Risk factors for recurrence in pancreatic neuroendocrine tumor and size as a surrogate in determining the treatment strategy: a Korean nationwide study
This study aimed to suggest a treatment algorithm for pancreatic neuroendocrine tumor (PNET) based on risk factors for recurrence in a large cohort.
Methods: Data of 918 patients who underwent curative intent surgery for PNET were collected from 14 tertiary centers. Risk factors for recurrence and survival analyses were performed.
Results: The 5-year disease-free survival (DFS) rate was 86.5%. Risk factors for recurrence included margin status (R1, hazard ratio [HR] 2.438; R2, HR 3.721), 2010 WHO grade (G2, HR 3.864; G3, HR 7.352), and N category (N1, HR 2.273). Size of 2 cm was significant in the univariate analysis (HR 8.511) but not in the multivariate analysis (p=0.407). Tumor size was not a risk factor for recurrence, but strongly reflected 2010 WHO grade and lymph node (LN) status. Tumors ≤2 cm had lower 2010 WHO grade, less LN metastasis (p
Source: Neuroendocrinology - Category: Endocrinology Source Type: research