Palmiwon attenuates hepatic lipid accumulation and hyperlipidemia in a menopausal rat model: Erratum
No abstract available (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Erratum Source Type: research

Subject Index
No abstract available (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Index Source Type: research

Author Index
No abstract available (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Index Source Type: research

Abstract Author Index
No abstract available (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Abstracts Source Type: research

27th Annual Meeting of The North American Menopause Society October 5–8, 2016, Orlando, FL
No abstract available (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Abstracts Source Type: research

Acknowledgment of Reviewers
No abstract available (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Acknowledgment of Reviewers Source Type: research

Evaluation of the potential antidepressant effects of soybean isoflavones
Conclusions: Although the data are inconsistent and limited, the clinical and epidemiologic evidence suggests that isoflavones may offer a safe, well-tolerated option for management of depression. Furthermore, the intervention doses used in the clinical studies fall well within the dietary range. The extant literature reveals key design features for future studies, which based upon the results of this review, are clearly warranted. (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Review Article Source Type: research

Immunizations for adult women
Abstract: Immunizations protect individual persons and contribute to public health by reducing morbidity and mortality associated with common infectious diseases. In this Practice Pearl, we review guidelines for adult immunizations and recent and potential changes in vaccines. (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research

Longitudinal assessment of marrow fat content using three-point Dixon technique in osteoporotic rabbits
Conclusions: Results of three-point Dixon technique demonstrated a very reproducible manner within and between observers and acceptable scan-rescan performance in the assessment of marrow fat in rabbits. (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Effect of the menopausal transition and physical activity energy expenditure on inflammatory markers: a MONET group study
This study aimed to investigate the impact of menopausal transition and physical activity on inflammatory makers. Methods: One hundred two healthy premenopausal women participated in a 5-year longitudinal study. The present secondary analyses were performed on 58 participants with a full set of data (age: 49.6 ± 1.7 y; body mass index: 23.3 ± 2.4 kg/m2). Measures included body composition, waist circumference, fasting glucose and insulin levels, insulin sensitivity, plasma lipid levels, cardiorespiratory fitness, physical activity energy expenditure, and inflammatory markers. Results: Repeated m...
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Understanding women's experience of memory over the menopausal transition: subjective and objective memory in pre-, peri-, and postmenopausal women
This study aimed to examine women's subjective perception of memory and their objective memory performance across the menopausal transition. Methods: One hundred thirty women, aged 40 to 60 years were recruited from outpatient Menopause and Gynaecological clinics at the Royal Women's Hospital, Melbourne. Women were divided into menopausal stage groups according to the Stages of Reproductive Aging Workshop criteria based on menstrual patterns. All women completed self-report measures of depressive, anxiety, vasomotor, and sleep symptoms; attitude to menopause; and various aspects of memory, including memory contentment, fr...
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Effectiveness and cost-effectiveness of pessary treatment compared with pelvic floor muscle training in older women with pelvic organ prolapse: 2-year follow-up of a randomized controlled trial in primary care
Conclusions: In older women with symptomatic prolapse, there was no significant difference between pessary treatment and PFMT in reducing pelvic floor symptoms, but specific prolapse-related symptoms did improve more with pessary treatment. Pessary treatment was preferable in the cost-effectiveness analysis. When counseling women for prolapse treatment it should, however, be taken into account that pessary fitting fails in a considerable portion of women and that pessary treatment was associated with more side effects compared with PFMT. (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Hormonal influence on the effect of mirabegron treatment for overactive bladder
Conclusions: Estradiol, gonadotropic hormones, thyroid hormones, and testosterone levels did not influence the clinical effects of mirabegron in women with overactive bladder. Menopause status should not be a determinant for mirabegron treatment. (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Associations between dietary patterns and psychological factors: a cross-sectional study among Chinese postmenopausal women
Conclusions: Dietary patterns featuring a low intake of processed foods and/or a high intake of whole plant foods were associated with a reduced risk of depression and perceived stress. (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Depressive symptoms across the menopause transition: findings from a large population-based cohort study
Conclusions: Depressive symptoms follow distinct trajectories across the menopause transition. Most women have stable symptoms, but around 9% have increasing symptoms and a similar proportion (8.5%) decreasing symptoms. Increasing depressive symptoms were independent of vasomotor symptoms but were associated with oophorectomy and stopping or starting hormone therapy. A large number of women were excluded due to missing data, and thus the results should be interpreted with caution. (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Calcium plus vitamin D supplementation and height loss: findings from the Women's Health Initiative Calcium and Vitamin D clinical trial
Objective: The aim of this study was to determine the associations between calcium + vitamin D supplementation (vs placebo) and height loss in 36,282 participants of the Women's Health Initiative Calcium and Vitamin D trial. Methods: Post hoc analysis of data from a double-blind randomized controlled trial of 1,000 mg of elemental calcium as calcium carbonate with 400 IU of vitamin D3 daily (CaD) or placebo in postmenopausal women at 40 US clinical centers. Height was measured annually (mean follow-up 5.9 y) with a stadiometer. Results: Average height loss was 1.28 mm/y among participants assigned to CaD versus 1.26 mm/y...
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Learning more about food, mental health, and menopause
No abstract available (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Editorials Source Type: research

