Genetic variants of age at menopause are not related to timing of ovarian failure in breast cancer survivors
Conclusions: Thirteen previously identified genetic variants associated with time to natural menopause were not related to timing of ovarian failure in breast cancer survivors. (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Improving menopausal symptoms through promoting physical activity: a pilot Web-based intervention study among Asian Americans
Objective: Based on previous studies, a Web-based physical activity promotion program with educational modules on menopausal symptoms and physical activity has been developed for Asian American midlife women to reduce their menopausal symptoms through increasing their physical activity. The purpose of this pilot randomized intervention study was to determine the efficacy of the Web-based program in improving menopausal symptom experience of Asian American midlife women. Methods: This was a randomized repeated measures pretest/posttest (pretest, post 1 month, and post 3 months) control group study among 29 Asian American m...
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Association between anxiety and severe quality-of-life impairment in postmenopausal women: analysis of a multicenter Latin American cross-sectional study
Conclusions: In this postmenopausal Latin American sample, anxiety was independently associated with severe QoL impairment. Hence, screening for anxiety in this population is important. (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Free androgen index as a determinant of arterial stiffness in menopause: a mediation analysis
Objective: Associations of endogenous androgens in menopause with blood pressure (BP) and indices of arterial stiffness are reported, but directional relationships are not clear. Structural equation modeling is a contemporary statistical method, which allows assessment of such relationships and improves pathway understanding. Methods: We recruited 411 consecutive apparently healthy postmenopausal women who underwent noninvasive vascular evaluation. This included pulse wave analysis (aortic pressures and arterial wave reflections [augmentation index]), measurement of aortic stiffness by pulse wave velocity (PWV), stiffness...
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Menopausal symptom clusters and their correlates in women with and without a history of breast cancer: a pooled data analysis from the Women's Wellness Research Program
Objectives: This analysis examined climacteric symptoms clusters in women with and without breast cancer, and explored how sociodemographic, health, and modifiable lifestyle factors predicted symptom clusters. Methods: This pooled analysis of four Women's Wellness Research Program (WWRP) studies comprised individual-level data from 969 Australian women aged 40 to 63 years, 293 of whom had been previously treated for breast cancer and 678 without a breast cancer history. Climacteric symptoms, menopausal status, sociodemographic characteristics, and health and lifestyle factors were assessed. Principal component analysis wa...
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Exercise training ameliorates glucosamine-induced insulin resistance in ovariectomized rats
Conclusions: Exercise training can alleviate IR in OVX rats treated with GlcN. Islet hyperplasia was subsequently prevented. Preserving GLUT-4 expression may be one of the mechanisms by which exercise prevents IR. (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Malignancy risk of sonographically benign appearing purely solid adnexal masses in asymptomatic postmenopausal women
Conclusions: The risk of malignancy of benign appearing purely solid adnexal masses in asymptomatic postmenopausal women is low. Conservative management of these lesions might be an option. (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Association of sleep disturbance and sexual function in postmenopausal women
Objective: Sleep disturbance and sexual dysfunction are common in menopause; however, the nature of their association is unclear. The present study aimed to determine whether sleep characteristics were associated with sexual activity and sexual satisfaction. Methods: Sexual function in the last year and sleep characteristics (past 4 wk) were assessed by self-report at baseline for 93,668 women age 50 to 79 years enrolled in the Women's Health Initiative (WHI) Observational Study (OS). Insomnia was measured using the validated WHI Insomnia Rating Scale. Sleep-disordered breathing (SDB) risk was assessed using questions ada...
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Another link between exercise and relief from postmenopausal decline
No abstract available (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Editorials Source Type: research

Pelvic ultrasound: a powerful tool in managing the patient with an adnexal mass
No abstract available (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Editorials Source Type: research

Postmenopausal sleep disturbance and sexual dysfunction
No abstract available (Source: Menopause)
Source: Menopause - May 26, 2017 Category: OBGYN Tags: Editorials Source Type: research

Use of cardiovascular age for assessing risks and benefits of menopausal hormone therapy
Abstract: The Women's Health Initiative studies and others have suggested that menopausal hormone therapy may enhance the risk of new cardiovascular (CV) events in older women and diminish the development of coronary atherosclerosis in younger women. The underlying mechanisms to explain these findings are encapsulated in the term “Timing Hypothesis.” Extensive pathophysiologic studies have provided mechanistic evidence for the dichotomous effects of estrogen on coronary artery vasculature. Early in the atherosclerotic disease process, estrogen exerts protective effects on the endothelium and retards plaque form...
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Personal Perspective Source Type: research

Treating schizophrenia during menopause
Conclusions: Both HT and changes in antipsychotic management should be considered for women with schizophrenia at menopause. The question about differences in response between early- and late-onset women cannot yet be answered. (Source: Menopause)
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Review Article Source Type: research

