Alterations of spontaneous cortical and subcortical activity in type 2 diabetes mellitus with and without depression
Conclusions: The abnormalities of spontaneous cortical activity in PCC and subcortical activity in the hippocampus might represent the neurobiological feature of cerebral dysfunction in T2DM. Notably, the altered subcortical activity in the right putamen might mainly associate with negative emotion in T2DM, which could be a promising biomarker for recognizing early cerebral dysfunction in depressed T2DM. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 11, 2023 Category: Endocrinology Source Type: research
Neuromechanical Dimorphism of Hypoglycemic Effect of Electroacupuncture
Conclusion: Our research has demonstrated that the TRPV1 sensory afferent nerve and sy mpathetic efferent nerve are capable of maintaining glucose homeostasis, exhibiting a distinct sexual dimorphism. Furthermore, this regulation is contingent on the EA effect. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 9, 2023 Category: Endocrinology Source Type: research
p38 and ERK1/2-dependent activation of c-Jun is required for the downregulation of oxidative stress-induced ER α in hypothalamic astrocytes
Conclusions: The current data demonstrate that oxidative stress leads to loss of ERα involving the activation of the p38 and ERK1/2 pathways a nd the induction of the c-Jun protein in hypothalamic astrocytes. C-Jun protein regulates ERα gene expression via direct transcriptional repression or involving histone acetylation modifications at ERα gene promoter sites. (Source: Neuroendocrinology)
Source: Neuroendocrinology - January 3, 2023 Category: Endocrinology Source Type: research
Increased < b > < i > Lactobacillus < /i > < /b > Abundance Contributes to Stress Resilience in Mice Exposed to Chronic Social Defeat Stress
Conclusions:Lactobacillus contributes to stress resilience, and the DR 5-HT system may play an important role during this process. The above results suggest that certain organisms in the GI tract may play an essential role in stress response and be useful in the prevention and treatment of some stress-related psychiatric disorders, such as depression. (Source: Neuroendocrinology)
Source: Neuroendocrinology - December 30, 2022 Category: Endocrinology Source Type: research
Increased Lactobacillus abundance contributes to stress resilience in mice exposed to chronic social defeat stress
Conclusions: Lactobacillus contributes to stress resilience, and the DR 5-HT system may play an important role during this process. The above results suggest that certain organisms in the GI tract may play an essential role in stress response and be useful in the prevention and treatment of some stress-related psychiatric disorders, such as depression. (Source: Neuroendocrinology)
Source: Neuroendocrinology - December 30, 2022 Category: Endocrinology Source Type: research
Obesity-induced memory deficits in female rats are oestrous cycle-dependent and linked to impaired brain kynurenine pathway metabolism
Conclusion: The results presented here indicate that the deleterious effects of obesity on learning are closely related to the oestrous cycle and associated with an impairment of the kynurenine pathway of tryptophan metabolism. (Source: Neuroendocrinology)
Source: Neuroendocrinology - December 29, 2022 Category: Endocrinology Source Type: research
Blockade of ghrelin receptor signaling enhances conditioned passive avoidance and context-associated cFos activation in fasted male rats
Interoceptive feedback to the brain regarding the body ’s physiological state plays an important role in guiding motivated behaviors. For example, a state of negative energy balance tends to increase exploratory/food-seeking behaviors while reducing avoidance behaviors. We recently reported that overnight food deprivation reduces conditioned passive a voidance behavior in male (but not female) rats. Since fasting increases circulating levels of ghrelin, we hypothesized that ghrelin signaling contributes to the ability of fasting to reduce conditioned avoidance. To test this, ad libitum-fed male rats were trained in a pas...