Menopause and depression: keep your eye on the long run
No abstract available (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Editorials Source Type: research

Calcium and vitamin D supplementation for fracture prevention in postmenopausal women: where does the evidence lead?
No abstract available (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Editorials Source Type: research

Marla Shapiro, CM, MDCM, CCFP, MHSc, FRCPC, FCFP, NCMP 2016-2017 NAMS President
No abstract available (Source: Menopause)
Source: Menopause - November 23, 2016 Category: OBGYN Tags: Editorials Source Type: research

Anxiogenic CO2 stimulus elicits exacerbated hot flash-like responses in a rat menopause model and hot flashes in postmenopausal women
Conclusions: The studies demonstrate that this anxiogenic stimulus is capable of inducing cutaneous vasomotor responses in OVEX rats, and eliciting hot flashes in postmenopausal women. In rats, the severity of the response was mediated by loss of ovarian function and increased anxiety traits (SERT+/−), and, in women, by daily hot flash frequency. These findings may provide insights into anxiety-related triggers and genetic risk factors for hot flashes in thermoneutral environments. (Source: Menopause)
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women: a randomized, double-blinded, placebo-controlled trial
The objective of this study was to evaluate the efficacy of Tribulus terrestris for the treatment of hypoactive sexual desire disorder in postmenopausal women and evaluate its effect on the serum levels of testosterone. Methods: We performed a prospective randomized, double-blinded, placebo-controlled study, during 18 months. A total of 45 healthy sexually active postmenopausal women reporting diminished libido were selected to participate in the study and were randomly assigned to receive 750 mg/d of T terrestris or placebo for 120 days. Randomization was performed using sealed envelopes. All participants answered the ...
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Low AMH levels as a marker of reduced ovarian reserve in young women affected by Down's syndrome
Objective: Women with Down's syndrome (DS) experience menopause earlier than healthy women and are twice as likely to undergo premature ovarian insufficiency. Menopause accelerates cognitive decline and is associated with a twofold increased mortality risk in DS women. Nonetheless, no previous studies investigated the ovarian reserve in this population. The aim of the present study was to evaluate the circulating antimullerian hormone (AMH) levels in DS women with regular menstrual cycles, in comparison with those observed in an age-matched group of healthy women. Methods: Fourteen women with DS and 20 normo-ovulatory vol...
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Menopause is associated with articular cartilage degeneration: a clinical study of knee joint in 860 women
Objective: The purpose of this study was to investigate the association between menopause and severity of knee joint cartilage degeneration using a magnetic resonance imaging-based six-level grading system, with six cartilage surfaces, the medial and lateral femoral condyle, the femoral trochlea, the medial and lateral tibia plateau, and the patella. Methods: The study cohort comprised 860 healthy women (age 36-83 y), and 5,160 cartilage surfaces were analyzed. Age, weight, height, age at natural menopause, and years since menopause (YSM) were obtained. Cartilage degeneration was assessed using a magnetic resonance imagin...
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