Enhancing memory self-efficacy during menopause through a group memory strategies program
Conclusions: The use of group interventions to improve memory self-efficacy during menopause warrants continued evaluation. (Source: Menopause)
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Natural mineral-rich water ingestion by ovariectomized fructose-fed Sprague-Dawley rats: effects on sirtuin 1 and glucocorticoid signaling pathways
Objective: Prevention or induction of metabolic disorders and obesity depend on estrogen signaling and/or exogenous factors, such as mineral content in diet. The protective effects of a Portuguese natural mineral-rich water against the induction of metabolic syndrome in fructose-fed male Sprague-Dawley rats have been reported. The present study was designed to assess the impact of this mineral-rich water on fructose-fed estrogen-deficient female Sprague-Dawley rats. Methods: Ovariectomized rats had access to tap (TWO) or mineral-rich (MWO) waters, with and without 10% fructose (10-wk treatment). A sham-operated (tap water...
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

BH4 improves postprandial endothelial function after a high-fat meal in men and postmenopausal women
Objective: The timing and duration of menopause is important when evaluating the risk for cardiovascular disease in postmenopausal women, likely related in part to nitric oxide (NO) bioavailability. The flow-mediated dilation (FMD) test is a noninvasive assessment of NO bioavailability in humans, and tetrahydrobiopterin (BH4) is essential for NO synthesis. A high-fat meal (HFM) has been used to increase lipemia and reduce NO bioavailability. Thus, this study sought to determine if menopausal transition has any impact on the postprandial endothelial function response to a HFM, and evaluate the effect of BH4 on postprandial ...
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Psychometric properties of the Chinese version of the Menopause-Specific Quality-of-Life questionnaire
Conclusions: This study showed that Chinese version of MENQOL has good psychometric properties and would be suitable to measure the health-related quality-of-life of Chinese menopausal women except for item 21 (increased facial hair). (Source: Menopause)
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Prevalence and correlates of vaginal estrogenization in postmenopausal women in the United States
Objective: This work aims to establish current population-based vaginal estrogenization norms for postmenopausal US women. Methods: Using a US national probability sample of 868 postmenopausal women ages 57 to 85 years (mean age 67.6 ± 0.3 y, 21.6 ± 0.5 y since menopause), we calculated the epithelial maturation value (MV) generated from self-collected vaginal specimens and compared findings with historical clinical data. Linear and logistic regressions were used to describe the relationship between vaginal estrogenization and sociodemographic, physical, gynecologic, and sexual characteristics. Resu...
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Association between expression of inflammatory markers in normal breast tissue and mammographic density among premenopausal and postmenopausal women
Conclusions: Our results provide support for the hypothesized role of inflammatory markers in breast carcinogenesis through their effects on mammographic density. Inflammatory markers could be targeted in future breast cancer prevention interventions. (Source: Menopause)
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Comparative effectiveness of electro-acupuncture versus gabapentin for sleep disturbances in breast cancer survivors with hot flashes: a randomized trial
This study evaluated the effects of electro-acupuncture (EA) versus gabapentin (GP) for sleep disturbances among breast cancer survivors experiencing daily hot flashes. Methods: We analyzed data from a randomized controlled trial involving 58 breast cancer survivors experiencing bothersome hot flashes at least two times per day. Participants were randomly assigned to receive 8 weeks of EA or daily GP (total dose of 900 mg/d). The primary outcome was change in the total Pittsburgh Sleep Quality Index (PSQI) score between groups at week 8. Secondary outcomes include specific PSQI domains. Results: By the end of treatment...
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