Source: Neuroendocrinology - December 23, 2022 Category: Endocrinology Source Type: research
Persistent organic pollutant exposure and thyroid function among 12-year-old children
Conclusion
This cross-sectional study highlights associations between some POPs and thyroid function disruption, which appears consistent with the literature. Considering that the associations were sex-specific and moderated by pubertal status in boys, complex endocrine interactions are li kely involved. (Source: Neuroendocrinology)
Source: Neuroendocrinology - December 9, 2022 Category: Endocrinology Source Type: research
Adolescence predatory risk alters social behaviors and cognitive ability and central oxytocin and vasopressin expression in adult Brandt ’s voles
Conclusion: Th ese findings demonstrate that adolescent exposure to predator risk promotes adult reproductive behavior of Brandt’s voles. Deficits in recognition ability may necessitate alterations in reproductive strategies to enhance inclusive fitness. OT and AVP systems may play a modulatory role in the alter ation of social behaviors elicited by adolescent predatory risk. (Source: Neuroendocrinology)
Source: Neuroendocrinology - December 9, 2022 Category: Endocrinology Source Type: research
Increased expression levels of soluble fms-like tyrosine kinase-1 inhibits the development of the nervous system
Introduction: Preeclampsia (PE) remains a leading cause of maternal and perinatal morbidity. At present, only limited options are available for the treatments of preeclampsia. Consequently, many patients need to terminate their pregnancy to relieve the disease. Soluble fms-like tyrosine kinase-1 (sFlt-1) is a decoy receptor of placental growth factor (PIGF) and vascular endothelial growth factor (VEGF) which can promote angiogenesis. Throughout pregnancy, the expression level of sFlt-1 continues to increase in both the mother with PE and her offspring. Material and methods: In this experiment, we generated a zebrafish line...
Source: Neuroendocrinology - December 8, 2022 Category: Endocrinology Source Type: research
Cancer associated fibroblasts induce proliferation and therapeutic resistance to everolimus in neuroendocrine tumors through STAT3 activation
Conclusion
Identifying STAT3 as the contributing pathway of this so far neglected tumor-stroma interaction has the potential to become a new therapeutic target to halt tumor growth and to restore therapeutic responsiveness in NET. (Source: Neuroendocrinology)
Source: Neuroendocrinology - December 6, 2022 Category: Endocrinology Source Type: research
TSAb Modulates Microglia M1 Polarization via Activation of the TSHR-Mediated NF- κB Signaling Pathway
Conclusions: TSAb can induce abnormal activation of microglia, polarize to the M1 phenotype, and promote the inflammatory cascade reaction, in which TSHR plays a key role in NF- κB activation and proinflammatory cytokine release. (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 28, 2022 Category: Endocrinology Source Type: research
TSAb modulates microglia M1 polarization via activation of TSHR mediated NF- κB signaling pathway
Conclusions: TSAb can induce abnormal activation of microglia, polarize to the M1 phenotype, and promote the inflammatory cascade reaction, in which TSHR plays a key role in NF-κB activation and proinflammatory cytokine release. (Source: Neuroendocrinology)
Source: Neuroendocrinology - November 28, 2022 Category: Endocrinology Source Type: research
Prognostic Factors Across Poorly Differentiated Neuroendocrine Neoplasms: a Pooled Analysis
This study aimed to analyze a large NEC case series to validate the specific prognostic factors identified in previous studies on gastro-entero-pancreatic (GEP) and lung NECs and to assess if further prognostic parameters can be isolated. Methods: A pooled analysis of four NEC retrospective studies was performed to evaluate: the prognostic role of Ki-67 cut-off, the OS according to primary cancer site, and further prognostic parameters using multivariable Cox proportional hazards model and machine-learning random survival forest (RSF). Results: 422 NECs were analyzed. The most represented tumor site was the colorectum (n=1...
Source: Neuroendocrinology - November 23, 2022 Category: Endocrinology Source Type: research
Trabecular bone score as an index of bone fragility in patients with acromegaly: a systematic review and meta-analysis
Background. Acromegaly is characterized by impaired bone quality and increased fracture risk. However, due to the pathophysiology of acromegalic osteopathy, bone mineral density (BMD) does not represent a reliable predictor for fragility fractures in this setting. Trabecular bone score (TBS) has been recently evaluated as an alternative index of skeletal fragility in acromegalic patients. However, no conclusive data are still available in this regard.
Methods. PubMed/Medline, EMBASE, Cochrane library, Ovid and CINAHL databases were systematically searched until June 2022 for studies reporting data either about the compar...
Source: Neuroendocrinology - November 22, 2022 Category: Endocrinology Source Type: research
