Dietary fibers and proteins modulate behavior via the activation of intestinal gluconeogenesis
Conclusion: IGN translates nutritional information allowing the brain to finely coordinate energy metabolism and behavior. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 10, 2021 Category: Endocrinology Source Type: research
IGF-1 Influences Gonadotropin-Releasing Hormone Regulation of Puberty
The pubertal process is initiated as a result of complex neuroendocrine interactions within the preoptic and hypothalamic regions of the brain. These interactions ultimately result in a timely increase in the secretion of gonadotropin-releasing hormone (GnRH). Researchers for years have believed that this increase is due to a diminished inhibitory tone which has applied a prepubertal brake on GnRH secretion, as well as to the gradual development of excitatory inputs driving the increased release of the peptide. Over the years, insulin-like growth factor -1 (IGF-1) has emerged as a prime candidate for playing an important r...
Source: Neuroendocrinology - January 5, 2021 Category: Endocrinology Source Type: research
Morning serum cortisol level predicts central adrenal insufficiency diagnosed by insulin tolerance test
Conclusions This is the first study that identifies a morning serum cortisol cut-off that best predict the response to ITT in order to simplify the diagnostic process in patients with suspected CAI. A new diagnostic flow chart for CAI is proposed. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 5, 2021 Category: Endocrinology Source Type: research
Meta-analysis of prognostic factors for recurrence of resected well-differentiated pancreatic neuroendocrine tumors
Well-differentiated pancreatic neuroendocrine tumors (WDPNETs) are a group of rare and heterogeneous tumors. However, the prognostic factors for recurrence after curative resection still remain controversial. We aim to illustrate the prognostic factors for recurrence of resected WDPNETs. All relevant articles published through June 2020 were identified via PubMed, Embase, Web of Science and the Cochrane Library. Articles that examined the prognostic factors of WDPNETs were enrolled. 10 articles were finally included in this study. From 1993 to 2018, 2863 patients underwent curative resection and 358 patients had recurrence...
Source: Neuroendocrinology - December 27, 2020 Category: Endocrinology Source Type: research
Insulin-like growth factor 1 (IGF-1) increases GABAergic neurotransmission to GnRH neurons via suppressing the retrograde tonic endocannabinoid signaling pathway in mice
Conclusion: These findings indicate that IGF-1 arrests the tonic retrograde endocannabinoid pathway in GnRH neurons and this disinhibition increases the release of GABA from presynaptic terminals that, in turn, activates GnRH n eurons leading to the fine-tuning of the hypothalamo-pituitary-gonadal axis. (Source: Neuroendocrinology)
Source: Neuroendocrinology - December 23, 2020 Category: Endocrinology Source Type: research
Estrous Cycle Modulation of Feeding and Relaxin-3/Rxfp3 mRNA Expression - Implications for Estradiol
Conclusion: These findings demonstrate that the RLN3/RXFP3 system is modulated by the estrous cycle and although further studies are required to better elucidate the cellular and molecular mechanisms of estradiol signaling, current results implicate the involvement of RLN3/RXFP3 system in food intake fluctuations observed across the estrous cycle in female rats. (Source: Neuroendocrinology)
Source: Neuroendocrinology - December 16, 2020 Category: Endocrinology Source Type: research
Anthropometrics and metabolic syndrome in relation to glucocorticoid receptor polymorphisms in corticosteroid users
Introduction: Corticosteroids are widely prescribed and their use has been linked to adverse cardiometabolic outcomes. A pivotal role in the action of corticosteroids is reserved for the glucocorticoid receptor (GR). Here, we assessed the relationship of glucocorticoid (GC) sensitivity altering GR polymorphisms with anthropometrics and metabolic syndrome (MetS) in corticosteroid users.
Methods: In this population-based cohort study (Lifelines) we genotyped 10,621 adult participants for GR hypersensitive (1/2 copies BclI and/or N363S) and GR resistant (1/2 copies ER22/23EK and/or 9β) variants. We assessed the relationshi...
