Reliability and Agreement of Radiological and Pathological Tumor Size in patients with MEN1-Related Pancreatic Neuroendocrine Tumors: Results from a Population-Based Cohort

Background: Pancreatic neuroendocrine tumors (pNETs) have a high prevalence in patients with multiple endocrine neoplasia type 1 (MEN1) and are the leading cause of death. Tumor size is still regarded as the main prognostic factor and therefore used for surgical decision making. We assessed reliability and agreement of radiological and pathological tumor size in a population-based cohort of patients with MEN1-related pNETs. Methods: Patients were selected from the Dutch MEN1 database if they had undergone a resection for a pNET between 2003 and 2018. Radiological (magnetic resonance imaging (MRI), computed tomography (CT) and endoscopic ultrasonography (EUS)) and pathological tumor size were collected from patient records. Measures of agreement (Bland-Altman plots with limits of agreement (LoA) and absolute agreement) and reliability (Intraclass Correlation Coefficients (ICC) and unweighted Kappa) were calculated for continuous and categorized (
Source: Neuroendocrinology - Category: Endocrinology Source Type: research