The effect of micronized progesterone and medroxyprogesterone acetate in combination with transdermal estradiol on hemostatic biomarkers in postmenopausal women diagnosed with POI and early menopause: a randomized trial
Conclusion:
Fluctuations in traditional hemostatic biomarkers were not reproduced by parallel changes in thrombin generation parameters that remained neutral in both groups compared with baseline. The absence of statistically significant changes in thrombin generation for the first 3-months of hormone therapy use is reassuring and would suggest a neutral effect of both progestogens on the global coagulation assay. (Source: Menopause)
Source: Menopause - May 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Prognostic value of arterial stiffness in menopausal women
This study aimed to verify the prognostic value of arterial stiffness in menopausal women.
Methods:
We retrospectively analyzed 2,917 menopausal women (age>55y) without overt cardiovascular disease who underwent brachial-ankle pulse wave velocity measurement. The primary endpoint was a composite of clinical events, including all-cause death, nonfatal myocardial infarction, coronary revascularization, and stroke, hereafter referred to as major adverse cardiovascular events. Propensity score matching and inverse probability-treatment weighting analysis were used to balance differences in baseline participant character...
Source: Menopause - May 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research
The association of age at natural menopause with pre- to postmenopausal changes in left ventricular structure and function: the Coronary Artery Risk Development in Young Adults (CARDIA) study
Conclusion:
In this study, premenopausal CVD risk factors attenuated the association of ANM with changes in LV structure parameters. These data suggest that premenopausal CVD risk factors may predispose women to elevated future CVD risk more than ovarian aging. (Source: Menopause)
Source: Menopause - May 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Prevalence, severity, and associated factors in women in East Asia with moderate-to-severe vasomotor symptoms associated with menopause
Conclusions:
Vasomotor symptoms associated with menopause affected =80% of women aged 40 to 65 years. A substantial proportion of women are unsuitable for, or choose not to take, menopausal hormone therapy, resulting in an unmet need for nonhormonal treatment options. (Source: Menopause)
Source: Menopause - May 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research
The effect of music therapy on menopausal symptoms and depression: a randomized-controlled study
Conclusions:
There was a significant decrease of posttest BDI scores of the women in the music group but not in the control group. Listening to music can help reduce depression levels and symptoms of menopause in postmenopausal women. Music could be used as a nonpharmacological therapeutic option in nursing care. (Source: Menopause)
Source: Menopause - May 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research
A 16-week multicomponent exercise training program improves menopause-related symptoms in middle-aged women. The FLAMENCO project randomized control trial
Conclusions:
A 16-week multicomponent physical exercise program showed a positive effect on menopause- related symptoms especially in couple relationships, psychological state, and VMS, among 45 to 60 year old women. (Source: Menopause)
Source: Menopause - May 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Blood pressure control and glaucoma risk in postmenopausal women: an analysis from the Women's Health Initiative
Objective:
Individuals with elevated systolic blood pressure (BP) or low diastolic BP, whether or not on antihypertensive treatment, may be at higher risk for developing glaucoma. We aimed to investigate BP levels in relation to glaucoma risk in a large cohort of postmenopausal women.
Methods:
Prospective follow-up of 101,447 postmenopausal women without prior history of glaucoma enrolled in the Women's Health Initiative Study. BP was measured in-clinic at baseline and after 3 years using standardized procedures. Antihypertensive medication use was determined by drug inventory at baseline and year 3. Women sel...
Source: Menopause - May 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Avoidable bilateral salpingo-oophorectomy at hysterectomy: a large retrospective study
Objectives:
Evaluate the proportion of justified bilateral salpingo-oophorectomy (BSO) at hysterectomy, based on pathologic diagnosis, and determine prevalence of avoidable BSO based on pre- and intraoperative considerations and pathologic diagnosis.
Methods:
Retrospective review of hysterectomies at seven Ontario, Canada hospitals from 2016 to 2019. Surgeries completed by oncologists or for invasive placentation were excluded. Patient, case, and surgeon characteristics were recorded along with pathologic diagnoses. Avoidable BSO criteria were: preoperative diagnosis of cervical dysplasia or benign diagnosis oth...
Source: Menopause - May 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research
Oophorectomy and rate of dementia: a prospective cohort study
Conclusions:
Bilateral, but not unilateral, oophorectomy was associated with an increased rate of incident dementia. We were unable to establish whether this association was conditional on hysterectomy or HT use. Although an increase in dementia after bilateral oophorectomy is biologically plausible, limited statistical power hampers the precision of the estimates. (Source: Menopause)
Source: Menopause - May 1, 2022 Category: OBGYN Tags: Original Studies Source Type: research
NAMS 2021 Utian Translational Science SymposiumSeptember 2021, Washington, DCCharting the path to health in midlife and beyond: the biology and practice of wellness
Charting the Path to Health in Midlife and Beyond: The Biology and Practice of Wellness was a Translational Science Symposium held on Tuesday, September 21, 2021. Foundational psychosocial and behavioral approaches to promote healthy aging and strategies to disseminate this information were discussed. The following synopsis documents the conversation, describes the state of the science, and outlines a path forward for clinical practice. Wellness, in its broadest sense, prioritizes an orientation toward health, and an embrace of behaviors that will promote it. It involves a journey to improve and maintain physical and menta...
Source: Menopause - May 1, 2022 Category: OBGYN Tags: NAMS Utian Translational Science Symposium Report Source Type: research
When gynecologic surgery is needed, are women's ovarian function being preserved as often as it should be?
No abstract available (Source: Menopause)
Source: Menopause - May 1, 2022 Category: OBGYN Tags: Editorials Source Type: research
Contributions of oophorectomy and other gynecologic surgeries to cognitive decline and dementia
No abstract available (Source: Menopause)
Source: Menopause - May 1, 2022 Category: OBGYN Tags: Editorials Source Type: research
Letters to the editor
No abstract available (Source: Menopause)
Source: Menopause - April 1, 2022 Category: OBGYN Tags: Letter to the Editor Source Type: research
Letters to the Editor
No abstract available (Source: Menopause)
Source: Menopause - April 1, 2022 Category: OBGYN Tags: Letter to the Editor Source Type: research
Ovarian insufficiency and secondary amenorrhea in a patient with a novel variant within GDF9 gene
Conclusions:
Should the predicted elongated GDF9 protein and differentially configurated GDF9 mature protein molecule form unstable dimers, rapid proteolytic degradation may take place and inhibit homo/heterodimer formation. (Source: Menopause)
Source: Menopause - April 1, 2022 Category: OBGYN Tags: Case Report Source Type: research
