Application of the 21-item Vulvovaginal Symptoms Questionnaire in postmenopausal Spanish women
Conclusions: Internal consistency of the VSQ and the ICIQ-SF was good in this postmenopausal sample in which age, sexual activity, urinary incontinence, drug use, and other personal aspects were important covariates determining the severity of vulvovaginal symptoms. (Source: Menopause)
Source: Menopause - October 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Association of visceral fat area with the presence of depressive symptoms in Chinese postmenopausal women with normal glucose tolerance
Conclusions: In Chinese postmenopausal women, visceral fat accumulation was an independent and positive factor significantly associated with the presence of depressive symptoms. (Source: Menopause)
Source: Menopause - October 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Evaluation of depressive symptoms in mid-aged women: report of a multicenter South American study
Conclusion: In this mid-aged female South American sample, depressive symptoms correlated to menopausal status and related aspects, ethnicity, and personal and partner issues. All these features require further research. (Source: Menopause)
Source: Menopause - October 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Successful use of the Gellhorn pessary as a second-line pessary in women with advanced pelvic organ prolapse
Objective: The primary outcome of this study was the efficacy of the Gellhorn pessary in patients with advanced pelvic organ prolapse (POP) who failed to retain a ring with support pessary, and the secondary outcome is the related factors that influence its successful use. Methods: Between May 2015 and May 2016, women with POP quantification stage III to IV, who initially failed to place a ring with a support pessary, but were then successfully fitted with a Gellhorn pessary, were included. We performed independent-sample t tests, nonparametric tests, chi-square tests, and logistic regressions for data analysis. Results:...
Source: Menopause - October 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

The association of surgical versus natural menopause with future left ventricular structure and function: The Coronary Artery Risk Development in Young Adults (CARDIA) Study
Conclusion: In this study, the adverse LV structure and function observed among women with SM compared with NM were explained by their unfavorable presurgical CVDRF profiles, suggesting that premenopausal CVDRF rather than gynecologic surgery predispose SM women to elevated future cardiovascular disease risk. (Source: Menopause)
Source: Menopause - October 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Circulating osteoprotegerin in postmenopausal osteoporotic women: marker of impaired glucose regulation or impaired bone metabolism
Objective: Osteoprotegerin (OPG) is closely related to insulin resistance and bone remodeling. However, no studies have examined the role of OPG in postmenopausal women with coexistent impaired glucose and bone regulation. The present study investigated the relationship of OPG to glucose homeostasis and insulin resistance in postmenopausal osteoporotic women with different types of glucose tolerance. Methods: In all, 114 postmenopausal osteoporotic women were divided into three groups according to glucose tolerance status: 51 with normal glucose tolerance (NGT, group 1), 31 with impaired glucose tolerance (IGT, group 2), ...
Source: Menopause - October 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

The impact of Fiera, a women's personal care device, on genital engorgement as measured by thermography: a proof-of-principle study
Conclusions: Use of Fiera produced statistically significant increases in the temperature of the external genitalia, markers of vasoengorgement, in both the premenopausal and postmenopausal participants. The onset of genital sexual arousal was rapid in both groups, and responsive sexual desire was experienced by all of the participants. (Source: Menopause)
Source: Menopause - October 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Combined data of intravaginal prasterone against vulvovaginal atrophy of menopause
Objective: To analyze the effects of intravaginal prasterone obtained in the three randomized clinical studies performed in postmenopausal women suffering from moderate to severe (MS) dyspareunia due to vulvovaginal atrophy (VVA). Methods: In three independent 12-week prospective, randomized, double-blind, and placebo-controlled clinical studies, the effect of daily intravaginal 0.50% (6.5 mg) prasterone was examined on four co-primary objectives in women having MS pain during sexual activity (dyspareunia), identified as their most bothersome symptom (MBS) of VVA at baseline. Results: In 436 women treated with 0.50% pras...
Source: Menopause - October 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Menopausal transition in Southern Europe: comparative study of women in Serbia and Portugal
Objective: The aim of this study was to assess and compare general menopausal quality of life in Serbia and Portugal. Methods: In all, 1,503 women aged between 40 and 65 years from Belgrade, Serbia, and Lisbon, Portugal, were included in the study. A sociodemographic questionnaire and the Utian Quality of Life (UQOL) scale were used in data collection. Results: The average age of women was 50 (SD = 5.61) years. Serbian and Portuguese women differed in all sociodemographic characteristics except for body mass index (BMI) and relationship status. There were no significant differences in UQOL total score (P = 0.629)...
Source: Menopause - October 28, 2017 Category: OBGYN Tags: Original Articles Source Type: research

