Effect of Calcium-Sensitive Receptor Agonist R568 on Gastric Motility and the Underlying Mechanism

Conclusion: Activation of the gastrointestinal CaSR inhibited gastric motility in vivo and ex vitro. Transmitting nutrients signals to the brain through the vagal afferent nerve, modulating the cholinergic and nitrergic system in the enteric nervous system, and inhibiting activity of pacemaker ICCs in the myenteric plexus are involved in the mechanism of CaSR in gastric motility suppression.
Source: Neuroendocrinology - Category: Endocrinology Source Type: research