In-hospital complications of vaginal versus laparoscopic-assisted benign hysterectomy among older women: a propensity score-matched cohort study
Conclusions: Advanced age alone should not be the limiting factor for surgical referral of laparoscopic hysterectomy. The shorter hospital stay and low in-hospital complications associated with laparoscopic, as opposed to vaginal hysterectomies, are important attributes of a surgical procedure essential to the postoperative care in older women aged 65 years or more. (Source: Menopause)
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Bone loss after oophorectomy among high-risk women: an NRG oncology/gynecologic oncology group study
Conclusions: These results demonstrate that premenopausal women undergoing oophorectomy clearly experience bone loss, an adverse effect of oophorectomy, which requires attention and active management. BMD should be monitored postoophorectomy, and treated per standard practice guidelines. Future studies will be required to determine if early treatment can mitigate fracture risk, and to test promising therapeutic interventions and novel prevention strategies, such as increased physical activity or alternative medications, in randomized trials. (Source: Menopause)
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Measuring hot flash phenomenonology using ambulatory prospective digital diaries
Conclusions: A prospective electronic digital hot flash diary allows for a more precise quantitation of hot flashes while overcoming many of the limitations of commonly used retrospective questionnaires and paper diaries. Unique insights into the phenomenology, loci, and associated characteristics of hot flashes were obtained using this device. The digital hot flash phenomenology diary is recommended for future ambulatory studies of hot flashes as a prospective measure of the hot flash experience. (Source: Menopause)
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Extended-release oxybutynin therapy for vasomotor symptoms in women: a randomized clinical trial
Conclusions: Oxybutynin is an effective, nonhormonal therapy for moderate-to-severe vasomotor symptoms in postmenopausal women. (Source: Menopause)
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Timing and persistence of effect of conjugated estrogens/bazedoxifene in postmenopausal women
Objective: The aim of the study was to determine the time course of effect with conjugated estrogens/bazedoxifene (CE/BZA) in nonhysterectomized postmenopausal women in five phase 3 trials. Methods: This post hoc analysis identified when CE 0.45 mg/BZA 20 mg and CE 0.625 mg/BZA 20 mg first achieved a statistically significant difference (P  (Source: Menopause)
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Reduced risk of breast cancer mortality in women using postmenopausal hormone therapy: a Finnish nationwide comparative study
Conclusions: In the Finnish unselected population, breast cancer is fatal in 1 of 10 patients. Our data imply that this risk is prevalent in 1 of 20 patients with history of HT use. This is an important message for women considering or already using HT. (Source: Menopause)
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Cardiovascular, hemodynamic, neuroendocrine, and inflammatory markers in women with and without vasomotor symptoms
Conclusions: Self-reported VMS bother is associated with an unfavorable hemodynamic and neuroendocrine profile characterized by increased hypothalamic-pituitary-adrenal axis and central sympathetic activation, inflammation, and vasoconstriction. Further research investigating this profile in relation to VMS, and the potential health implications of this association, is warranted. (Source: Menopause)
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Age at menarche, androgen concentrations, and midlife obesity: findings from the Midlife Women's Health Study
Conclusions: The results of this study indicate that age at menarche is associated with midlife obesity independent of free testosterone concentrations measured in adulthood. (Source: Menopause)
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Anthropometric and cardiovascular responses to hypertrophic resistance training in postmenopausal women
Objective: Menopause induces a phase of decreased physical fitness and altered body composition characterized by increased total and abdominal fat and reduced lean mass. It is, however, inconclusive which specific resistance training (RT) subtypes can reverse these deleterious changes in postmenopausal women. Methods: Thirty-seven postmenopausal women were randomized to a 6-week nonexercising control group (n = 18) or hypertrophic RT group (n = 19) that engaged in two 40-minute sessions weekly using three sets of 12 repetitions at 67% to 85% one-repetition maximum for 10 whole-body exercises. Results: RT signific...
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Long-term oral bisphosphonate use in relation to fracture risk in postmenopausal women with breast cancer: findings from the Women's Health Initiative
Conclusions: Bisphosphonate use of 8 or more years was associated with higher risk of any clinical fracture compared with 2 to 3 years of use. Our findings raise concern about potential harm or decreased effectiveness of long-term bisphosphonate use on fracture risk. The findings warrant confirmatory studies. (Source: Menopause)
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Mechanisms explaining effects of pubertal timing on adulthood cardio-metabolic health
No abstract available (Source: Menopause)
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Editorials Source Type: research