NAMS 3rd Utian Translational Science Symposium, October 2016, Orlando, Florida A conversation about hormone therapy: is there an appropriate dose, route, and duration of use?
This report is a record of the proceedings of that symposium. The maxim about HT for the past 15 years since the publication of the initial results of the Women's Health Initiative (WHI) has been to prescribe the “lowest dose for the shortest period of time.” With new clinical trials, observational data, and further analysis of the WHI and the cumulative 13 years’ follow-up, it was time to hold a conversation about the state of the evidence and recommendations for HT dose, route, and duration of use. The symposium brought together experts in the field of HT to speak on these topics, organized by session...
Source: Menopause - October 28, 2017 Category: OBGYN Tags: NAMS Translational Science Symposium Report Source Type: research

Dehydroepiandrosterone use in postmenopausal women: an androgenic option for managing sexual pain caused by vulvovaginal atrophy
No abstract available (Source: Menopause)
Source: Menopause - October 28, 2017 Category: OBGYN Tags: Editorials Source Type: research

Quality of life among midlife women: globalization and women's lives
No abstract available (Source: Menopause)
Source: Menopause - October 28, 2017 Category: OBGYN Tags: Editorials Source Type: research

A systematic review of the exercise effect on bone health: the importance of assessing mechanical loading in perimenopausal and postmenopausal women
Conclusions: While training effects must be interpreted with caution because of the heterogeneity of the protocols and exercises performed, this systematic review confirmed the effectiveness of impact exercises combined with other forms of training (vibration or strength training) to preserve BMD in perimenopausal and postmenopausal women. Despite the results possibly not representing a general dose-response relationship, we highlight the importance of quantifying loading intensity and frequency by means of accelerometry as these parameters are determinants for bone adaptation. (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Review Article Source Type: research

