (PFS), and toxic...
Source: Neuroendocrinology - January 11, 2021 Category: Endocrinology Source Type: research