Resistance training improves cardiovascular health in postmenopausal women
No abstract available (Source: Menopause)
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Editorials Source Type: research

Long-term bisphosphonates: primum non nocere
No abstract available (Source: Menopause)
Source: Menopause - October 28, 2016 Category: OBGYN Tags: Editorials Source Type: research

Bone mass improved effect of icariin for postmenopausal osteoporosis in ovariectomy-induced rats: a meta-analysis and systematic review
Objective: Ovariectomy (OVX)-induced rats are the most frequently used animal model to research postmenopausal osteoporosis. Our objective was to summarize and critically assess the bone mass improved effect of icariin (ICA) for treatment of postmenopausal osteoporosis in an OVX-induced rat model. Methods: The PUBMED, EMBASE, and Chinese databases were searched from their inception date to February 2015. Two reviewers independently selected animal studies that evaluated the bone mass improved effect of ICA compared with control in OVX-induced rats. Extracted data were analyzed by RevMan statistical software, and the metho...
Source: Menopause - September 23, 2016 Category: OBGYN Tags: Review Article Source Type: research

Sexual and reproductive healthcare utilization among women aged 40 to 49 in rural China
Conclusions: Women of late reproductive age in rural China are not receiving as regular care as younger women. This study identifies sociodemographic and health service correlates for service-seeking behavior, many of which are modifiable. Health services should pay greater attention to this group, including community-based efforts to encourage routine examinations and appropriate use of health services. (Source: Menopause)
Source: Menopause - September 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Prevalence and association between objective signs and subjective symptoms of vaginal atrophy: the AGATA study
Conclusions: The results show that objective signs and subjective symptoms of VA have a different prevalence distribution in the years after menopause and are not strictly associated. (Source: Menopause)
Source: Menopause - September 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Age at natural menopause in women on long-term methotrexate therapy for rheumatoid arthritis
Objective: The aim of the study was to compare the natural menopause ages of healthy women with those of women with methotrexate (MTX)-treated rheumatoid arthritis (RA), and to specifically assess the effect of disease onset and activity and the use of MTX on the age of the last menstruation. Methods: We performed a retrospective review of medical records to identify the ages at which menopause occurred in women with premenopausal RA treated with MTX and in women with postmenopausal onset, irrespective of therapy. Natural menopause ages were also compared between participants with and without RA. Results: Women with prem...
Source: Menopause - September 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Physical fitness improvement in overweight postmenopausal women who do not lose fat mass in response to exercise training
Objective: The aim of this study was to examine if overweight postmenopausal women who do not experience fat mass loss after a 1-year aerobic exercise (AE) and resistance training (RT) program can still improve physical fitness. Methods: Thirty-one overweight women (body mass index 28-40 kg/m2 or waist circumference ≥88 cm) participated in three weekly supervised AE and RT sessions for 1 year. All women were categorized according to their fat mass changes after the intervention: 14 women were considered as responders (fat mass loss ≥5% of initial fat mass) and 17 as nonresponders (fat mass loss (Source: Menopause)
Source: Menopause - September 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Short-term effects of low-dose estradiol on endothelial function and blood viscosity in nondiabetic postmenopausal overweight women: a double-blind, placebo-controlled study
This study evaluates the short-term effects of low-dose transdermal estradiol on endothelial function, insulin sensitivity, and blood viscosity in nondiabetic overweight/obese women. Methods: Forty-four nondiabetic overweight/obese women with a history of recent menopause were randomly allocated, in a double-blind fashion, to receive transdermal estradiol (1 mg/d, n = 22) or placebo (n = 22). The following parameters were assessed: endothelial reactivity (venous occlusion plethysmography and nailfold videocapillaroscopy), plasma levels of soluble adhesion molecules, insulin sensitivity (homeostasis model assessm...
Source: Menopause - September 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Fractional microablative CO2 laser for vulvovaginal atrophy in women treated with chemotherapy and/or hormonal therapy for breast cancer: a retrospective study
Objectives: Breast cancer is one of the most common malignancies in women. Hormonal treatment and chemotherapy induce a transient or permanent menopause status. Vulvovaginal atrophy (VVA) is a frequent debilitating symptom of menopause that is best treated with local or systemic estrogen formulations. Because estrogens drive the growth of the majority of breast cancers, most effective VVA therapies are precluded. The aim of this study was to evaluate the effects of fractional microablative CO2 laser on sexual function and in relieving symptoms in women with breast cancer and VVA induced or exacerbated by iatrogenic menopau...
Source: Menopause - September 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