Prevalence, severity, and associated factors of menopausal symptoms in middle-aged Chinese women: a community-based cross-sectional study in southeast China
Objective: The aim of the study was to specify the prevalence and severity of menopausal symptoms, and to investigate associated factors in Chinese middle-aged women. Methods: A cross-sectional, community-based study was carried out involving 1,054 participants aged 40 to 60 years in Gongshu District, Hangzhou, Zhejiang, PR China. The presence and severity of symptoms were evaluated by having the participants complete a modified Kupperman Menopausal Index questionnaire. Serum levels of follicle-stimulating hormone and estradiol were measured. Physical and sociodemographic characteristics including height, weight, educatio...
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Depressive symptoms and weight in midlife women: the role of stress eating and menopause status
Conclusions: Both stress eating and menopause status significantly contributed to the depressive symptom—weight association. Psychosocial factors play an important role in the association between depressive symptoms and weight, and the results highlight the need to focus on both behavioral factors, and also menopause status, when identifying who is at risk for the development of poor weight outcomes. (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Pelvic organ prolapse: does hormone therapy use matter?
Conclusion: HT may have a minor negative effect on pelvic organ support; however, the effect is likely too small to be clinically relevant. (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Long-term sertraline treatment and depression effects on carotid artery atherosclerosis in premenopausal female primates
Conclusions: These findings suggest that chronic SSRI treatment is associated with the progression of carotid artery atherosclerosis, which may increase the risk for future vascular events, particularly in depressed women. The underlying mechanism remains to be determined, but does not appear to be related to SSRI effects on traditional cardiovascular risk factors. (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Ospemifene's effects on lipids and coagulation factors: a post hoc analysis of phase 2 and 3 clinical trial data
Objective: To evaluate the effect of ospemifene 60 mg on the lipid and coagulation parameters of postmenopausal women using data from five phase 2 and 3 clinical trials. Methods: Data for lipids and coagulation factors for 2,166 postmenopausal women were pooled from five randomized, placebo-controlled studies. Lipid and coagulation parameters included in this analysis were total cholesterol, high-density lipoproteins (HDL), low-density lipoproteins (LDL), triglycerides, activated partial thromboplastin time (aPTT), fibrinogen, antithrombin antigen, protein C Ag, and protein S Ag free. Results: Mean percent changes in H...
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Vaginal microbiota and genitourinary menopausal symptoms: a cross-sectional analysis
Conclusions: Presence of Lactobacillus-dominant vaginal microbiota was not associated with fewer vulvovaginal symptoms. Serum estrone was higher in women with Lactobacillus dominance, but vaginal-free glycogen was not associated with composition of the vaginal microbiota. (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Topical, geospatial, and temporal diffusion of the 2015 North American Menopause Society position statement on nonhormonal management of vasomotor symptoms
Conclusions: The findings of this study may be useful for directing the development and dissemination of future North American Menopause Society position statements and/or press releases. (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Comparison of clinical outcomes among users of oral and transdermal estrogen therapy in the Women's Health Initiative Observational Study
Conclusions: The summary index of risks versus benefits was similar for oral CEE versus oral or transdermal E2-containing regimens. CEE + P containing less than 0.625 mg/d of CEE (vs 0.625 mg/d) for less than 5 years appeared safer. (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Association between menopause and lumbar disc degeneration: an MRI study of 1,566 women and 1,382 men
This study cohort comprised of 1,566 women and 1,382 age-matched men who were admitted for low back pain from June 2013 to October 2016. Data on age, weight, height, body mass index, age at natural menopause, and years since menopause (YSM) were obtained. Lumbar disc degeneration was assessed using a magnetic resonance imaging-based eight-level grading system. Results: After adjustment for the confounding factors of age, height, and weight, young age-matched men were more susceptible to disc degeneration than premenopausal women (P  (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Promotion and marketing of bioidentical hormone therapy on the internet: a content analysis of websites
Conclusions: Claims made about BHT on the internet are misleading and not consistent with current professional organizations’ recommendations. Understanding how BHT may be promoted on the internet can help healthcare professionals when educating patients. (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Transcranial direct current stimulation effects on menopausal vasomotor symptoms
Conclusions: Our results suggest that the tDCS technique showed small trends on postmenopausal vasomotor symptoms, justifying searches for more effective methods by which tDCS could reduce hot flashes. (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Menopause and the intervertebral disc
No abstract available (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Editorials Source Type: research

What you don’t know can hurt you: more information and communication are needed regarding menopausal therapies
No abstract available (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Editorials Source Type: research

The time has come for a safe, effective way to relieve menopausal symptoms
No abstract available (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Editorials Source Type: research

Menopausal hormone therapy for primary prevention: why the USPSTF is wrong
No abstract available (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Editorials Source Type: research

Please don’t give hormone therapy a D recommendation or state that “harms far outweigh benefits for prevention of chronic disease”
No abstract available (Source: Menopause)
Source: Menopause - September 23, 2017 Category: OBGYN Tags: Editorials Source Type: research

A theory of eu-estrogenemia: a unifying concept
Conclusions: The theory of eu-estrogenemia provides a robust framework to unify the timing hypothesis, critical window theory, randomized controlled trials, the basic science of estrogen receptors, and clinical observations of patients over the past five decades. (Source: Menopause)
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Personal Perspective Source Type: research

Estriol: emerging clinical benefits
Conclusions: We conclude transvaginal estriol potentially offers a suitable physiologic delivery and cost-effective alternative to currently available estrogen regimens in selected patients. Additional studies on mode of delivery, safety, and efficacy merit further investigation. (Source: Menopause)
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Review Article Source Type: research

Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model
Conclusions: F deltoidea leaf extract mitigated postmenopausal osteoarthritic joint destruction by inhibiting inflammation and cartilage degradation enzymes, at an effective extract dose equivalent to about 60 mg/kg for humans. The main bioactive compounds are probably the antioxidative flavonoids vitexin and isovitexin. (Source: Menopause)
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Does obesity increase the risk of hot flashes among midlife women?: a population-based study
Objective: To evaluate the association between vasomotor symptoms and obesity in climacteric women. Methods: We conducted a cross-sectional population-based study of 749 women aged 45 to 60 years. The dependent variable was intensity of menopausal symptoms evaluated by the menopause rating scale questionnaire. Independent variables were sociodemographic and clinical characteristics, and obesity evaluated by body mass index. Results: There was no significant difference in the majority of clinical and sociodemographic characteristics between the body mass index groups. Obese women had less physical activity (P = 0.019)...
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Cytokine profiles in osteoporosis suggest a proresorptive bias
Conclusions: Women with low BMD have a proresorptive cytokine bias. (Source: Menopause)
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Menopause and postmenopausal hormone therapy and risk of hearing loss
Objective: Menopause may be a risk factor for hearing loss, and postmenopausal hormone therapy (HT) has been proposed to slow hearing decline; however, there are no large prospective studies. We prospectively examined the independent relations between menopause and postmenopausal HT and risk of self-reported hearing loss. Methods: Prospective cohort study among 80,972 women in the Nurses’ Health Study II, baseline age 27 to 44 years, followed from 1991 to 2013. Baseline and updated information was obtained from detailed validated biennial questionnaires. Cox proportional-hazards regression models were used to examin...
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Associations between postmenopausal endogenous sex hormones and C-reactive protein: a clearer picture with regional adiposity adjustment?
Conclusions: Prospective and systems epidemiological studies are needed to understand whether or not the cross-sectional associations we observed, independent of adiposity, between CRP-SHBG, CRP-total testosterone, and CRP-free estradiol, are causal. (Source: Menopause)
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Efficacy and safety of bazedoxifene in postmenopausal Latino women with osteoporosis
This report evaluates safety and efficacy of BZA in Latin American women in the global trial. Methods: In the 3-year, phase 3, randomized, double-blind trial, postmenopausal women with osteoporosis (N = 7,492) received BZA 20 or 40 mg/d, raloxifene 60 mg/d, or placebo. Outcomes included vertebral fractures, bone mineral density, bone turnover markers, and safety. This post hoc analysis included 3,036 Latin American women. Results: Incidence of vertebral fractures at month 36 with BZA 20 mg, BZA 40 mg, raloxifene, and placebo was 1.87%, 1.90%, 1.43%, and 2.83%, respectively (differences not significant). Adjus...
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Different features of the histopathological subtypes of ovarian tumors in pre- and postmenopausal women
Objective: To date, epidemiological evidence has consistently supported a link between ovarian cancer risk and menopause. However, little is known about how menopause status affects the risk of specific histological subtypes of ovarian tumors. We aimed to analyze the differences in various histopathological subtypes of ovarian tumors between pre- and postmenopausal women. Methods: We reviewed the medical records of women who underwent surgery for ovarian tumors and received histopathological confirmation at the Busan Paik Hospital between January 1997 and October 2016. Pathological findings were regrouped according to 201...
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Associations between high-risk alcohol consumption and sarcopenia among postmenopausal women
Conclusions: High-risk alcohol drinking was associated with a higher risk of sarcopenia in postmenopausal Korean women. (Source: Menopause)
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Effect of Foeniculum vulgare Mill. (fennel) on menopausal symptoms in postmenopausal women: a randomized, triple-blind, placebo-controlled trial
Objective: Preliminary data suggest that Foeniculum vulgare (fennel) can be an effective treatment for menopausal symptoms. This trial was designed to assess the efficacy of fennel in the management of menopausal symptoms in postmenopausal women. Methods: In this triple-blind, placebo-controlled trial, 90 postmenopausal women aged 45 to 60 years in Tehran were randomly assigned to treatment (n = 45) or placebo (n = 45) groups. The participants received 8 weeks of treatment with soft capsules containing 100 mg fennel or a placebo (2 per day for each group). The participants were followed for 2 weeks postintervent...
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Time to transient and stable reductions in hot flush frequency in postmenopausal women using conjugated estrogens/bazedoxifene
Conclusions: Although not all women using conjugated estrogens/bazedoxifene achieve permanent elimination of hot flushes, the frequency is likely to be substantially reduced during the first week to month. Women can expect approximately 50% reduction in hot flush frequency after about 8 to 10 days, and sustained improvement with continued treatment. (Source: Menopause)
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Visual improvements in vaginal mucosa correlate with symptoms of VVA: data from a double-blind, placebo-controlled trial
Objective: To evaluate the response of the vaginal mucosa with TX-004HR and its correlation with vulvar and vaginal atrophy (VVA) symptoms, and whether visual examination is a useful measure for assessing VVA. Methods: REJOICE was a 12-week, phase 3, multicenter, randomized, double-blind, placebo-controlled study of a vaginal, muco-adhesive, 17β-estradiol softgel capsule (TX-004HR 4, 10, and 25 μg) in postmenopausal women with VVA and moderate-to-severe dyspareunia. Treatments were self-administered vaginally once per day for 2 weeks, then twice per week for 10 weeks. The vagina was visually examined at baseline...
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Timing of first childbirth and age-related cataract
Conclusions: Later age of first childbirth was independently associated with higher risks of nuclear and cortical cataract in postmenopausal women. Further prospective studies are needed to elucidate the role of age at first childbirth in developing age-related cataract. (Source: Menopause)
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Does having children earlier help you see things more clearly?
No abstract available (Source: Menopause)
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Editorials Source Type: research

