Reproductive period and preclinical cerebrospinal fluid markers for Alzheimer disease: a 25-year study
Conclusions:
Our findings suggest that longer exposure to endogenous estrogen may be associated with increased levels of AD biomarkers in the preclinical phase of AD. These findings, however, need to be confirmed in larger samples.
Video Summary:http://links.lww.com/MENO/A804. (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research
Obesity increases endometrial cancer risk in Chinese women with postmenopausal bleeding
We examined the relationship between body mass index (BMI) at referral and subsequent diagnosis of endometrial cancer in a cohort of Chinese women presenting with postmenopausal bleeding, to determine whether BMI of 25 kg/m2 would serve to delineate women at increased risk of endometrial cancer.
Methods:
This cohort included 4,164 Chinese women referred for postmenopausal bleeding from 2002 to 2013. For all women, a medical history was taken, and physical examination, BMI measurement, transvaginal pelvic ultrasonography, and endometrial sampling were performed. Additional investigations were performed as indicated...
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research
Impact of menopausal status on risk of metastatic recurrence of breast cancer
Conclusions:
Women with earlier age at menopause, and ER+ and/or PR+ stage I-III breast cancer were more likely to develop metastatic breast cancer. Age increased the risk of metastatic relapse for women with ER− and PR− disease, but not for ER+ and/or PR+ cancers. (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research
Reproductive aging and Alzheimer disease biomarkers: an evolving field
No abstract available (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Editorials Source Type: research
Is obesity predictive of endometrial cancer for women with postmenopausal bleeding?
No abstract available (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Editorials Source Type: research
Menopausal status at diagnosis of breast cancer and risk of metastatic recurrence
No abstract available (Source: Menopause)
Source: Menopause - October 1, 2021 Category: OBGYN Tags: Editorials Source Type: research
Preeclampsia and cancer risk in women in later life: a systematic review and meta-analysis of cohort studies
Conclusions and Relevance:
Overall, women with preeclampsia have a decreased BC risk and increased ovarian cancer risk compared with the normal population. A subgroup analysis stratified by reproductive factors demonstrated that BC risk decreased in the preeclampsia population in parous women, women with full-term pregnancies, and women with increasing parity regardless of their menopausal status and the sex of their offspring. (Source: Menopause)
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Review Article Source Type: research
Statin therapy in midlife women
The menopause transition is associated with adverse changes to the lipid profile. Although there are no specific treatment guidelines for women, current evidence supports the use of statin therapy in women with 1) established clinical atherosclerotic cardiovascular disease (ASCVD); 2) primary hypercholesterolemia, with low-density lipoprotein cholesterol of 190 mg/dL (4.9 mmol/L) or higher; 3) diabetes mellitus regardless of ASCVD risk category (ages 40-75 y); and 4) for primary prevention of ASCVD in women at high risk (10-y risk, ≥20%) or intermediate risk (10-y risk, ≥7.5-20%) with the presence of guideline-deri...
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research
Preparing women experiencing symptoms of menopause for shared decision making about treatment
Objective:
To develop a decision support intervention that can be used with women experiencing menopausal symptoms to facilitate treatment shared decision making.
Methods:
Our research team contacted patients with reported menopausal symptoms by telephone to obtain consent and administer a baseline survey. Subsequently, we sent participants a booklet on the treatment of menopausal symptoms. A nurse educator then contacted participants by telephone to review the booklet and guide them through a structured decision counseling exercise designed to help clarify treatment preference. A 60-day endpoint telephone surve...
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research
Is climacterium by the mid-40s associated with thyroid dysfunction or autoimmunity? A population-based study
Objective:
We investigated whether more advanced climacteric stage in the mid-40s is associated with thyroid autoimmunity and dysfunction.
Methods:
This cross-sectional cohort study included 2,569 46-year-old women. Thyroid hormone, thyroid peroxidase antibodies, and follicle-stimulating hormone levels were determined. Using menstrual history and follicle-stimulating hormone levels, the participants were divided into climacteric (n = 340) and preclimacteric (n = 2,229) groups. Women diagnosed with premature ovarian insufficiency (menopause by 40 y of age) were excluded. The use of thyroid medication wa...
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research
Effects of oral versus transdermal estradiol plus micronized progesterone on thyroid hormones, hepatic proteins, lipids, and quality of life in menopausal women with hypothyroidism: a clinical trial
Objective:
The aim of the study was to evaluate the effects of usual doses of oral estradiol with transdermal estradiol and the effects of these estrogens plus micronized progesterone (MP) in menopausal women with primary hypothyroidism.
Methods:
Twenty women were randomized to 12 weeks of treatment with estradiol 1 mg tablets or estradiol 1 mg gel. Then, women with a uterus received a 100 mg capsule of oral MP. Thyroid function, thyroxine-binding globulin (TBG), sex hormone-binding globulin (SHBG), insulin-like growth factor 1 (IGF-1), lipid profiles, and quality of life were measured at baseline and af...
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research
Differences in menopausal symptoms and female sexual function by region and ethnicity in West Texas and Central Arizona: a cross-sectional survey
Objective:
To evaluate menopausal symptoms and sexual problems in Hispanic and non-Hispanic women in two Southwest areas.
Methods:
An anonymous survey including the Green Climacteric Scale (GCS), Female Sexual Function Index (FSFI), and demographics was distributed to English and Spanish-speaking women age 40 to 60 in Scottsdale, Arizona, and West Texas. FSFI for sexually active women and GCS scores for the Hispanic and non-Hispanic women in Texas were analyzed with multivariable analysis and compared between Texas and Arizona for Non-Hispanic participants.
Results:
Predominantly non-Hispanic women (70%),...
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research
Risk of de novo severe carpal tunnel syndrome after bilateral oophorectomy: a population-based cohort study
Conclusions:
The risk of severe CTS, common in perimenopausal women, is increased after bilateral oophorectomy. The association may be causal or due to confounding. Therefore, the precise biological mechanisms explaining the association and the absence of a mitigating effect of estrogen therapy should be further investigated. (Source: Menopause)
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research
Symptom experience during the late reproductive stage and the menopausal transition: observations from the Women Living Better survey
Conclusions:
Women in the LRS experience symptoms strikingly similar to those often associated with the MT. Women do not expect these changes until the age of 50 years or later and are surprised by such symptoms before cycle irregularity. Research about the epidemiology and management of LRS symptoms, anticipatory guidance for women, and education for clinicians who care for them warrant increased attention. (Source: Menopause)
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research
The role of multiparity and maternal age at first pregnancy in the association between early menarche and metabolic syndrome among middle-aged and older women
Conclusions:
Age at first pregnancy may partially contribute to the association between early menarche and metabolic syndrome among middle-aged and older women who had experienced a pregnancy over their lifetime. (Source: Menopause)
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research