Source: Neuroendocrinology - December 10, 2020 Category: Endocrinology Source Type: research
Acknowledgement to the Reviewers
Neuroendocrinology 2021;111:180 –182 (Source: Neuroendocrinology)
Source: Neuroendocrinology - December 9, 2020 Category: Endocrinology Source Type: research
Role for histone deacetylation in traumatic brain injury-induced deficits in neuropeptide Y in arcuate nucleus: Possible implications in feeding behaviour
Conclusions: These findings suggest that histone deacetylation at the NPY promoter persistently controls NPY function in the Arc after rMTBI. This study also demonstrates the efficacy of HDAC inhibitors in mitigating trauma-induced neuroendocrine maladaptations in the hypothalamus. (Source: Neuroendocrinology)
Source: Neuroendocrinology - December 7, 2020 Category: Endocrinology Source Type: research
Sex disparities in covid-19 severity and outcome: are men weaker or women stronger?
The COVID-19 outbreak is a global public health issue, having profound effects on most aspects of societal well-being, including physical and mental health. A plethora of studies, globally, have suggested the existence of a sex disparity in the outcome of COVID-19 patients, that is mainly due to mechanisms of viral infection, immune response to the virus, development of a hyperinflammation, and development of systemic complications, particularly thromboembolism. These differences appear to be more pronounced in elderly COVID-19 patients. Epidemiological data report a sex difference in the severity and outcome of COVID-19 d...
Source: Neuroendocrinology - November 25, 2020 Category: Endocrinology Source Type: research
Unique Metastatic Patterns in Neuroendocrine Neoplasms of Different Primary Origin
Conclusion
Almost half of NEN patients were diagnosed with synchronous metastatic disease. L-NEN have a unique metastatic pattern compared to GE- and Pan-NEN. Remarkably, an important part of L-NEN metastases were in the brain, whereas brain metastases were almost absent in GE- and Pan-NEN, indicating utility of screening in L-NEN. (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 22, 2020 Category: Endocrinology Source Type: research
Kisspeptin-54 accurately identifies hypothalamic GnRH neuronal dysfunction in men with congenital hypogonadotropic hypogonadism
Background: Hypogonadotropic hypogonadism is hypogonadism due to either hypothalamic or pituitary dysfunction. Whilst gonadotropin releasing hormone (GnRH) can directly test pituitary function, no specific test of hypothalamic function exists. Kisspeptin-54 (KP54) is a neuropeptide that directly stimulates hypothalamic GnRH-release and thus could be used to specifically interrogate hypothalamic function. Congenital Hypogonadotropic Hypogonadism (CHH) is typically due to variants in genes that control hypothalamic GnRH neuronal migration of function. Thus, we investigated whether KP54 could accurately identify hypothalamic ...
Source: Neuroendocrinology - November 22, 2020 Category: Endocrinology Source Type: research
Temozolomide Alone or Combined with Capecitabine for the Treatment of Metastatic Neuroendocrine Neoplasia: a “Real World” data analysis
Background: Neuroendocrine neoplasia (NEN) are a rare group of tumors with different prognosis and response to therapy. Their heterogeneity is dependent on the site of origin, morphology and Ki67. Temozolomide (TEM) appears to be active in metastatic NENs (mNENs) but there is limited evidence about its efficacy in gastrointestinal NENs. We analyzed “real-world” data on the use of TEM alone or in association with capecitabine (CAPTEM) in patients with mNENs. Patients and Methods: One hundred consecutive patients with advanced NENs treated with TEM or CAPTEM between 2009 and 2019 were included. A pre-treatment tumor grow...
Source: Neuroendocrinology - November 19, 2020 Category: Endocrinology Source Type: research
MRI may be able to identify the origin of neuroendocrine tumor liver metastases
Conclusions: MRI provides qualitative features that can help discriminate between hepatic metastases from pNET and those from mNET. (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 12, 2020 Category: Endocrinology Source Type: research
Publisher Correction
Neuroendocrinology (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 9, 2020 Category: Endocrinology Source Type: research