Changing the conversation about hormone therapy
No abstract available (Source: Menopause)
Source: Menopause - August 26, 2017 Category: OBGYN Tags: Editorials Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - July 27, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - July 27, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

Acupuncture for menopausal hot flashes: clinical evidence update and its relevance to decision making
Conclusions: Acupuncture improves menopausal hot flashes compared with no treatment; however, not compared with sham acupuncture. This is also consistent with the evidence that a range of placebo interventions improve menopausal symptoms. As clinicians play a vital role in assisting evidence-informed decisions, we need to ensure women understand the evidence and can integrate it with personal preferences. Some women may choose acupuncture for hot flashes, a potentially disabling condition without long-term adverse health consequences. Yet, women should do so understanding the evidence, and its strengths and weaknesses, aro...
Source: Menopause - July 27, 2017 Category: OBGYN Tags: Review Article Source Type: research

Androgens in postmenopausal women: a review
Abstract: There is significant interest in the use of androgen therapy for postmenopausal women. This review provides background on endogenous androgens in women, describes factors that affect circulating androgen concentrations, and examines the relationship between low levels of androgens and sexual problems. Possible effects of androgens in postmenopausal women beyond sexual function also are discussed. Clinical trials of androgen therapy for the treatment of hypoactive sexual desire disorder are reviewed, with a discussion of potential risks. A practical approach to using androgens to treat low sexual desire with assoc...
Source: Menopause - July 27, 2017 Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research

Involvement of HSP70 and HO-1 in the protective effects of raloxifene on multiple organ dysfunction syndrome by endotoxemia in ovariectomized rats
Conclusions: Long-term treatment with raloxifene reduces the severity of sepsis in OVX rats, attributed from up-regulation of HSP70 and HO-1 to exert the antioxidant and anti-inflammatory capacities. These findings provide new insights into bacterial infection during menopause and the molecular mechanism of raloxifene. (Source: Menopause)
Source: Menopause - July 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research