Role for histone deacetylation in traumatic brain injury-induced deficits in neuropeptide Y in arcuate nucleus: Possible implications in feeding behaviour

Conclusions: These findings suggest that histone deacetylation at the NPY promoter persistently controls NPY function in the Arc after rMTBI. This study also demonstrates the efficacy of HDAC inhibitors in mitigating trauma-induced neuroendocrine maladaptations in the hypothalamus.
Source: Neuroendocrinology - Category: Endocrinology Source Type: research