TX-004HR vaginal estradiol has negligible to very low systemic absorption of estradiol
Conclusions: Vaginal TX-004HR resulted in negligible to very low systemic absorption of estradiol. No statistical differences in estradiol PK parameters were observed on day 14 with 4 and 10 μg, and only minor increases were observed with 25 μg (within the normal postmenopausal range). This PK substudy, in conjunction with the primary efficacy results, demonstrated that TX-004HR provided local benefits of estradiol with limited systemic exposure. (Source: Menopause)
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Skeletal muscle mass is associated with higher dietary protein intake and lower body fat in postmenopausal women: a cross-sectional study
Objective: We investigated the association between skeletal muscle mass and dietary protein intake, habitual physical activity, body composition, and metabolic variables. Methods: One hundred three healthy postmenopausal women from southern Brazil (age 55.2 ± 4.9 y, body mass index 27.2 ± 4.6 kg/m2) were enrolled. Bone mineral density, %body fat, %trunk fat mass, and appendicular lean mass were assessed by dual-energy x-ray absorptiometry, resting metabolic rate by indirect calorimetry, and habitual physical activity by pedometer. Skeletal muscle mass index (SMI) was expressed as appendicular lean ...
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Telomere length is longer in women with late maternal age
Conclusions: These findings show an association between longer leukocyte telomere length and a later maternal age at birth of last child, suggesting that extended maternal age at last childbirth may be a marker for longevity. (Source: Menopause)
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Impact of menopausal status on negative mood and depressive symptoms in a longitudinal sample spanning 20 years
This study examines negative mood and depressive occurrence in the menopausal stages to provide a better understanding of prevalence of mood disturbance during this period. Methods: This study was a longitudinal assessment of variables drawn from an epidemiological prospective study of women's healthy aging. Scores were analyzed using general linear mixed models to determine whether there were reductions in negative mood across the stages of the menopausal transition, including the substages of the early and late postmenopause, as defined by Stages of Reproductive Ageing Workshop+10 criteria. Negative mood scores, derived...
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Inaccurate self-report of height and its impact on misclassification of body mass index in postmenopausal women
Conclusions: Height misreporting was common in older women and significantly influenced BMI calculations and classification. Obtaining objective data is thus important for studies investigating obesity-disease associations in this population, especially in those with significant depressive symptoms. (Source: Menopause)
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Precision menopausal medicine
No abstract available (Source: Menopause)
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Editorials Source Type: research

Should postmenopausal women eat more protein? Or do the elite just exercise and eat better?
No abstract available (Source: Menopause)
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Editorials Source Type: research

Late maternal age at last childbirth and telomere homeostasis
No abstract available (Source: Menopause)
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Editorials Source Type: research

Beneficial effects of aging on mood in healthy postmenopausal women
No abstract available (Source: Menopause)
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Editorials Source Type: research

Self-reported height in postmenopausal women: precise is nice, and sometimes necessary
No abstract available (Source: Menopause)
Source: Menopause - April 27, 2017 Category: OBGYN Tags: Editorials Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

A sex-specific dose-response curve for testosterone: could excessive testosterone limit sexual interaction in women?
Abstract: Testosterone treatment increases sexual desire and well-being in women with hypoactive sexual desire disorder; however, many studies have shown only modest benefits limited to moderate doses. Unlike men, available data indicate women show a bell-shaped dose-response curve for testosterone, wherein a threshold dosage of testosterone leads to desirable sexual function effects, but exceeding this threshold results in a lack of further positive sexual effects or may have a negative impact. Emotional and physical side-effects of excess testosterone, including aggression and virilization, may counteract the modest bene...
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Personal Perspective Source Type: research

Is vulvovaginal atrophy due to a lack of both estrogens and androgens?
Conclusions: Practically all studies on the influence of steroid hormones in the vagina have focused on luminal epithelial cells. Since all estrogens and androgens in postmenopausal women are made intracellularly and derive from the conversion of circulating DHEA, it is of interest to observe from these preclinical data that DHEA exerts both estrogenic and androgenic activity in the three layers of the vagina, the stimulatory effect on nerve density being 100% androgenic. Taking vaginal weight as a global parameter, the stimulatory effect of DHEA in the rat vagina is about equally estrogenic and androgenic, thus illustrati...
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Review Article Source Type: research

Repurposing ospemifene for potentiating an antigen-specific immune response
Conclusions: Taken together, ospemifene's dose response and schedule-dependent immune modulating activity offers a method of tailoring and augmenting the efficacy of previously failed antigen-specific cancer vaccines for a wide range of malignancies. (Source: Menopause)
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Vertical sleeve gastrectomy improves indices of metabolic disease in rodent model of surgical menopause
Objective: Although women are the most common recipients of weight loss surgeries for the amelioration of the comorbidities of obesity, few studies have addressed the efficacy of these procedures with specific attention to reproductive stage. Here we ask in a rodent model of vertical sleeve gastrectomy (VSG) whether improvements to metabolic health are realized in women having received surgical menopause. Specifically we were interested in knowing whether rats made menopausal through surgical means would exhibit persistent hepatic steatosis as reported in previously pregnant, freely cycling female VSG rats or if it is reso...
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Clusters of midlife women by physical activity and their racial/ethnic differences
Objective: The purpose of this study was to identify clusters of midlife women by physical activity and to determine racial/ethnic differences in physical activities in each cluster. Methods: This was a secondary analysis of the data from 542 women (157 non-Hispanic [NH] Whites, 127 Hispanics, 135 NH African Americans, and 123 NH Asian) in a larger Internet study on midlife women's attitudes toward physical activity. The instruments included the Barriers to Health Activities Scale, the Physical Activity Assessment Inventory, the Questions on Attitudes toward Physical Activity, Subjective Norm, Perceived Behavioral Control...
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Original Articles Source Type: research

