Evaluation of endometrial progesterone receptor expression after 12 weeks of exposure to a low-dose vaginal estradiol insert
Conclusions: No meaningful differences in endometrial PGR expression were observed with the vaginal E2 (4- and 10-μg) inserts at week 12 from baseline, supporting the hypothesis that local exposure to E2 from a low-dose, vaginal insert placed near the vaginal introitus will not be sufficient to upregulate endometrial PGR expression. Coupled with the lack of histologic changes and systemic absorption, our data suggest that these softgel vaginal E2 inserts would not be expected to stimulate endometrial hyperplasia leading to a potential endometrial safety issue in postmenopausal women with moderate to severe dyspareunia...
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Original Studies Source Type: research

Management of osteoporosis in postmenopausal women: the 2021 position statement of The North American Menopause Society
Conclusions: Osteoporosis is a common disorder in postmenopausal women. Management of skeletal health in postmenopausal women involves assessing risk factors for fracture, reducing modifiable risk factors through dietary and lifestyle changes, and the use of pharmacologic therapy for patients at significant risk of osteoporosis or fracture. For women with osteoporosis, lifelong management is necessary. Treatment decisions occur continuously over the lifespan of a postmenopausal woman. Decisions must be individualized and should include the patient in the process of shared decision-making. (Source: Menopause)
Source: Menopause - September 1, 2021 Category: OBGYN Tags: NAMS Position Statement Source Type: research

A path to a healthier middle age in adolescents with early menarche: avoid teen pregnancy?
No abstract available (Source: Menopause)
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Editorials Source Type: research

Initial observations describing a lack of endometrial estrogenicity in response to low-dose estrogen vaginal implants
No abstract available (Source: Menopause)
Source: Menopause - September 1, 2021 Category: OBGYN Tags: Editorials Source Type: research

Response to a letter to the editor on “HDL-C and arterial calcification in midlife women: The contribution of estradiol and C-reactive protein?”
No abstract available (Source: Menopause)
Source: Menopause - August 1, 2021 Category: OBGYN Tags: Letters to the Editor Source Type: research