An assessment of the safety and efficacy of a fractional CO2 laser system for the treatment of vulvovaginal atrophy
Objectives: The aim of the study was to assess the safety and efficacy of a novel fractional CO2 laser for the treatment of genitourinary syndrome of menopause (GSM). Methods: Women presenting with GSM and meeting study criteria were enrolled. Examinations at baseline and follow-up (3 mo after final treatment) evaluated dilator tolerance and vaginal pH. Visual analog scales were used to assess pain, vaginal burning, vaginal itching, vaginal dryness, dyspareunia, and dysuria; Vaginal Health Index scores were completed before each treatment and at follow-up; Female Sexual Function Index and Short Form 12 questionnaires were...
Source: Menopause - September 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Most bothersome symptom in women with genitourinary syndrome of menopause as a moderator of treatment effects
Conclusions: The approved dose of CE/BZA had clear benefits, particularly in women with pain with intercourse (the most common bothersome symptom), in whom it improved lubrication, superficial cell counts, and sexual functioning. (Source: Menopause)
Source: Menopause - September 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Effect of conjugated estrogens/bazedoxifene on postmenopausal bone loss: pooled analysis of two randomized trials
Objective: Conjugated estrogens/bazedoxifene reduces vasomotor symptoms and prevents postmenopausal bone loss without stimulating the breast and endometrium. We analyzed changes in bone mineral density (BMD) and bone markers using pooled data from two phase-3 trials. Methods: Selective Estrogens, Menopause, and Response to Therapy (SMART)-1 and SMART-5 were randomized, double-blind, placebo- and active-controlled studies conducted in postmenopausal nonhysterectomized women. BMD and turnover marker data were pooled for women given conjugated estrogens (0.45 or 0.625 mg) plus bazedoxifene 20 mg or placebo over 12 months. Se...
Source: Menopause - September 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Prescribing of FDA-approved and compounded hormone therapy differs by specialty
Conclusions: Although all physician specialties surveyed prescribed HT, differences in prescribing CHT versus FDA-approved formulations by medical specialty/practice seemed to exist. Of those surveyed, OB/GYNs and GPs prescribed proportionally more FDA-approved HT, whereas WPs, similarly, prescribed more CHT. More discussion is needed concerning physicians’ decisions to prescribe CHT versus FDA-approved formulations. (Source: Menopause)
Source: Menopause - September 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Characterizing the trajectories of vasomotor symptoms across the menopausal transition
Conclusions: These data distinctly demonstrate heterogeneous patterns of menopausal symptoms that are associated with race/ethnicity, reproductive hormones, premenopause body mass index, and psychosocial characteristics. Early targeted intervention may have a meaningful impact on long-term VMS. (Source: Menopause)
Source: Menopause - September 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research

Relationship between changes in vasomotor symptoms and changes in menopause-specific quality of life and sleep parameters
Conclusions: Frequency and severity of HFs have an approximately linear relationship with MSQOL and sleep parameters—that is, improvements in HFs are associated with improvements in MSQOL and sleep. Such relationships may enable clinicians to predict changes in sleep and MSQOL expected from various VMS treatments. (Source: Menopause)
Source: Menopause - September 23, 2016 Category: OBGYN Tags: Original Articles Source Type: research