Expression of Insulin-like Growth Factor Type 1 Receptor is Linked to Inflammation in Adamantinomatous Craniopharyngioma
Conclusions High expression of IG F1R might promote inflammation of ACP, which might be an unfavorable factor for pituitary function and prognosis. The high expression of IGF1R in tumor cell stem-like cells might inhibit the expression of p-ERK and promote the generation of inflammatory factors. Insulin-like growth factor type 1 rec eptor plays a stemness maintenance role in ACP and regulates the production of inflammatory factors through a p-ERK pathway, which suggests that targeting IGF1R and p-ERK might provide a new direction for alleviating tumor inflammation. (Source: Neuroendocrinology)
Source: Neuroendocrinology - December 13, 2021 Category: Endocrinology Source Type: research

Advanced imaging approaches to reveal molecular mechanisms governing neuroendocrine secretion
Identification of the molecular mechanisms governing neuroendocrine secretion and resulting intercellular communication is one of the great challenges of cell biology to better understand organism physiology and neurosecretion disruption-related pathologies such as hypertension, neurodegenerative or metabolic diseases. To visualize molecule distribution and dynamics below the diffraction limit, many imaging approaches have been developed and are still emerging. In this review, we provide an overview of the pioneering studies that use transmission electron microscopy, atomic force microscopy, total internal reflection micro...
Source: Neuroendocrinology - December 13, 2021 Category: Endocrinology Source Type: research

Vasopressin resets the central circadian clock in a manner influenced by sex and vasoactive intestinal polypeptide signaling
Circadian rhythms in behavior and physiology are programmed by the suprachiasmatic nucleus (SCN) of the hypothalamus. A subset of SCN neurons produce the neuropeptide arginine vasopressin (AVP), but it remains unclear whether AVP signaling influences the SCN clock directly. Here we test that AVP signaling acting through V1A and V1B receptors influences molecular rhythms in SCN neurons. V1 receptor agonists were applied ex vivo to PERIOD2::LUCIFERASE SCN slices, allowing for real-time monitoring of changes in molecular clock function. V1A/B agonists reset the phase of the SCN molecular clock in a time-dependent manner, with...
Source: Neuroendocrinology - December 2, 2021 Category: Endocrinology Source Type: research

Androgen excess increases food intake in a rat polycystic ovary syndrome model by down-regulating hypothalamus insulin and leptin signaling pathways preceding weight gain
Conclusions Androgen excess increased food intake in rats and promoted obesity by down-regulating insulin and leptin signaling in the hypothalamus, most likely by suppressing leptin levels in the CSF. (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 30, 2021 Category: Endocrinology Source Type: research

Exercise-induced adrenocorticotropic hormone response is cooperatively regulated by hypothalamic arginine vasopressin and corticotrophin-releasing hormone
Conclusion: These results lead us to hypothesize that AVP and CRH are cooperatively involved in exercise-induced ACTH response just above the LT. This may also reflect the stress response with moderate-intensity e xercise in humans. (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 30, 2021 Category: Endocrinology Source Type: research

Transcriptomic Analysis Reveals that Atf3/c-Jun/Lgals3 axis is associated with Central Diabetes Insipidus after Hypothalamic Injury
Conclusion: Our findings suggested that the Atf3/c-Jun/Lgals3 axis was associated with the microglial activation, and might participate in the loss of functional arginine vasopressin neurons in CDI after hypothalamic injury. (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 11, 2021 Category: Endocrinology Source Type: research

Contents Vol. 111, 2021
Neuroendocrinology 2021;111:I –VIII (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 9, 2021 Category: Endocrinology Source Type: research

Acknowledgement to Reviewers
Neuroendocrinology 2021;111:1270 –1272 (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 9, 2021 Category: Endocrinology Source Type: research

Coadministration of Melatonin and Insulin Improves Diabetes-Induced Impairment of Rat Kidney Function
Conclusion: The coadministration of exogenous melatonin and insulin abolished many of the deleterious effects of type 1 diabetes on rat renal function. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 21, 2021 Category: Endocrinology Source Type: research

Co-administration of melatonin and insulin improves diabetic-induced impairment of rat kidney function
Conclusion: The co-administration of exogenous melatonin and insulin abolished many of the deleterious effects of type 1 diabetes on rat renal function. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 21, 2021 Category: Endocrinology Source Type: research

Prolactin Reduces Hippocampal Parvalbumin and GABA < sub > A < /sub > Receptor Expression in Female Mice
Conclusions: These data show, for the first time, that an increase in PRL level is associated with changes in key constituent elements of inhibitory circuits in the hippocampus and may be of relevance for the alterations in cognitive function reported in hyperprolactinemia. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 19, 2021 Category: Endocrinology Source Type: research

Prolactin reduces hippocampal parvalbumin and gabaa receptor expression in female mice
Conclusions: These data show, for the first time, that an increase in PRL level is associated with changes in key constituent elements of inhibitory circuits in the hippocampus and may be of relevance for the alterations in cognitive function reported in hyperprolactinemia. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 19, 2021 Category: Endocrinology Source Type: research

Cisplatin-Based versus Carboplatin-Based Chemotherapy for Extrapulmonary Neuroendocrine Carcinomas: A Real-World Study
Conclusions: The current study suggested that cisplatin/etoposide might be associated with better overall survival compared to carboplatin/etoposide among patients with extrapulmonary NECs. It is unclear if this is related to differences in inherent responsiveness to the 2 platinum agents or due to differences in comorbidity burden between the 2 treatment groups.Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 14, 2021 Category: Endocrinology Source Type: research

Cisplatin-Based versus Carboplatin-Based Chemotherapy for Extra-Pulmonary Neuroendocrine Carcinomas; A Real-World Study.
Conclusions: The current study suggested that cisplatin/etoposide might be associated with better overall survival compared to carboplatin/etoposide among patients with extra-pulmonary NECs. It is unclear if this is related to differences in inherent responsiveness to the two platinum agents, or due to differences in comorbidity burden between the two treatment groups. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 14, 2021 Category: Endocrinology Source Type: research

Neuropeptide Cortistatin Regulates Dermal and Pulmonary Fibrosis in an Experimental Model of Systemic Sclerosis
Conclusion: We identify cortistatin as an endogenous break of skin inflammation and fibrosis. Deficiency in cortistatin could be a marker of poor prognosis of scleroderma and associated complications. Cortistatin-based therapies emerge as attractive candidates to treat severe forms of systemic sclerosis and to manage fibrosis-related side effects of bleomycin chemotherapy in oncologic patients. (Source: Neuroendocrinology)
Source: Neuroendocrinology - October 14, 2021 Category: Endocrinology Source Type: research