Sub-chronic restraint stress suppresses sexual potency and erection efficiency by targeting the hypothalamic-pituitary-testicular axis and the NO/cGMP/PDE5 α pathway in adult rats.
Conclusion: The current findings suggest that psychological stressors, su ch as restraint stress, cause erectile dysfunction in adult male rats by modulating the hypothalamic-pituitary-testicular axis, oxidative balance, penile fibrosis, and the NO/cGMP/PDE5α pathway of penile erection. (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 16, 2022 Category: Endocrinology Source Type: research
Contents Vol. 112, 2022
Neuroendocrinology 2022;112:I –VIII (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 16, 2022 Category: Endocrinology Source Type: research
Acknowledgement to Reviewers
Neuroendocrinology 2022;112:1261 –1262 (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 16, 2022 Category: Endocrinology Source Type: research
New View on the Impact of the Low-Frequency Electromagnetic Field (50 Hz) on Stress Responses: Hormesis Effect
Introduction: Low-frequency electromagnetic field (50 Hz) (EMF) can modify crucial neuronal processes. Existing data indicate that exposure to EMF may represent a mild stressor and contribute to disturbances of the hypothalamic-pituitary-adrenal (HPA) axis. The important regulatory pathways controlling HPA axis activity include two types of corticosteroid receptors: mineralocorticoid receptors (MRs) and glucocorticoid receptors. They are particularly abundant in the hippocampus, a key locus of HPA axis feedback control. The research aimed at determining whether (1) EMF exhibits hormesis, it means bidirectional action depen...
Source: Neuroendocrinology - November 2, 2022 Category: Endocrinology Source Type: research
New view on the impact of the low-frequency electromagnetic field (50 Hz) on stress responses – hormesis effect
Discussion: Our data suggest that exposure to EMF can establish a new “set-point” for HPA axis activity. The direction and dynamics of this process depend on the intensity of EMF and the number of exposures. EMF of 1 mT induced an adaptive stress response, but 7 mT EMF caused sensitization. Consequently, EMF changed the vulnerability of the organism to a subsequen t stress factor. We have also shown the increase of MR mRNA abundance in hippocampus of 1 mT EMF exposed rats, which can represent the possible neuroprotective response and suggest therapeutic properties of electromagnetic fields. (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 2, 2022 Category: Endocrinology Source Type: research
Lifestyle factors and development and natural course of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): a review of the literature
Conclusion: Different tissues, i.e., pancreas and small intestine, may respond differently to exposure to alcohol and smoking. Evidence for diet so far is too limited to draw conclusions. Diabetes seems to be an important risk factor for the development of pancreatic NET w ith a protective role in disease progression, while BMI is not unequivocally associated with development and prognosis of NETs. Hence, our findings suggest that lifestyle factors play an important role in NET development as disease course. Future research should consider lifestyle as an influence on disease progression and treatment response. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 26, 2022 Category: Endocrinology Source Type: research
Induction of oxidative stress and alteration of synaptic gene expression in newborn hippocampal granule cells after developmental exposure to Aroclor 1254
Conclusion: Our data suggest that gene expression in newborn granule cells is disrupted by Aroclor 1254 and provide clues to the effects of endocrine disrupting chemicals on the brain. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 18, 2022 Category: Endocrinology Source Type: research
Behavioral and Transcriptional Effects of Short or Prolonged Fasting on the Memory Performances of < b > < i > Lymnaea stagnalis < /i > < /b >
Discussion: Our results suggest that short-term fasting creates an optimal internal state inL. stagnalis’ CNS, allowing a spike in insulin release and an upregulation of genes involved in neuroplasticity. Long-term fasting, instead, upregulates genes involved in energy homeostasis and animal survival. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 12, 2022 Category: Endocrinology Source Type: research
Behavioral and transcriptional effects of short or prolonged fasting on the memory performances of Lymnaea stagnalis
Discussion: Our results suggest that sh ort-term fasting creates an optimal internal state in L. stagnalis’ CNS, allowing a spike in insulin release and an upregulation of genes involved in neuroplasticity. Long-term fasting, instead, upregulates genes involved in energy homeostasis and animal survival. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 12, 2022 Category: Endocrinology Source Type: research
Extracellular vesicles and the Stress System
Extracellular vesicles (EVs) are membrane-enclosed nanoparticles that contain various biomolecules, including nucleic acids, proteins, and lipids, and are manufactured and released by virtually all cell types. There is evidence that EVs are involved in intercellular communication, acting in an autocrine, paracrine, or/and endocrine manner. EVs are released by the cells of the central nervous system (CNS), including neurons, astrocytes, oligodendrocytes and microglia, and have the ability to cross the blood brain barrier (BBB) and enter the systemic circulation. Neuroendocrine cells are specialized neurons that secrete horm...
Source: Neuroendocrinology - September 22, 2022 Category: Endocrinology Source Type: research
Estradiol Replacement as a Potential Enhancer of Working Memory and Neuroplasticity in Hypogonadal Trans Women
Discussion: These results may have clinical implications for the therapeutic effects of estradiol replacement serving as a protective factor against cognitive decline and impairment for trans women post-gonadectomy. (Source: Neuroendocrinology)
Source: Neuroendocrinology - September 21, 2022 Category: Endocrinology Source Type: research
Investigating the Effects of Maternal Separation on Hypothalamic-Pituitary-Adrenal Axis and Glucose Homeostasis under Chronic Social Defeat Stress in Young Adult Male Rat Offspring
Conclusion: MS exacerbated HPA axis overactivity and the endocrine pancreas dysfunctions under CSDS. The intensified corticosterone secretion and the diminished content of pancreatic CRFR1 protein could be involved in the reduced β-cell number and islets’ insulin secretion under CSDS. The decreased muscular FKBP51 content might be a homeostatic response to slow down insulin resistance development under chronic stress.Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - September 9, 2022 Category: Endocrinology Source Type: research
Investigating the Effects of Maternal Separation on Hypothalamic –Pituitary–Adrenal Axis and Glucose Homeostasis under Chronic Social Defeat Stress in Young Adult Male Rat Offspring
Conclusion: MS exacerbated HPA axis overactivity and the endocrine pancreas dysfunctions under CSDS. The intensified corticosterone secretion and the diminished content of pancreatic CRFR1 protein could be involved in the reduced β-cell number and islets’ insulin secretion under CSDS. The decreased muscular FKBP51 protein content might be a homeostatic response to slow down insulin resistance development under chronic stress. (Source: Neuroendocrinology)
Source: Neuroendocrinology - September 9, 2022 Category: Endocrinology Source Type: research
Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters
Conclusions: This study reveals multiple mechanisms by which the components of a common FR mixture are developmentally neurotoxic and that the OPFRs may be the compounds of greatest concern. (Source: Neuroendocrinology)
Source: Neuroendocrinology - September 8, 2022 Category: Endocrinology Source Type: research
Australasian Consensus Statement on the Identification, Prevention, and Management of Hormonal Crises in Patients with Neuroendocrine Neoplasms Undergoing Peptide Receptor Radionuclide Therapy
Hormonal crises are a rare but increasingly recognized phenomenon following peptide receptor radionuclide therapy (PRRT) in patients with neuroendocrine neoplasms (NENs). Due to the paucity of published studies, approaches to the identification, prevention, and management of risk factors are inconsistent between different institutions. This consensus statement aimed to provide guidance for NEN patients undergoing PRRT. Our statement has been created on the basis of clinical demand and concerns regarding the precipitation of hormonal crises. A formal literature review was conducted to identify available studies. A total of ...
Source: Neuroendocrinology - September 1, 2022 Category: Endocrinology Source Type: research