The REJOICE trial: a phase 3 randomized, controlled trial evaluating the safety and efficacy of a novel vaginal estradiol soft-gel capsule for symptomatic vulvar and vaginal atrophy
Objective: To evaluate the safety and efficacy of TX-004HR vaginal estradiol soft-gel capsules for moderate-to-severe dyspareunia associated with postmenopausal vulvar and vaginal atrophy. Methods: In this randomized, double-blind, placebo-controlled, phase 3 study, postmenopausal women with a self-identified most bothersome symptom of dyspareunia received 4, 10, or 25 μg TX-004HR or placebo for 12 weeks. Four co-primary efficacy endpoints were change from baseline to week 12 in percentages of superficial and parabasal cells, vaginal pH, and severity of dyspareunia. Secondary endpoints included severity of vaginal dr...
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Sex differences in episodic memory in early midlife: impact of reproductive aging
Objective: Few have characterized cognitive changes with age as a function of menopausal stage relative to men, or sex differences in components of memory in early midlife. The study aim was to investigate variation in memory function in early midlife as a function of sex, sex steroid hormones, and reproductive status. Methods: A total of 212 men and women aged 45 to 55 were selected for this cross-sectional study from a prenatal cohort of pregnancies whose mothers were originally recruited in 1959 to 1966. They underwent clinical and cognitive testing and hormonal assessments of menopause status. Multivariate general lin...
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Hypoactive sexual desire dysfunction in community-dwelling older women
Objective: To determine the prevalence of hypoactive sexual desire dysfunction (HSDD) and its associated factors in women aged 65 to 79 years. Methods: A questionnaire-based, cross-sectional study was conducted amongst community-dwelling older women. Participants were recruited between April and August 2014 from a national database based on electoral rolls. Sexual function and sexual distress were assessed by the Female Sexual Function Index and the Female Sexual Distress Scale-Revised, respectively. HSDD was defined as the presence of both low sexual desire and sexually related personal distress. Results: The mean &pl...
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Change in sexual functioning over the menopausal transition: results from the Study of Women's Health Across the Nation
Conclusions: Decline in sexual function became apparent 20 months before FMP and slowed 1 year after FMP through 5 years afterward. A decline in sexual function was observed immediately after hysterectomy and persisted for the 5 years of observation. (Source: Menopause)
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Age of menopause and fracture risk in postmenopausal women randomized to calcium + vitamin D, hormone therapy, or the combination: results from the Women's Health Initiative Clinical Trials
Objective: We previously reported that in the absence of hormone therapy (HT) or calcium/vitamin D (Ca/D) supplementation, earlier menopause age was associated with decreased bone mineral density and increased fracture risk in healthy postmenopausal women. Treatment with HT and Ca/D is protective against fractures after menopause. In this analysis, we asked if the age of menopause onset alters fracture risk in healthy postmenopausal women receiving HT, Ca/D, or a combination. Methods: Hazard ratios (HRs) for any fracture among 21,711 healthy postmenopausal women enrolled in the Women's Health Initiative Clinical Trial, wh...
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Original Articles Source Type: research

The cross-sectional association between vasomotor symptoms and hemostatic parameter levels in postmenopausal women
Conclusions: We found no convincing evidence that VMS presence or severity was associated with levels of hemostatic parameters among postmenopausal women. (Source: Menopause)
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Original Articles Source Type: research

Declining sexuality at midlife
No abstract available (Source: Menopause)
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Editorials Source Type: research

The Women's Health Initiative: evolving insights over 15 years
No abstract available (Source: Menopause)
Source: Menopause - March 30, 2017 Category: OBGYN Tags: Editorials Source Type: research

In Reply
No abstract available (Source: Menopause)
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

To the Editor
No abstract available (Source: Menopause)
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Letters to the Editor Source Type: research

Aging ovary and the role for advanced glycation end products
Conclusions: Further investigation of the role for the AGE-RAGE axis in the ovarian follicular environment is needed, and results could relate to assisted reproduction technology outcomes and new measures of ovarian reserve. (Source: Menopause)
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Review Articles Source Type: research

Moderate-vigorous recreational physical activity and breast cancer risk, stratified by menopause status: a systematic review and meta-analysis
Conclusions: Although risk estimates may be similar for premenopausal and postmenopausal breast cancer, subgroup effects may be menopause-dependent. (Source: Menopause)
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Review Articles Source Type: research

Is there a SERM in your menopause toolkit?
Abstract: Over the past 3 decades, compounds called selective estrogen receptor modulators (SERMs) have been developed that block the estrogen receptor in some tissues (estrogen receptor antagonists) or stimulate the estrogen receptor in other tissues (estrogen receptor agonists). This Practice Pearl focuses on SERMs that clinicians can use for menopausal patients. (Source: Menopause)
Source: Menopause - February 28, 2017 Category: OBGYN Tags: Clinical Corner: NAMS Practice Pearl Source Type: research